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8OO6
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BU of 8oo6 by Molmil
Pol I bound to extended and displaced DNA section - closed conformation
Descriptor: DNA polymerase I, Displaced primer, Extending Primer, ...
Authors:Botto, M, Borsellini, A, Lamers, M.H.
Deposit date:2023-04-04
Release date:2023-08-09
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:A four-point molecular handover during Okazaki maturation.
Nat.Struct.Mol.Biol., 30, 2023
8OOY
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BU of 8ooy by Molmil
Pol I bound to extended and displaced DNA section - open conformation
Descriptor: DNA polymerase I, Displacing Primer, Extending Primer, ...
Authors:Botto, M, Borsellini, A, Lamers, M.H.
Deposit date:2023-04-06
Release date:2023-08-09
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:A four-point molecular handover during Okazaki maturation.
Nat.Struct.Mol.Biol., 30, 2023
5O7T
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BU of 5o7t by Molmil
Crystal structure of KlenTaq mutant M747K in a closed ternary complex with a dG:dCTP base pair
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase I, thermostable, ...
Authors:Betz, K, Diederichs, K, Marx, A.
Deposit date:2017-06-09
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
Chem. Commun. (Camb.), 53, 2017
6Q4U
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BU of 6q4u by Molmil
KlenTaq DNA pol in a closed ternary complex with 7-deaza-7-(2-(2-hydroxyethoxy)-N-(prop-2-yn-1-yl)acetamide)-2-dATP
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*CP*TP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*(DOC))-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2018-12-06
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.
Angew.Chem.Int.Ed.Engl., 58, 2019
3HP6
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BU of 3hp6 by Molmil
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus F710Y mutant bound to G:T mismatch
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*CP*CP*GP*TP*GP*AP*TP*CP*G)-3', 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DDG))-3', ...
Authors:Wu, E.Y, Beese, L.S.
Deposit date:2009-06-03
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
3HPO
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BU of 3hpo by Molmil
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus Y714S mutant bound to G:T mismatch
Descriptor: 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3', 5'-D(P*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3', DNA polymerase I, ...
Authors:Wu, E.Y, Beese, L.S.
Deposit date:2009-06-04
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
3HT3
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BU of 3ht3 by Molmil
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus V713P mutant bound to G:dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*CP*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3', 5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3', ...
Authors:Wu, E.Y, Beese, L.S.
Deposit date:2009-06-11
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism.
J.Biol.Chem., 286, 2011
4O0I
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BU of 4o0i by Molmil
Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA
Descriptor: 5'-D(*C*(1TW)P*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', DNA polymerase I, GLYCEROL, ...
Authors:Jiang, S, Gan, J, Sun, H, Huang, Z.
Deposit date:2013-12-13
Release date:2014-12-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with 2'-MeSe-arabino-guanosine derivatized DNA
TO BE PUBLISHED
1D9F
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BU of 1d9f by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA TETRAMER CARRYING 2'-O-(3-AMINOPROPYL)-RNA MODIFICATION 5'-D(TT)-AP(U)-D(T)-3'
Descriptor: DNA POLYMERASE I, DNA/RNA (5'-D(*TP*TP)-R(*(U31)P)-D(*T)-3'), SULFATE ION, ...
Authors:Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M.
Deposit date:1999-10-27
Release date:1999-12-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
6FBI
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BU of 6fbi by Molmil
KlenTaq DNA polymerase in a closed, ternary complex with dGpNHpp bound in the active site
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBE
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BU of 6fbe by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the third primer nucleotide.
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*GP*GP*TP*GP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.589 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBF
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BU of 6fbf by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification upstream at the fourth primer nucleotide.
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*CP*GP*GP*TP*GP*CP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*GP*CP*AP*(OH3)P*CP*GP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBC
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BU of 6fbc by Molmil
KlenTaq DNA polymerase processing a modified primer - bearing the modification at the 3'-terminus of the primer.
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*AP*AP*AP*CP*GP*TP*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ...
Authors:Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2017-12-19
Release date:2018-09-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Snapshots of a modified nucleotide moving through the confines of a DNA polymerase.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1DPI
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BU of 1dpi by Molmil
STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP
Descriptor: DNA POLYMERASE I KLENOW FRAGMENT, ZINC ION
Authors:Beese, L, Ollis, D, Steitz, T.
Deposit date:1987-08-11
Release date:1987-10-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP.
Nature, 313, 1985
1D8Y
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BU of 1d8y by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH DNA
Descriptor: D(T)19 OLIGOMER, DNA POLYMERASE I, SULFATE ION, ...
Authors:Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M.
Deposit date:1999-10-26
Release date:1999-12-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
2XY6
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BU of 2xy6 by Molmil
Crystal structure of a salicylic aldehyde basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-D(*AP*GP*GP*GP*AP*SAYP*GP*GP*TP*CP)-3', ...
Authors:Kaul, C, Mueller, M, Wagner, M, Schneider, S, Carell, T.
Deposit date:2010-11-15
Release date:2011-07-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Reversible Bond Formation Enables the Replication and Amplification of a Crosslinking Salen Complex as an Orthogonal Base Pair.
Nature Chem., 3, 2011
2Y1J
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BU of 2y1j by Molmil
CRYSTAL STRUCTURE OF A R-DIASTEREOMER ANALOGUE OF THE SPORE PHOTOPRODUCT IN COMPLEX WITH FRAGMENT DNA POLYMERASE I FROM BACILLUS STEAROTHERMOPHILUS
Descriptor: 5'-D(*AP*GP*GP*GP*QBTP*THM*GP*GP*TP*CP)-3', 5'-D(*GP*AP*CP*CP*AP*AP*CP*CP*CP*TP)-3', DNA POLYMERASE I, ...
Authors:Heil, K, Schneider, S, Mueller, M, Kneuttinger, A.C, Carell, T.
Deposit date:2010-12-08
Release date:2011-07-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structures and Repair Studies Reveal the Identity and the Base-Pairing Properties of the Uv-Induced Spore Photoproduct DNA Lesion.
Chemistry, 17, 2011
2XO7
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BU of 2xo7 by Molmil
Crystal structure of a dA:O-allylhydroxylamine-dC basepair in complex with fragment DNA polymerase I from Bacillus stearothermophilus
Descriptor: 5'-D(*AP*GP*GP*AP*AP*TP*GP*GP*TP*CP*A)-3', 5'-D(*GP*AP*CP*CP*AP*TP*47C*CP*CP*T)-3', DNA POLYMERASE I, ...
Authors:Muenzel, M, Lercher, L, Mueller, M, Carell, T.
Deposit date:2010-08-10
Release date:2010-09-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Chemical Discrimination between Dc and 5Medc Via Their Hydroxylamine Adducts
Nucleic Acids Res., 38, 2010
1D9D
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BU of 1d9d by Molmil
CRYSTALL STRUCTURE OF THE COMPLEX OF DNA POLYMERASE I KLENOW FRAGMENT WITH SHORT DNA FRAGMENT CARRYING 2'-0-AMINOPROPYL-RNA MODIFICATIONS 5'-D(TCG)-AP(AUC)-3'
Descriptor: 5'-D(*TP*CP*GP)-R(AP*(U31)P*(C31))-3', DNA POLYMERASE I, MAGNESIUM ION, ...
Authors:Teplova, M, Wallace, S.T, Tereshko, V, Minasov, G, Simons, A.M, Cook, P.D, Manoharan, M, Egli, M.
Deposit date:1999-10-27
Release date:1999-12-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proc.Natl.Acad.Sci.USA, 96, 1999
3BDP
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BU of 3bdp by Molmil
DNA POLYMERASE I/DNA COMPLEX
Descriptor: DNA (5'-D(*AP*GP*CP*AP*TP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*GP*CP*2DT)-3'), PROTEIN (DNA POLYMERASE I), ...
Authors:Kiefer, J.R, Mao, C, Beese, L.S.
Deposit date:1997-11-17
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal.
Nature, 391, 1998
4XVM
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BU of 4xvm by Molmil
Binary complex of human polymerase nu and DNA with the finger domain closed and thumb domain rotated out
Descriptor: DNA (5'-D(*CP*TP*AP*GP*CP*GP*TP*CP*A)-3'), DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*G)-3'), DNA polymerase nu
Authors:Lee, Y.-S, Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
4XVI
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BU of 4xvi by Molmil
Binary complex of human polymerase nu and DNA with the finger domain ajar
Descriptor: DNA (5'-D(*AP*CP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*CP*AP*G)-3'), DNA polymerase nu
Authors:Lee, Y.-S, Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
4XIU
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BU of 4xiu by Molmil
Binary complex structure of Klenow fragment of Taq DNA polymerase I707L mutant with DNA containing TTT overhang
Descriptor: DNA polymerase I, thermostable, MAGNESIUM ION, ...
Authors:Wu, E.Y.
Deposit date:2015-01-07
Release date:2015-01-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase.
Biochemistry, 54, 2015
4XVK
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BU of 4xvk by Molmil
Binary complex of human polymerase nu and DNA with the finger domain closed
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA (5'-D(*GP*AP*TP*CP*TP*GP*AP*CP*GP*CP*TP*AP*CP*GP*G)-3'), DNA (5'-D(*TP*CP*CP*GP*TP*AP*GP*CP*GP*TP*CP*A)-3'), ...
Authors:Lee, Y.-S, Yang, W.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Nat.Struct.Mol.Biol., 22, 2015
3KTQ
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BU of 3ktq by Molmil
CRYSTAL STRUCTURE OF AN ACTIVE TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS
Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*DOC)-3'), ...
Authors:Li, Y, Waksman, G.
Deposit date:1998-07-28
Release date:1999-01-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.
EMBO J., 17, 1998

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