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6EGR
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BU of 6egr by Molmil
Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement
Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Revtovich, S.V, Demitri, N, Raboni, S, Nikulin, A.D, Morozova, E.A, Demidkina, T.V, Storici, P, Mozzarelli, A.
Deposit date:2017-09-12
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
4U2H
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BU of 4u2h by Molmil
The crystal structure of apo CalE6, a methionine gamma lyase from Micromonospora echinospora
Descriptor: CalE6, SULFATE ION
Authors:Song, H.G, Xu, R.
Deposit date:2014-07-17
Release date:2015-01-07
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and Characterization of a Methionine gamma-Lyase in the Calicheamicin Biosynthetic Cluster of Micromonospora echinospora
Chembiochem, 16, 2015
3VK2
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BU of 3vk2 by Molmil
Crystal Structure of L-Methionine gamma-Lyase from Pseudomonas putida C116H Mutant.
Descriptor: Methionine gamma-lyase, SULFATE ION
Authors:Fukumoto, M, Kudou, D, Murano, S, Shiba, T, Sato, D, Tamura, T, Harada, S, Inagaki, K.
Deposit date:2011-11-07
Release date:2012-09-19
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of amino acid residues in the active site of L-methionine gamma-lyase from Pseudomonas putida.
Biosci.Biotechnol.Biochem., 76, 2012
1IBJ
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BU of 1ibj by Molmil
Crystal structure of cystathionine beta-lyase from Arabidopsis thaliana
Descriptor: CARBONATE ION, CYSTATHIONINE BETA-LYASE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Breitinger, U, Clausen, T, Messerschmidt, A.
Deposit date:2001-03-28
Release date:2001-04-04
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The three-dimensional structure of cystathionine beta-lyase from Arabidopsis and its substrate specificity
Plant Physiol., 126, 2001
1N8P
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BU of 1n8p by Molmil
Crystal Structure of cystathionine gamma-lyase from yeast
Descriptor: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
Authors:Messerschmidt, A, Worbs, M, Steegborn, C, Wahl, M.C, Huber, R, Clausen, T.
Deposit date:2002-11-21
Release date:2002-12-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Determinants of Enzymatic Specificity in the Cys-Met-Metabolism PLP-Dependent Enzymes Family: Crystal Structure of Cystathionine gamma-lyase from Yeast and Intrafamiliar Structural Comparison
BIOL.CHEM., 384, 2003
4MKJ
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BU of 4mkj by Molmil
Crystal structure of L-methionine gamma-lyase from Citrobacter freundii modified by allicine
Descriptor: Methionine gamma-lyase, PENTAETHYLENE GLYCOL, SODIUM ION, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Zakomirdina, L.N, Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4MKK
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BU of 4mkk by Molmil
Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii modified by allicine
Descriptor: CHLORIDE ION, Methionine gamma-lyase, POTASSIUM ION, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Zakomirdina, L.N, Demidkina, T.V.
Deposit date:2013-09-05
Release date:2014-11-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme.
Acta Crystallogr.,Sect.D, 70, 2014
4OMA
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BU of 4oma by Molmil
The crystal structure of methionine gamma-lyase from Citrobacter freundii in complex with L-cycloserine pyridoxal-5'-phosphate
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2014-01-27
Release date:2014-11-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine gamma-Lyase from Citrobacter freundii with Inhibitors.
J.Biol.Chem., 290, 2015
3NDN
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BU of 3ndn by Molmil
Crystal structure of O-succinylhomoserine sulfhydrylase from Mycobacterium tuberculosis covalently bound to pyridoxal-5-phosphate
Descriptor: O-succinylhomoserine sulfhydrylase
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2010-06-07
Release date:2010-06-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
1I43
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BU of 1i43 by Molmil
CYSTATHIONINE GAMMA-SYNTHASE IN COMPLEX WITH THE INHIBITOR PPCA
Descriptor: 3-(PHOSPHONOMETHYL)PYRIDINE-2-CARBOXYLIC ACID, CYSTATHIONINE GAMMA-SYNTHASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Steegborn, C, Laber, B, Messerschmidt, A, Huber, R, Clausen, T.
Deposit date:2001-02-19
Release date:2001-09-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
J.Mol.Biol., 311, 2001
1I48
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BU of 1i48 by Molmil
CYSTATHIONINE GAMMA-SYNTHASE IN COMPLEX WITH THE INHIBITOR CTCPO
Descriptor: CARBOXYMETHYLTHIO-3-(3-CHLOROPHENYL)-1,2,4-OXADIAZOL, CYSTATHIONINE GAMMA-SYNTHASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Steegborn, C, Laber, B, Messerschmidt, A, Huber, R, Clausen, T.
Deposit date:2001-02-20
Release date:2001-09-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
J.Mol.Biol., 311, 2001
1I41
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BU of 1i41 by Molmil
CYSTATHIONINE GAMMA-SYNTHASE IN COMPLEX WITH THE INHIBITOR APPA
Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-IMINO]-5-PHOSPHONO-PENT-3-ENOIC ACID, CYSTATHIONINE GAMMA-SYNTHASE
Authors:Steegborn, C, Laber, B, Messerschmidt, A, Huber, R, Clausen, T.
Deposit date:2001-02-19
Release date:2001-09-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
J.Mol.Biol., 311, 2001
1PFF
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BU of 1pff by Molmil
Crystal Structure of Homocysteine alpha-, gamma-lyase at 1.8 Angstroms
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, methionine gamma-lyase
Authors:Allen, T.W, Sridhar, V, Prasad, S.G, Han, Q, Xu, M, Tan, Y, Hoffman, R.M, Ramaswamy, S.
Deposit date:2003-05-26
Release date:2004-08-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:

1PG8
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BU of 1pg8 by Molmil
Crystal Structure of L-methionine alpha-, gamma-lyase
Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Allen, T.W, Sridhar, V, Prasad, G.S, Han, Q, Xu, M, Tan, Y, Hoffman, R.M, Ramaswamy, S.
Deposit date:2003-05-28
Release date:2004-06-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:
To Be Published
3QI6
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BU of 3qi6 by Molmil
Crystal Structure of Cystathionine gamma-synthase MetB (Cgs) from Mycobacterium ulcerans Agy99
Descriptor: 1,2-ETHANEDIOL, Cystathionine gamma-synthase MetB (Cgs), GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-01-26
Release date:2011-03-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structure of the cystathionine [gamma]-synthase MetB from Mycobacterium ulcerans
Acta Crystallogr.,Sect.F, 67, 2011
3QHX
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BU of 3qhx by Molmil
Crystal Structure of Cystathionine gamma-synthase MetB (Cgs) from Mycobacterium ulcerans Agy99 bound to HEPES
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cystathionine gamma-synthase MetB (Cgs), GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-01-26
Release date:2011-03-02
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of the cystathionine [gamma]-synthase MetB from Mycobacterium ulcerans
Acta Crystallogr.,Sect.F, 67, 2011
4OC9
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BU of 4oc9 by Molmil
2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205
Descriptor: GLYCEROL, IMIDAZOLE, PHOSPHATE ION, ...
Authors:Halavaty, A.S, Brunzelle, J.S, Wawrzak, Z, Onopriyenko, O, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-01-08
Release date:2014-03-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:2.35 Angstrom resolution crystal structure of putative O-acetylhomoserine (thiol)-lyase (metY) from Campylobacter jejuni subsp. jejuni NCTC 11168 with N'-Pyridoxyl-Lysine-5'-Monophosphate at position 205
To be Published
1QGN
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BU of 1qgn by Molmil
CYSTATHIONINE GAMMA-SYNTHASE FROM NICOTIANA TABACUM
Descriptor: PROTEIN (CYSTATHIONINE GAMMA-SYNTHASE), PYRIDOXAL-5'-PHOSPHATE
Authors:Steegborn, C, Messerschmidt, A, Laber, B, Streber, W, Huber, R, Clausen, T.
Deposit date:1999-05-02
Release date:1999-08-25
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
J.Mol.Biol., 290, 1999
3RI6
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BU of 3ri6 by Molmil
A Novel Mechanism of Sulfur Transfer Catalyzed by O-Acetylhomoserine Sulfhydrylase in Methionine Biosynthetic Pathway of Wolinella succinogenes
Descriptor: O-ACETYLHOMOSERINE SULFHYDRYLASE
Authors:Tran, T.H, Krishnamoorthy, K, Begley, T.P, Ealick, S.E.
Deposit date:2011-04-13
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.
Acta Crystallogr.,Sect.D, 67, 2011
5X2W
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BU of 5x2w by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase wild type with L-methionine intermediates
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid, L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2Z
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BU of 5x2z by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase C116H mutant with L-methionine intermediates
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid, L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2V
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BU of 5x2v by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase wild type without sulfate ion
Descriptor: L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X2Y
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BU of 5x2y by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase C116H mutant without sulfate ion
Descriptor: L-methionine gamma-lyase
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
5X30
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BU of 5x30 by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase C116H mutant with L-homocysteine intermediates.
Descriptor: (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, (2~{S})-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]-4-sulfanyl-butanoic acid, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, ...
Authors:Shiba, T, Sato, D, Harada, S.
Deposit date:2017-02-02
Release date:2017-04-12
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci., 26, 2017
7F1U
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BU of 7f1u by Molmil
Crystal structure of Pseudomonas putida methionine gamma-lyase Q349S mutant with L-methionine intermediates
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]-4-(methylsulfanyl)but-2-enoic acid, L-methionine gamma-lyase, METHIONINE
Authors:Okawa, A, Handa, H, Yasuda, E, Murota, M, Kudo, D, Tamura, T, Shiba, T, Inagaki, K.
Deposit date:2021-06-09
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterization and application of l-methionine gamma-lyase Q349S mutant enzyme with an enhanced activity toward l-homocysteine.
J.Biosci.Bioeng., 133, 2022

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