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5Y53
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BU of 5y53 by Molmil
Crystal structure of AL2 PAL domain in complex with AtBMI1b binding site
Descriptor: AtBMI1b binding site, PHD finger protein ALFIN-LIKE 2
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-08-07
Release date:2018-08-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5Y21
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BU of 5y21 by Molmil
Crystal structure of AL2 PAL domain in complex with AtRing1a proximal site
Descriptor: AtRing1a proximal binding site peptide, PHD finger protein ALFIN-LIKE 2
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-07-22
Release date:2018-07-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5Y20
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BU of 5y20 by Molmil
Crystal structure of AL1 PHD finger bound to H3K4me3
Descriptor: PEPTIDE FROM HISTONE H3, PHD finger protein ALFIN-LIKE 1, ZINC ION
Authors:Zhao, S, Zhang, B, Li, H.
Deposit date:2017-07-22
Release date:2018-01-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Systematic Profiling of Histone Readers in Arabidopsis thaliana.
Cell Rep, 22, 2018
5XVW
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BU of 5xvw by Molmil
Crystal structure of AL2 PAL domain in complex with AtRing1a distal site
Descriptor: AtRing1a distal binding site, PHD finger protein ALFIN-LIKE 2
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5XVL
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BU of 5xvl by Molmil
Crystal structure of AL2 PAL domain
Descriptor: PHD finger protein ALFIN-LIKE 2, SULFATE ION
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.629 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5XVJ
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BU of 5xvj by Molmil
Crystal structure of AL7 PAL domain
Descriptor: PHD finger protein ALFIN-LIKE 7, SULFATE ION
Authors:Peng, L, Wang, L.L, Huang, Y.
Deposit date:2017-06-28
Release date:2018-07-04
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
J. Mol. Biol., 430, 2018
5XMY
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BU of 5xmy by Molmil
Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser
Descriptor: Histone peptide H3(1-15)K4me3Q5ser, Transcription initiation factor TFIID subunit 3, ZINC ION
Authors:Zhao, S, Zhang, B, Li, H.
Deposit date:2017-05-16
Release date:2018-11-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Crystal structure of TAF3 PHD finger bound to H3K4me3Q5ser
to be published
5WXH
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BU of 5wxh by Molmil
Crystal structure of TAF3 PHD finger bound to H3K4me3
Descriptor: Histone H3K4me3, Transcription initiation factor TFIID subunit 3, ZINC ION
Authors:Zhao, S, Huang, J, Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.297 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WXG
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BU of 5wxg by Molmil
Structure of TAF PHD finger domain binds to H3(1-15)K4ac
Descriptor: Histone H3K4ac, MAGNESIUM ION, Transcription initiation factor TFIID subunit 3, ...
Authors:Zhao, S, Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WMF
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BU of 5wmf by Molmil
Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1
Descriptor: Epstein-Barr nuclear antigen 1
Authors:Messick, T.E.
Deposit date:2017-07-28
Release date:2017-08-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.
J. Virol., 91, 2017
5WLF
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BU of 5wlf by Molmil
Crystal structure of the apo PPS PHD finger
Descriptor: GLYCEROL, Protein partner of snf, isoform A, ...
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2017-07-26
Release date:2017-10-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5WLE
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BU of 5wle by Molmil
Crystal structure of the PPS PHD finger in complex with H3K4me3
Descriptor: H3K4me3 Peptide, Protein partner of snf, isoform A, ...
Authors:Klein, B.J, Kutateladze, T.G.
Deposit date:2017-07-26
Release date:2017-10-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
Structure, 25, 2017
5WAK
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BU of 5wak by Molmil
Crystal Structure of a Suz12-Rbbp4 Binary Complex
Descriptor: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION
Authors:Chen, S, Jiao, L, Liu, X.
Deposit date:2017-06-26
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
Mol. Cell, 69, 2018
5WAI
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BU of 5wai by Molmil
Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex
Descriptor: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ...
Authors:Chen, S, Jiao, L, Liu, X.
Deposit date:2017-06-26
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.
Mol. Cell, 69, 2018
5VAR
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BU of 5var by Molmil
Crystal structure of KDM4A tandem TUDOR domain in complex with a tri-methyl lysine competitive inhibitor
Descriptor: (1R,2S,3R,4S)-3-[(dimethylamino)methyl]-1-phenylbicyclo[2.2.1]heptan-2-ol, Lysine-specific demethylase 4A
Authors:Judge, R.A, Upadhyay, A.K.
Deposit date:2017-03-27
Release date:2018-03-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.
Bioorg. Med. Chem. Lett., 28, 2018
5V9T
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BU of 5v9t by Molmil
Crystal structure of selective pyrrolidine amide KDM5a inhibitor N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide (compound 48)
Descriptor: Lysine-specific demethylase 5A, N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide, NICKEL (II) ION, ...
Authors:Kiefer, J.R, Liang, J, Vinogradova, M.
Deposit date:2017-03-23
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5V9P
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BU of 5v9p by Molmil
Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A
Descriptor: Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ...
Authors:Kiefer, J.R, Liang, J, Vinogradova, M.
Deposit date:2017-03-23
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5TDW
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BU of 5tdw by Molmil
Set3 PHD finger in complex with histone H3K4me3
Descriptor: SET domain-containing protein 3, SODIUM ION, ZINC ION, ...
Authors:Andrews, F.H, Ali, M, Kutateladze, T.G.
Deposit date:2016-09-19
Release date:2016-10-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
5SVX
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BU of 5svx by Molmil
MORC3 CW in complex with histone H3K4me3
Descriptor: H3K4me3, MORC family CW-type zinc finger protein 3, ZINC ION
Authors:Tong, Q, Andrews, F.H, Kutateladze, T.G.
Deposit date:2016-08-08
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
Cell Rep, 16, 2016
5MTO
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BU of 5mto by Molmil
N-terminal domain of the human tumor suppressor ING5 C19S mutant
Descriptor: Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G, Buitrago, J.A.R, Roversi, P, Rojas, A.L, Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
5ME8
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BU of 5me8 by Molmil
N-terminal domain of the human tumor suppressor ING5
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Inhibitor of growth protein 5
Authors:Roversi, P, Blanco, F.J, Rojas, A.L, Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
5LHI
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BU of 5lhi by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor N-[3-(ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Cecatiello, V, Pasqualato, S.
Deposit date:2016-07-12
Release date:2017-02-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHH
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BU of 5lhh by Molmil
Structure of the KDM1A/CoREST complex with the inhibitor 4-ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide
Descriptor: 4-ethyl-~{N}-[3-(methoxymethyl)-2-[[4-[[(3~{R})-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Cecatiello, V, Pasqualato, S.
Deposit date:2016-07-11
Release date:2017-02-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5LHG
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Structure of the KDM1A/CoREST complex with the inhibitor 4-methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide
Descriptor: 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl)oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Cecatiello, V, Pasqualato, S.
Deposit date:2016-07-11
Release date:2017-02-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60, 2017
5L3D
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BU of 5l3d by Molmil
Human LSD1/CoREST: LSD1 Y761H mutation
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, REST corepressor 1
Authors:Pilotto, S, Speranzini, V, Marabelli, C, Mattevi, A.
Deposit date:2016-04-06
Release date:2016-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Hum.Mol.Genet., 25, 2016

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PDB entries from 2024-09-18

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