5DY5

Crystal structure of human Sirt2 in complex with a SirReal probe fragment

Summary for 5DY5

Entry DOI	10.2210/pdb5dy5/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-2, ZINC ION, N-(5-{3-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]benzyl}-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide, ... (7 entities in total)
Functional Keywords	hydrolase, hydrolase inhibitor complex
Biological source	Homo sapiens (Human)
Cellular location	Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
Total number of polymer chains	1
Total formula weight	35430.32
Authors	Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M. (deposition date: 2015-09-24, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Schiedel, M.,Rumpf, T.,Karaman, B.,Lehotzky, A.,Gerhardt, S.,Ovadi, J.,Sippl, W.,Einsle, O.,Jung, M. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew.Chem.Int.Ed.Engl., 55:2252-2256, 2016 Cited by PubMed: 26748890 DOI: 10.1002/anie.201509843 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation