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4TWJ
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BU of 4twj by Molmil
The structure of Sir2Af2 bound to a myristoylated histone peptide
Descriptor: ACETATE ION, GLYCEROL, Histone H4 peptide, ...
Authors:Ringel, A.E, Roman, C, Wolberger, C.
Deposit date:2014-06-30
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.
Protein Sci., 23, 2014
3GLS
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BU of 3gls by Molmil
Crystal Structure of Human SIRT3
Descriptor: NAD-dependent deacetylase sirtuin-3, mitochondrial, SULFATE ION, ...
Authors:Jin, L, Wei, W, Jiang, Y, Peng, H, Cai, J, Mao, C, Dai, H, Bemis, J.E, Jirousek, M.R, Milne, J.C, Westphal, C.H, Perni, R.B.
Deposit date:2009-03-12
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes.
J.Biol.Chem., 284, 2009
3JWP
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BU of 3jwp by Molmil
Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, TRIETHYLENE GLYCOL, Transcriptional regulatory protein sir2 homologue, ...
Authors:Wernimont, A.K, Hutchinson, A, Lin, Y.H, MacKenzie, F, Senisterra, G, Allali-Hassanali, A, Vedadi, M, Ravichandran, M, Cossar, D, Kozieradzki, I, Zhao, Y, Schapira, M, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Qiu, W, Brand, V, Structural Genomics Consortium (SGC)
Deposit date:2009-09-18
Release date:2009-10-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP
TO BE PUBLISHED
3K35
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BU of 3k35 by Molmil
Crystal Structure of Human SIRT6
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent deacetylase sirtuin-6, SULFATE ION, ...
Authors:Pan, P.W, Dong, A, Qiu, W, Loppnau, P, Wang, J, Ravichandran, M, Bochkarev, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Min, J, Edwards, A.M, Structural Genomics Consortium (SGC)
Deposit date:2009-10-01
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and biochemical functions of SIRT6.
J.Biol.Chem., 286, 2011
3JR3
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BU of 3jr3 by Molmil
Sir2 bound to acetylated peptide
Descriptor: Acetylated Peptide, NAD-dependent deacetylase, ZINC ION
Authors:Hawse, W.F, Wolberger, C.
Deposit date:2009-09-08
Release date:2009-09-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based mechanism of ADP-ribosylation by sirtuins.
J.Biol.Chem., 284, 2009
6ISO
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BU of 6iso by Molmil
Human SIRT3 Recognizing H3K4cr
Descriptor: (2E)-BUT-2-ENAL, ARG-THR-LYS-GLN-THR-ALA-ARG, GLYCEROL, ...
Authors:Wang, Y, Hao, Q.
Deposit date:2018-11-17
Release date:2019-01-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
Elife, 3, 2014
6L65
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BU of 6l65 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide
Descriptor: MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ...
Authors:Chen, L.F.
Deposit date:2019-10-28
Release date:2020-11-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6LJM
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BU of 6ljm by Molmil
Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P13
Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-SER-LEU-GLY-SLL, NAD-dependent protein deacylase sirtuin-5, ...
Authors:Chen, Q, Yu, Y.
Deposit date:2019-12-17
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
Eur.J.Med.Chem., 192, 2020
6L66
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BU of 6l66 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule
Descriptor: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
Authors:Chen, L.F.
Deposit date:2019-10-28
Release date:2020-11-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.169 Å)
Cite:Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6LJN
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BU of 6ljn by Molmil
Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P15
Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, ACE-HIS-PHE-SER-SLL, NAD-dependent protein deacylase sirtuin-5, ...
Authors:Chen, Q, Yu, Y.
Deposit date:2019-12-17
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
Eur.J.Med.Chem., 192, 2020
6LJK
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BU of 6ljk by Molmil
Crystal structure of human Sirt5 in complex with an internally quenched fluorescent substrate GluIQF
Descriptor: BE2-SER-ALA-ILE-LYS-SER-NIY-GLY-SET, GLUTARIC ACID, NAD-dependent protein deacylase sirtuin-5, ...
Authors:Chen, Q, Yu, Y.
Deposit date:2019-12-17
Release date:2020-12-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.394 Å)
Cite:Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery.
Eur.J.Med.Chem., 192, 2020
6L72
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BU of 6l72 by Molmil
Sirtuin 2 demyristoylation native final product
Descriptor: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate
Authors:Chen, L.F.
Deposit date:2019-10-30
Release date:2021-03-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L71
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BU of 6l71 by Molmil
Sirtuin 2 demyristoylation native intermediate I & II mixture
Descriptor: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
Authors:Chen, L.F.
Deposit date:2019-10-30
Release date:2021-03-31
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.109 Å)
Cite:Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
5BWO
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BU of 5bwo by Molmil
Crystal Structure of Human SIRT3 in Complex with a Palmitoyl H3K9 Peptide
Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, PALMITIC ACID, ...
Authors:Gai, W, Jiang, H, Liu, D.
Deposit date:2015-06-08
Release date:2016-07-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.376 Å)
Cite:Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine.
Febs Lett., 590, 2016
5BWL
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BU of 5bwl by Molmil
Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide
Descriptor: 7-AMINO-4-METHYL-CHROMEN-2-ONE, Coumarin-labelled succinyl peptide, NAD-dependent protein deacylase sirtuin-5, ...
Authors:Gai, W, Jiang, H, Liu, D.
Deposit date:2015-06-08
Release date:2016-07-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.548 Å)
Cite:Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide
To be published
1M2K
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BU of 1m2k by Molmil
Sir2 homologue F159A mutant-ADP ribose complex
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION
Authors:Chang, J, Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
5D7P
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BU of 5d7p by Molmil
Crystal structure of human Sirt2 in complex with ADPR and EX-243
Descriptor: (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-2, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-08-14
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
Acta Crystallogr.,Sect.F, 71, 2015
5DY4
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BU of 5dy4 by Molmil
Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+
Descriptor: N-{5-[(7-bromonaphthalen-1-yl)methyl]-1,3-thiazol-2-yl}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide, NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-09-24
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.
J.Med.Chem., 59, 2016
5DY5
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BU of 5dy5 by Molmil
Crystal structure of human Sirt2 in complex with a SirReal probe fragment
Descriptor: (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-09-24
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Development of an Affinity Probe for Sirtuin 2.
Angew.Chem.Int.Ed.Engl., 55, 2016
5D7Q
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BU of 5d7q by Molmil
Crystal structure of human Sirt2 in complex with ADPR and CHIC35
Descriptor: (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-08-14
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
Acta Crystallogr.,Sect.F, 71, 2015
5D7O
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BU of 5d7o by Molmil
Crystal structure of Sirt2-ADPR at an improved resolution
Descriptor: NAD-dependent protein deacetylase sirtuin-2, TRIETHYLENE GLYCOL, ZINC ION, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-08-14
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
Acta Crystallogr.,Sect.F, 71, 2015
5D7N
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BU of 5d7n by Molmil
Crystal structure of human Sirt3 at an improved resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ...
Authors:Rumpf, T, Gerhardt, S, Einsle, O, Jung, M.
Deposit date:2015-08-14
Release date:2015-12-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.
Acta Crystallogr.,Sect.F, 71, 2015
1M2G
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BU of 1m2g by Molmil
Sir2 homologue-ADP ribose complex
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Silent Information Regulator 2, ZINC ION
Authors:Chang, J, Cho, Y.
Deposit date:2002-06-24
Release date:2003-04-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for the NAD-dependent deacetylase mechanism of Sir2
J.BIOL.CHEM., 277, 2002
1Q1A
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BU of 1q1a by Molmil
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
Descriptor: 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, HST2 protein, Histone H4, ...
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-Acetyl ADP ribose and histone peptide.
Structure, 11, 2003
1Q17
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BU of 1q17 by Molmil
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, HST2 protein, ...
Authors:Zhao, K, Chai, X, Marmorstein, R.
Deposit date:2003-07-18
Release date:2003-11-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2'-O-Acetyl ADP Ribose and Histone Peptide.
Structure, 11, 2003

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