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5WS7
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Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-12-05
Release date:2017-01-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
1F3Y
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BU of 1f3y by Molmil
SOLUTION STRUCTURE OF THE NUDIX ENZYME DIADENOSINE TETRAPHOSPHATE HYDROLASE FROM LUPINUS ANGUSTIFOLIUS L.
Descriptor: DIADENOSINE 5',5'''-P1,P4-TETRAPHOSPHATE HYDROLASE
Authors:Swarbrick, J.D, Bashtannyk, T, Maksel, D, Zhang, X.R, Blackburn, G.M, Gayler, K.R, Gooley, P.R.
Deposit date:2000-06-06
Release date:2001-06-06
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L.
J.Mol.Biol., 302, 2000
6YPB
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NUDIX1 hydrolase from Rosa x hybrida
Descriptor: Geranyl diphosphate phosphohydrolase
Authors:Degut, C, Rety, S, Tisne, C, Baudino, S.
Deposit date:2020-04-15
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional diversification in the Nudix hydrolase gene family drives sesquiterpene biosynthesis in Rosa × wichurana.
Plant J., 104, 2020
6YPF
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NUDIX1 hydrolase from Rosa x hybrida in complex with geranyl pyrophosphate
Descriptor: GERANYL DIPHOSPHATE, Geranyl diphosphate phosphohydrolase
Authors:Degut, C, Rety, S, Tisne, C, Baudino, S.
Deposit date:2020-04-16
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Functional diversification in the Nudix hydrolase gene family drives sesquiterpene biosynthesis in Rosa × wichurana.
Plant J., 104, 2020
9B1Z
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BU of 9b1z by Molmil
Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (Apo)
Descriptor: ADP-ribose pyrophosphatase, SODIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-14
Release date:2024-03-27
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (Apo)
To be published
9B22
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Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose and AMP bound)
Descriptor: ADENOSINE MONOPHOSPHATE, ADP-ribose pyrophosphatase, MAGNESIUM ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-14
Release date:2024-03-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose and AMP bound)
To be published
9B21
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Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose bound, Orthorhombic P form)
Descriptor: ADP-ribose pyrophosphatase, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-14
Release date:2024-03-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (ADP Ribose bound, Orthorhombic P form)
To be published
8A0S
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MTH1 in complex with TH013350
Descriptor: 4-[(2-chlorophenyl)methylsulfanyl]-5~{H}-pyrimidin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Liu, H, Scaletti, E, Stenmark, P.
Deposit date:2022-05-30
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:MTH1 in complex with TH013350
To Be Published
8A3A
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MTH1 in complex with TH013074
Descriptor: 4-(4-methylphenyl)-1~{H}-quinazolin-2-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Liu, H, Scaletti, E, Stenmark, P.
Deposit date:2022-06-07
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:MTH1 in complex with TH013074
To Be Published
8A07
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MTH1 in complex with TH001969
Descriptor: 1~{H}-quinazoline-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
Authors:Scaletti, E.R, Narwal, M, Stenmark, P.
Deposit date:2022-05-26
Release date:2023-09-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:MTH1 in complex with TH001969
To Be Published
8A0T
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MTH1 in complex with TH012532
Descriptor: 5-(phenylmethyl)pyrimidine-2,4-diol, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
Authors:Scaletti, E, Stenmark, P.
Deposit date:2022-05-30
Release date:2023-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MTH1 in complex with TH012532
To Be Published
8A34
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MTH1 in complex with TH013071
Descriptor: 5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
Authors:Liu, H, Scaletti, E, Stenmark, P.
Deposit date:2022-06-07
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MTH1 in complex with TH013071
To Be Published
9B20
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BU of 9b20 by Molmil
Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (AMP bound)
Descriptor: ADENOSINE MONOPHOSPHATE, ADP-ribose pyrophosphatase, MAGNESIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-14
Release date:2024-03-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of ADP-ribose diphosphatase from Klebsiella pneumoniae (AMP bound)
To be published
8ZJB
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Oomycete Nudix effectors display WY-Nudix conformations with mRNA decapping activity
Descriptor: Nudix hydrolase domain-containing protein
Authors:Xing, W, Xing, W.
Deposit date:2024-05-14
Release date:2024-07-03
Last modified:2024-08-28
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Oomycete Nudix effectors display WY-Nudix conformation and mRNA decapping activity.
J Integr Plant Biol, 66, 2024
5WWD
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BU of 5wwd by Molmil
Crystal structure of AtNUDX1
Descriptor: AMMONIUM ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Liu, J, Guan, Z, Yan, L, Zou, T, Yin, P.
Deposit date:2016-12-31
Release date:2017-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.386 Å)
Cite:Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
Mol Plant, 11, 2018
5WY6
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Crystal structure of AtNUDX1 (E56A)
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Nudix hydrolase 1, ...
Authors:Liu, J, Guan, Z, Yan, L, Zou, T, Yin, P.
Deposit date:2017-01-11
Release date:2017-11-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.779 Å)
Cite:Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
Mol Plant, 11, 2018
2O5F
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BU of 2o5f by Molmil
Crystal Structure of DR0079 from Deinococcus radiodurans at 1.9 Angstrom Resolution
Descriptor: Putative Nudix hydrolase DR_0079
Authors:Kennedy, M.A, Buchko, G.W, Ni, S, Robinson, H.
Deposit date:2006-12-05
Release date:2007-12-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Functional and Structural Characterization of DR_0079 from Deinococcus radiodurans, a Novel Nudix Hydrolase with a Preference for Cytosine (Deoxy)ribonucleoside 5'-Di- and Triphosphates.
Biochemistry, 47, 2008
2O5W
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BU of 2o5w by Molmil
Structure of the E. coli dihydroneopterin triphosphate pyrophosphohydrolase in complex with Sm+3 and pyrophosphate
Descriptor: PYROPHOSPHATE, SAMARIUM (III) ION, SODIUM ION, ...
Authors:Gabelli, S.B, Bianchet, M.A, Amzel, L.M.
Deposit date:2006-12-06
Release date:2007-08-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Structure, 15, 2007
2PNY
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BU of 2pny by Molmil
Structure of Human Isopentenyl-diphosphate Delta-isomerase 2
Descriptor: CALCIUM ION, GLYCEROL, Isopentenyl-diphosphate Delta-isomerase 2, ...
Authors:Walker, J.R, Davis, T, Butler-Cole, C, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2007-04-25
Release date:2007-05-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structure of the human Isopentenyl-diphosphate Delta-isomerase 2.
To be Published
2O1C
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BU of 2o1c by Molmil
Structure of the E. coli dihydroneopterin triphosphate pyrophosphohydrolase
Descriptor: PYROPHOSPHATE, SULFATE ION, dATP pyrophosphohydrolase
Authors:Gabelli, S.B, Bianchet, M.A, Amzel, L.M.
Deposit date:2006-11-28
Release date:2007-08-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Structure, 15, 2007
2PQV
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Crystal structure of MutT/nudix family protein from Streptococcus pneumoniae
Descriptor: MutT/nudix family protein, PHOSPHATE ION
Authors:Chang, C, Binkowski, T.A, Zhou, M, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-02
Release date:2007-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Crystal structure of MutT/nudix family protein from Streptococcus pneumoniae.
To be Published
2Q9P
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Human diphosphoinositol polyphosphate phosphohydrolase 1, Mg-F complex
Descriptor: CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, FLUORIDE ION, ...
Authors:Thorsell, A.G, Busam, R, Arrowsmith, C.H, Berglund, H, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Holmberg-Schiavone, L, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nordlund, P, Nyman, T, Ogg, D, Sagemark, J, Sundstrom, M, Van den Berg, S, Weigelt, J, Welin, M, Persson, C, Hallberg, B.M, Structural Genomics Consortium (SGC)
Deposit date:2007-06-13
Release date:2007-09-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of human diphosphoinositol phosphatase 1.
Proteins, 77, 2009
8RIY
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Human NUDT5 with ibrutinib derivative
Descriptor: 1-(1-methylpiperidin-4-yl)-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine, ADP-sugar pyrophosphatase
Authors:Balikci-Akil, E, Elkins, J.M, Huber, K.V.M.
Deposit date:2023-12-19
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.
J.Med.Chem., 67, 2024
8T99
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Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with Scyllo-L-1,4-[PP]2-(2,3)IP2, Mg, and Fluoride ion
Descriptor: (1R,2S,3S,4R,5S,6S)-2,3-dihydroxy-5,6-bis(phosphonooxy)cyclohexane-1,4-diyl bis[trihydrogen (diphosphate)], CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2023-06-23
Release date:2023-11-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus.
Embo J., 43, 2024
8TFA
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Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with myo-5-PP-IP4, produced upon myo-(2OH)-IP5 phosphorylation by TvIPK
Descriptor: (1r,2R,3S,4r,5R,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ...
Authors:Zong, G, Wang, H, Shears, S.B.
Deposit date:2023-07-09
Release date:2023-11-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus.
Embo J., 43, 2024

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