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1AWV
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CYPA COMPLEXED WITH HVGPIA
Descriptor: CYCLOPHILIN A, PEPTIDE FROM THE HIV-1 CAPSID PROTEIN
Authors:Vajdos, F.F.
Deposit date:1997-10-05
Release date:1998-03-18
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Protein Sci., 6, 1997
4J5C
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BU of 4j5c by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-[(2S)-4-(methylsulfanyl)-1-{(2R)-2-[2-(methylsulfanyl)phenyl]pyrrolidin-1-yl}-1-oxobutan-2-yl]urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
4JJM
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BU of 4jjm by Molmil
Structure of a cyclophilin from Citrus sinensis (CsCyp) in complex with cyclosporin A
Descriptor: Peptidyl-prolyl cis-trans isomerase, cyclosporin A
Authors:Campos, B.M, Ambrosio, A.L.B, Souza, T.A.C.B, Barbosa, J.A.R.G, Benedetti, C.E.
Deposit date:2013-03-08
Release date:2013-06-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:A redox 2-cys mechanism regulates the catalytic activity of divergent cyclophilins.
Plant Physiol., 162, 2013
1AWU
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CYPA COMPLEXED WITH HVGPIA (PSEUDO-SYMMETRIC MONOMER)
Descriptor: CYCLOPHILIN A, PEPTIDE FROM THE HIV-1 CAPSID PROTEIN
Authors:Vajdos, F.F.
Deposit date:1997-10-05
Release date:1998-03-18
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Protein Sci., 6, 1997
1NMK
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BU of 1nmk by Molmil
The Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
Descriptor: (13E,15E)-(3S,6S,9R,10R,11S,12S,18S,21S)-10,12-DIHYDROXY-3-(3-HYDROXYBEN-ZYL)-18-((E)-3-HYDROXY-1-METHYLPROPENYL)-6-ISOPROPYL-11-METHYL-9-(3-OXO-BUTYL)-19-OXA-1,4,7,25-TETRAAZA-BICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRAONE, Peptidyl-prolyl cis-trans isomerase A
Authors:Kallen, J, Sedrani, R, Wagner, J.
Deposit date:2003-01-10
Release date:2003-04-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data
J.Am.Chem.Soc., 125, 2003
4J5E
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BU of 4j5e by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-methoxyphenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
4J5D
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BU of 4j5d by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2-bromophenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
5NOZ
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BU of 5noz by Molmil
Structure of cyclophilin A in complex with 3,4-diaminobenzohydrazide
Descriptor: 3,4-bis(azanyl)benzohydrazide, Peptidyl-prolyl cis-trans isomerase A
Authors:Georgiou, C, Mcnae, I.W, Ioannidis, H, Julien, M, Walkinshaw, M.D.
Deposit date:2017-04-13
Release date:2017-07-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders.
J. Mol. Biol., 429, 2017
1MIK
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BU of 1mik by Molmil
THE ROLE OF WATER MOLECULES IN THE STRUCTURE-BASED DESIGN OF (5-HYDROXYNORVALINE)-2-CYCLOSPORIN: SYNTHESIS, BIOLOGICAL ACTIVITY, AND CRYSTALLOGRAPHIC ANALYSIS WITH CYCLOPHILIN A
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
Authors:Mikol, V.
Deposit date:1995-09-20
Release date:1996-03-08
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The Role of Water Molecules in the Structure-Based Design of (5-Hydroxynorvaline)-2-Cyclosporin: Synthesis, Biological Activity, and Crystallographic Analysis with Cyclophilin A.
J.Med.Chem., 38, 1995
1AWS
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BU of 1aws by Molmil
SECYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)
Descriptor: CYCLOPHILIN A, PEPTIDE FROM THE HIV-1 CAPSID PROTEIN
Authors:Vajdos, F.F.
Deposit date:1997-10-04
Release date:1998-03-18
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Protein Sci., 6, 1997
1AWQ
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BU of 1awq by Molmil
CYPA COMPLEXED WITH HAGPIA (PSEUDO-SYMMETRIC MONOMER)
Descriptor: CYCLOPHILIN A, PEPTIDE FROM THE HIV-1 CAPSID PROTEIN
Authors:Vajdos, F.F.
Deposit date:1997-10-04
Release date:1998-03-18
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Protein Sci., 6, 1997
1AK4
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BU of 1ak4 by Molmil
HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
Descriptor: CYCLOPHILIN A, HIV-1 CAPSID
Authors:Hill, C.P, Gamble, T.R, Vajdos, F.F, Worthylake, D.K, Sundquist, W.I.
Deposit date:1997-05-28
Release date:1997-10-15
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
Cell(Cambridge,Mass.), 87, 1996
1A58
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BU of 1a58 by Molmil
CYCLOPHILIN FROM BRUGIA MALAYI
Descriptor: CYCLOPHILIN
Authors:Taylor, P, Page, A.P, Kontopidis, G, Husi, H, Walkinshaw, M.D.
Deposit date:1998-02-20
Release date:1998-05-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi.
FEBS Lett., 425, 1998
5NOT
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BU of 5not by Molmil
Structure of cyclophilin A in complex with 4-chloropyrimidin-5-amine
Descriptor: 4-chloranylpyrimidin-5-amine, Peptidyl-prolyl cis-trans isomerase A
Authors:Georgiou, C, Mcnae, I.W, Ioannidis, H, Julien, M, Walkinshaw, M.D.
Deposit date:2017-04-13
Release date:2017-07-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders.
J. Mol. Biol., 429, 2017
5NOX
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BU of 5nox by Molmil
Structure of cyclophilin A in complex with 2-chloropyridin-3-amine
Descriptor: 2-chloranylpyridin-3-amine, Peptidyl-prolyl cis-trans isomerase A
Authors:Georgiou, C, Mcnae, I.W, Ioannidis, H, Julien, M, Walkinshaw, M.D.
Deposit date:2017-04-13
Release date:2017-07-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders.
J. Mol. Biol., 429, 2017
1A33
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BU of 1a33 by Molmil
PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI
Descriptor: PEPTIDYLPROLYL ISOMERASE
Authors:Mikol, V, Ma, D, Carlow, C.K.S.
Deposit date:1998-01-27
Release date:1998-07-29
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi.
Protein Sci., 7, 1998
5EX1
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BU of 5ex1 by Molmil
Crystal structure of cyclophilin AquaCyp300 from Hirschia baltica
Descriptor: MAGNESIUM ION, Peptidyl-prolyl cis-trans isomerase cyclophilin type
Authors:Jakob, R.P, Maier, T.
Deposit date:2015-11-23
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps.
Plos One, 11, 2016
1C5F
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BU of 1c5f by Molmil
CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A
Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 1
Authors:Ellis, P.J, Carlow, C.K.S, Ma, D, Kuhn, P.
Deposit date:1999-11-22
Release date:1999-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Crystal Structure of the Complex of Brugia Malayi Cyclophilin and Cyclosporin A.
Biochemistry, 39, 2000
5EX2
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BU of 5ex2 by Molmil
Crystal structure of cyclophilin AquaCyp293 from Hirschia baltica
Descriptor: CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Jakob, R.P, Maier, T.
Deposit date:2015-11-23
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.294 Å)
Cite:Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps.
Plos One, 11, 2016
5F66
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BU of 5f66 by Molmil
High-resolution isotropic multiconformer synchrotron model of CypA at 273 K
Descriptor: Peptidyl-prolyl cis-trans isomerase A
Authors:Fraser, J.S.
Deposit date:2015-12-05
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Measuring and modeling diffuse scattering in protein X-ray crystallography.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBT
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BU of 5cbt by Molmil
Human Cyclophilin D Complexed with Inhibitor
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, POTASSIUM ION, ...
Authors:Gibson, R.P, Shore, E, Kershaw, N, Awais, M, Javed, A, Latawiec, D, Pandalaneni, S, Wen, L, Berry, N, O'Neill, P, Sutton, R, Lian, L.Y.
Deposit date:2015-07-01
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Human Cyclophilin D Complexed with Inhibitor
To Be Published
4J59
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BU of 4j59 by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-{2-[(2R)-2-(naphthalen-1-yl)pyrrolidin-1-yl]-2-oxoethyl}urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Authors:Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016
5CBW
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BU of 5cbw by Molmil
Human Cyclophilin D Complexed with Inhibitor.
Descriptor: FORMIC ACID, POTASSIUM ION, Peptidyl-prolyl cis-trans isomerase F, ...
Authors:Gibson, R.P, Shore, E, Kershaw, N, Awais, M, Javed, A, Latawiec, D, Pandalaneni, S, Wen, L, Berry, N, O'Neill, P, Sutton, R, Lian, L.Y.
Deposit date:2015-07-01
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Cyclophilin D Complexed with Inhibitor.
To Be Published
4J5A
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BU of 4j5a by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-{2-[(2R)-2-(2,5-dimethoxyphenyl)pyrrolidin-1-yl]-2-oxoethyl}urea, DIMETHYL SULFOXIDE, Peptidyl-prolyl cis-trans isomerase F, ...
Authors:Gelin, M, Colliandre, L, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Rationnal Design of small-molecule inhibitors of human Cyclophilins and HCV replication.
to be published
4J58
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BU of 4j58 by Molmil
Human Cyclophilin D Complexed with an Inhibitor
Descriptor: 1-(4-aminobenzyl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, PHOSPHATE ION, Peptidyl-prolyl cis-trans isomerase F, ...
Authors:Colliandre, L, Gelin, M, Bessin, Y, Guichou, J.F.
Deposit date:2013-02-08
Release date:2014-02-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Nat Commun, 7, 2016

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