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5T8T
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BU of 5t8t by Molmil
Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound AMP and Magnesium
Descriptor: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, S-adenosylmethionine synthase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-09-08
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound AMP and Magnesium
to be published
6FCB
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BU of 6fcb by Molmil
Human Methionine Adenosyltransferase II mutant (P115G)
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-20
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FBP
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BU of 6fbp by Molmil
Human Methionine Adenosyltransferase II mutant (S114A) in P22121 crystal form
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-19
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FBN
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BU of 6fbn by Molmil
Human Methionine Adenosyltransferase II mutant (Q113A)
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-19
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
8XB0
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BU of 8xb0 by Molmil
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 292
Descriptor: 1,2-ETHANEDIOL, 7-chloranyl-5-(2-cyclopropylpyridin-3-yl)-8-fluoranyl-2-methyl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ...
Authors:Tong, S.L, Zhang, G.P.
Deposit date:2023-12-05
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
8XAR
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BU of 8xar by Molmil
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with SAM and Compound 54
Descriptor: 1,2-ETHANEDIOL, 7-chloranyl-2-ethyl-5-pyridin-3-yl-pyrazolo[3,4-c]quinolin-4-one, CHLORIDE ION, ...
Authors:Zheng, J.Y, Zhang, G.P, Li, J.J, Tong, S.L.
Deposit date:2023-12-05
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
J.Med.Chem., 67, 2024
5A1G
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BU of 5a1g by Molmil
The structure of Human MAT2A in complex with S-adenosylethionine and PPNP.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, IMIDAZOLE, ...
Authors:Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
Deposit date:2015-04-30
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
5A19
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BU of 5a19 by Molmil
The structure of MAT2A in complex with PPNP.
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
Deposit date:2015-04-28
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
8XAM
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BU of 8xam by Molmil
Co-crystal structure of compound 7 in complex with MAT2A
Descriptor: 2-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenoxy]-~{N}-[3-[7-chloranyl-4-(dimethylamino)-2-oxidanylidene-quinazolin-1-yl]phenyl]ethanamide, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2
Authors:Gao, F, Ding, X.
Deposit date:2023-12-04
Release date:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of novel MAT2A inhibitors by an allosteric site-compatible fragment growing approach.
Bioorg.Med.Chem., 100, 2024
5A1I
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BU of 5a1i by Molmil
The structure of Human MAT2A in complex with SAM, Adenosine, Methionine and PPNP.
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, ADENOSINE, ...
Authors:Murray, B, Antonyuk, S.V, Marina, A, Lu, S.C, Mato, J.M, Hasnain, S.S, Rojas, A.L.
Deposit date:2015-04-30
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
1XRC
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BU of 1xrc by Molmil
CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor: COBALT (II) ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRA
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BU of 1xra by Molmil
CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRB
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BU of 1xrb by Molmil
S-adenosylmethionine synthetase (MAT, ATP: L-methionine S-adenosyltransferase, E.C.2.5.1.6) in which MET residues are replaced with selenomethionine residues (MSE)
Descriptor: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
3TDE
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BU of 3tde by Molmil
Crystal structure of S-adenosylmethionine synthetase Rv1392 from Mycobacterium tuberculosis
Descriptor: S-adenosylmethionine synthase, SODIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-10
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3S82
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BU of 3s82 by Molmil
Structure of a S-adenosylmethionine synthetase from Mycobacterium avium
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-05-27
Release date:2011-06-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3SO4
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BU of 3so4 by Molmil
Methionine-adenosyltransferase from Entamoeba histolytica
Descriptor: ACETATE ION, Methionine-adenosyltransferase
Authors:Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2011-06-29
Release date:2011-07-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Methionine-adenosyltransferase from Entamoeba histolytica
To be Published
3RV2
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BU of 3rv2 by Molmil
Crystal structure of S-adenosylmethionine synthetase from Mycobacterium marinum
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-05-05
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
6FAJ
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BU of 6faj by Molmil
The structure of Human Methionine Adenosyltransferase II in apo state
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, S-adenosylmethionine synthase isoform type-2, ...
Authors:Bradley-Clarke, J, Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-15
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds
Febs J., 2020
6FBO
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BU of 6fbo by Molmil
Human Methionine Adenosyltransferase II mutant (S114A) in I222 crystal form
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, ADENOSINE, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-19
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FCD
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BU of 6fcd by Molmil
Human Methionine Adenosyltransferase II mutant (R264A)
Descriptor: 1,2-ETHANEDIOL, ADENOSINE, DI(HYDROXYETHYL)ETHER, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-12-20
Release date:2019-01-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
6FWB
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BU of 6fwb by Molmil
Crystal structure of Mat2A at 1.79 Angstron resolution
Descriptor: GLYCEROL, S-adenosylmethionine synthase isoform type-2, SODIUM ION, ...
Authors:Zhou, A, Wei, Z, Bai, J, Wang, H.
Deposit date:2018-03-06
Release date:2019-03-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes.
Ebiomedicine, 39, 2019
6G6R
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BU of 6g6r by Molmil
Human Methionine Adenosyltransferase II with SAMe and PPNP
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, 1,2-ETHANEDIOL, MAGNESIUM ION, ...
Authors:Panmanee, J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2018-04-02
Release date:2019-04-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory beta subunit and quinolone-based compounds.
Febs J., 286, 2019
7KCE
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BU of 7kce by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 2
Descriptor: 5-methyl-2,3-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, S-ADENOSYLMETHIONINE, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCC
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BU of 7kcc by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270
Descriptor: 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCF
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BU of 7kcf by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-24512
Descriptor: 1,2-ETHANEDIOL, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, GLYCEROL, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021

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