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8EKY
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BU of 8eky by Molmil
Cryo-EM structure of the human PRDX4-ErP46 complex
Descriptor: Peroxiredoxin-4, Thioredoxin domain-containing protein 5
Authors:Su, C.C.
Deposit date:2022-09-22
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
8X71
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BU of 8x71 by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-064
Descriptor: Peroxiredoxin-1, methyl 3-[[(2~{R},4~{a}~{S},6~{a}~{R},6~{a}~{S},14~{a}~{S},14~{b}~{R})-2,4~{a},6~{a},6~{a},9,14~{a}-hexamethyl-10-oxidanyl-11-oxidanylidene-1,3,4,5,6,13,14,14~{b}-octahydropicen-2-yl]carbamoylamino]oxetane-3-carboxylate
Authors:Zhang, H, Luo, C.
Deposit date:2023-11-22
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery of a Novel Orally Bioavailable FLT3-PROTAC Degrader for Efficient Treatment of Acute Myeloid Leukemia and Overcoming Resistance of FLT3 Inhibitors.
J.Med.Chem., 67, 2024
8EKW
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BU of 8ekw by Molmil
Cryo-EM structure of human PRDX4
Descriptor: Peroxiredoxin-4
Authors:Su, C.C.
Deposit date:2022-09-22
Release date:2023-05-03
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:High-resolution structural-omics of human liver enzymes.
Cell Rep, 42, 2023
5HQP
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BU of 5hqp by Molmil
Crystal structure of the ERp44-peroxiredoxin 4 complex
Descriptor: Endoplasmic reticulum resident protein 44, Peroxiredoxin-4
Authors:Yang, K, Li, D.F, Wang, X, Wang, C.C.
Deposit date:2016-01-22
Release date:2016-10-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.
Structure, 24, 2016
5EPT
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BU of 5ept by Molmil
Crystal Structure of S. cerevisiae TSA2 in the disulfide state
Descriptor: Peroxiredoxin TSA2
Authors:Nielsen, M.H, Kidmose, R.T, Jenner, L.B.
Deposit date:2015-11-12
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (5 Å)
Cite:Structure of TSA2 reveals novel features of the active-site loop of peroxiredoxins.
Acta Crystallogr D Struct Biol, 72, 2016
5JCG
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BU of 5jcg by Molmil
Structure of Human Peroxiredoxin 3 as three stacked rings
Descriptor: Thioredoxin-dependent peroxide reductase, mitochondrial
Authors:Yewdall, N.A, Gerrard, J.A, Goldstone, D.C.
Deposit date:2016-04-15
Release date:2016-05-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State.
Structure, 24, 2016
6E0G
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BU of 6e0g by Molmil
Mitochondrial peroxiredoxin from Leishmania infantum after heat stress without unfolding client protein
Descriptor: mitochondrial 2-cys-peroxiredoxin
Authors:Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U.
Deposit date:2018-07-06
Release date:2019-02-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Nat Commun, 10, 2019
6E0F
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BU of 6e0f by Molmil
Mitochondrial peroxiredoxin from Leishmania infantum in complex with unfolding client protein after heat stress
Descriptor: mitochondrial 2-cys-peroxiredoxin
Authors:Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U.
Deposit date:2018-07-06
Release date:2019-02-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Nat Commun, 10, 2019
2NVL
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BU of 2nvl by Molmil
Crystal structure of archaeal peroxiredoxin, thioredoxin peroxidase from Aeropyrum pernix K1 (sulfonic acid form)
Descriptor: Probable peroxiredoxin
Authors:Nakamura, T, Yamamoto, T, Abe, M, Matsumura, H, Hagihara, Y, Goto, T, Yamaguchi, T, Inoue, T.
Deposit date:2006-11-13
Release date:2007-11-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
7WEU
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BU of 7weu by Molmil
Crystal structure of Peroxiredoxin I in complex with compound 19-048
Descriptor: Peroxiredoxin-1, UNKNOWN LIGAND
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
7WET
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BU of 7wet by Molmil
Crystal structure of Peroxiredoxin I in complex with the inhibitor Cela
Descriptor: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid, Peroxiredoxin-1
Authors:Zhang, H, Luo, C.
Deposit date:2021-12-24
Release date:2022-12-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.
Signal Transduct Target Ther, 8, 2023
5JLY
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BU of 5jly by Molmil
Structure of Peroxiredoxin-1 from Schistosoma japonicum
Descriptor: Thioredoxin peroxidase-1
Authors:Wu, Q, Huang, F, Zeng, D, Liu, X, Zhao, J, Wang, H, Peng, Y, Li, P, Li, Y.
Deposit date:2016-04-27
Release date:2017-05-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.051 Å)
Cite:Crystal structure of Peroxiredoxin-1 from Schistosoma japonicum
To Be Published
5UKA
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BU of 5uka by Molmil
Salmonella typhimurium AhpC E49Q mutant
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ...
Authors:Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A.
Deposit date:2017-01-20
Release date:2018-01-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
5IJT
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BU of 5ijt by Molmil
Human Peroxiredoxin 2 Oxidized (SS)
Descriptor: Peroxiredoxin-2, ZINC ION
Authors:Haynes, A.C, Bolduc, J.A, Lowther, W.T.
Deposit date:2016-03-02
Release date:2017-09-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
J. Biol. Chem., 293, 2018
2PN8
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BU of 2pn8 by Molmil
Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)
Descriptor: Peroxiredoxin-4
Authors:Pilka, E.S, Kavanagh, K.L, Cooper, C, von Delft, F, Sundstrom, M, Arrowsmith, C.A, Weigelt, J, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-04-24
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase).
To be Published
1PRX
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BU of 1prx by Molmil
HORF6 A NOVEL HUMAN PEROXIDASE ENZYME
Descriptor: HORF6
Authors:Choi, H.-J, Kang, S.W, Yang, C.-H, Rhee, S.G, Ryu, S.-E.
Deposit date:1998-04-03
Release date:1998-06-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution.
Nat.Struct.Biol., 5, 1998
4MA9
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BU of 4ma9 by Molmil
Wild type Salmonella Alkyl Hydroperoxide Reductase C in its substrate-ready conformation
Descriptor: Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, GLYCEROL, ...
Authors:Perkins, A, Karplus, P.A.
Deposit date:2013-08-15
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
Biochemistry, 52, 2013
4MH2
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BU of 4mh2 by Molmil
Crystal structure of Bovine Mitochondrial Peroxiredoxin III
Descriptor: CITRIC ACID, Thioredoxin-dependent peroxide reductase, mitochondrial
Authors:Cao, Z, McGow, D.P, Shepherd, C, Lindsay, J.G.
Deposit date:2013-08-29
Release date:2015-03-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Improved Catenated Structures of Bovine Peroxiredoxin III F190L Reveal Details of Ring-Ring Interactions and a Novel Conformational State.
Plos One, 10, 2015
4MH3
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BU of 4mh3 by Molmil
Crystal structure of Bovine Mitochondrial Peroxiredoxin III
Descriptor: CITRIC ACID, PHOSPHATE ION, Thioredoxin-dependent peroxide reductase, ...
Authors:Cao, Z, McGow, D.P, Shepherd, C, Lindsay, J.G.
Deposit date:2013-08-29
Release date:2015-03-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Improved Catenated Structures of Bovine Peroxiredoxin III F190L Reveal Details of Ring-Ring Interactions and a Novel Conformational State.
Plos One, 10, 2015
2H66
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BU of 2h66 by Molmil
The Crystal Structure of Plasmodium Vivax 2-Cys peroxiredoxin
Descriptor: PV-PF14_0368
Authors:Wernimont, A.K, Dong, A, Zhao, Y, Lew, J, Melone, M, Kozieradzki, I, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC)
Deposit date:2006-05-30
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
2I81
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BU of 2i81 by Molmil
Crystal Structure of Plasmodium vivax 2-Cys Peroxiredoxin, Reduced
Descriptor: 2-Cys Peroxiredoxin
Authors:Artz, J.D, Qiu, W, Dong, A, Lew, J, Ren, H, Zhao, Y, Kozieradski, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC)
Deposit date:2006-08-31
Release date:2006-09-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Plasmodium vivax 2-Cys Peroxiredoxin, Reduced
To be published
2H01
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BU of 2h01 by Molmil
PY00414- Plasmodium yoelii thioredoxin peroxidase I
Descriptor: 2-CYS PEROXIREDOXIN
Authors:Artz, J, Qiu, W, Min, J.R, Dong, A, Lew, J, Melone, M, Alam, Z, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC)
Deposit date:2006-05-12
Release date:2006-05-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of PY00414 - a Plasmodium yoelii thioredoxin peroxidase I
To be Published
2CV4
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BU of 2cv4 by Molmil
Crystal Structure of an Archaeal Peroxiredoxin from the Aerobic Hyperthermophilic Crenarchaeon Aeropyrum pernix K1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ISOPROPYL ALCOHOL, peroxiredoxin
Authors:Mizohata, E, Sakai, H, Fusatomi, E, Terada, T, Murayama, K, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-31
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of an Archaeal Peroxiredoxin from the Aerobic Hyperthermophilic Crenarchaeon Aeropyrum pernix K1
J.Mol.Biol., 354, 2005
5YKJ
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BU of 5ykj by Molmil
Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems
Descriptor: GLYCEROL, Peroxiredoxin PRX1, mitochondrial, ...
Authors:Li, C.C, Yang, J, Yang, M.J, Liu, L, Peng, C.T, Li, T, He, L.H, Song, Y.J, Zhu, Y.B, Zhao, N.L, Zhao, C, Bao, R.
Deposit date:2017-10-14
Release date:2018-10-24
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems
To be published
2C0D
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BU of 2c0d by Molmil
Structure of the mitochondrial 2-cys peroxiredoxin from Plasmodium falciparum
Descriptor: THIOREDOXIN PEROXIDASE 2
Authors:Boucher, I.W, Brannigan, J.A, Wilkinson, A.J, Brzozowski, A.M, Muller, S.
Deposit date:2005-09-01
Release date:2006-11-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural and Biochemical Characterisation of a Mitochondrial Peroxiredoxin from Plasmodium Falciparum
Mol.Microbiol., 61, 2006

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