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5KLG
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BU of 5klg by Molmil
Structure of CavAb(W195Y) in complex with Br-dihydropyridine derivative UK-59811
Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ...
Authors:Tang, L, Gamal EL-Din, T.M, Swanson, T.M, Pryde, D.C, Scheuer, T, Zheng, N, Catterall, W.A.
Deposit date:2016-06-24
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs.
Nature, 537, 2016
5J9P
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BU of 5j9p by Molmil
KcsA in vitro
Descriptor: Fab, POTASSIUM ION, pH-gated potassium channel KcsA
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2016-04-10
Release date:2016-07-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression.
Biochemistry, 55, 2016
8J7H
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BU of 8j7h by Molmil
ion channel
Descriptor: ILE-ALA-ALA-ILE-HIS-ASN-ALA-ARG-ARG-LYS-LYS-ARG-GLU-ALA-ALA-ALA-ALA-HIS-LYS-ALA, ion channel
Authors:Chen, H.W, Jiang, D.H.
Deposit date:2023-04-27
Release date:2024-05-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:ion channel
To Be Published
8J7M
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BU of 8j7m by Molmil
ion channel
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL, ion channel,Voltage dependent ion channel,Green fluorescent protein (Fragment),Voltage dependent ion channel,Green fluorescent protein (Fragment),Voltage dependent ion channel,Green fluorescent protein (Fragment)
Authors:Chen, H.W, Chen, H.W.
Deposit date:2023-04-27
Release date:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:ion channel
To Be Published
8K3S
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BU of 8k3s by Molmil
Structure of PKD2-F604P complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ...
Authors:Chen, M.Y, Su, Q, Wang, Z.F, Yu, Y.
Deposit date:2023-07-16
Release date:2024-04-03
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.
Proc.Natl.Acad.Sci.USA, 121, 2024
5EBW
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BU of 5ebw by Molmil
KcsA with G77ester mutation
Descriptor: Antibody Fab Fragment Light Chain, DIACYL GLYCEROL, NONAN-1-OL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2015-10-19
Release date:2016-04-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.
Structure, 24, 2016
5E1A
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BU of 5e1a by Molmil
Structure of KcsA with L24C/R117C mutations
Descriptor: POTASSIUM ION, antibody Fab fragment heavy chain, antibody Fab fragment light chain, ...
Authors:Upadhyay, V, Kim, D.M, Nimigean, C.M.
Deposit date:2015-09-29
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.
J.Gen.Physiol., 148, 2016
5EC1
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BU of 5ec1 by Molmil
KcsA with V76ester mutation
Descriptor: Antibody Fab Fragment Light Chain, DIACYL GLYCEROL, NONAN-1-OL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2015-10-20
Release date:2016-04-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.
Structure, 24, 2016
5EBL
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BU of 5ebl by Molmil
KcsA T75G in the Conductive State
Descriptor: Antibody Fab Fragment Light Chain, DIACYL GLYCEROL, NONAN-1-OL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2015-10-19
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.
Structure, 24, 2016
5EC2
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BU of 5ec2 by Molmil
KcsA with V76ester+G77dA mutations
Descriptor: Antibody Fab Fragment Light Chain, DIACYL GLYCEROL, NONAN-1-OL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2015-10-20
Release date:2016-04-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.
Structure, 24, 2016
5EBM
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BU of 5ebm by Molmil
KcsA T75G mutant in the nonconductive state
Descriptor: Antibody Fab Fragment Light Chain, DIACYL GLYCEROL, NONAN-1-OL, ...
Authors:Matulef, K, Valiyaveetil, F.I.
Deposit date:2015-10-19
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation.
Structure, 24, 2016
5EK0
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BU of 5ek0 by Molmil
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha
Authors:Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J.
Deposit date:2015-11-03
Release date:2015-12-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015
5BZB
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BU of 5bzb by Molmil
NavMs voltage-gated sodium channel pore and C-terminal domain
Descriptor: DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ...
Authors:Naylor, C.E, Bagneris, C, Wallace, B.A.
Deposit date:2015-06-11
Release date:2016-02-24
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis of ion permeability in a voltage-gated sodium channel.
Embo J., 35, 2016
6P6W
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BU of 6p6w by Molmil
Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state
Descriptor: Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
6PKW
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BU of 6pkw by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
2H8P
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BU of 2h8p by Molmil
Structure of a K channel with an amide to ester substitution in the selectivity filter
Descriptor: (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE, FAB heavy chain, FAB light chain, ...
Authors:Valiyaveetil, F.I, MacKinnon, R, Muir, T.W.
Deposit date:2006-06-07
Release date:2006-09-12
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.
J.Am.Chem.Soc., 128, 2006
6PA0
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BU of 6pa0 by Molmil
Structure of the G77A mutant in Sodium Chloride
Descriptor: Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ...
Authors:Cuello, L.G, Guan, L.
Deposit date:2019-06-11
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
6PKV
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BU of 6pkv by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6P6Y
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BU of 6p6y by Molmil
Crystal structure of voltage-gated sodium channel NavAb V100C/Q150C disulfide crosslinked mutant in the activated state
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
6PIS
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BU of 6pis by Molmil
Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM ION, ...
Authors:Brohawn, S.G.
Deposit date:2019-06-27
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier.
Elife, 8, 2019
6P6X
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BU of 6p6x by Molmil
Crystal structure of voltage-gated sodium channel NavAb G94C/Q150C mutant in the activated state
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein
Authors:Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A.
Deposit date:2019-06-04
Release date:2019-08-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Cell, 178, 2019
2IH3
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BU of 2ih3 by Molmil
Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB Heavy Chain, FAB Light Chain, ...
Authors:Valiyaveetil, F.I, Leonetti, M, Muir, T.W, MacKinnon, R.
Deposit date:2006-09-25
Release date:2006-11-21
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Ion Selectivity in a Semisynthetic K+ Channel Locked in the Conductive Conformation.
Science, 314, 2006
2ITD
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BU of 2itd by Molmil
Potassium Channel KcsA-Fab complex in Barium Chloride
Descriptor: BARIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ...
Authors:Lockless, S.W, Zhou, M, MacKinnon, R.
Deposit date:2006-10-19
Release date:2007-05-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
2ITC
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BU of 2itc by Molmil
Potassium Channel KcsA-Fab complex in Sodium Chloride
Descriptor: Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, SODIUM ION, ...
Authors:Lockless, S.W, Zhou, M, MacKinnon, R.
Deposit date:2006-10-19
Release date:2007-05-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel.
Plos Biol., 5, 2007
2HJF
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BU of 2hjf by Molmil
Potassium channel kcsa-fab complex with tetrabutylammonium (TBA)
Descriptor: Antibody fragment Heavy chain, Antibody fragment Light chain, POTASSIUM ION, ...
Authors:Faraldo-Gomez, J.D, Kutluay, E, Jogini, V, Zhao, Y, Heginbotham, L, Roux, B.
Deposit date:2006-06-30
Release date:2006-12-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mechanism of Intracellular Block of the KcsA K(+) Channel by Tetrabutylammonium: Insights from X-ray Crystallography, Electrophysiology and Replica-exchange Molecular Dynamics Simulations.
J.Mol.Biol., 365, 2007

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