1AKM
 
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1ACM
 | | ARGININE 54 IN THE ACTIVE SITE OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE IS CRITICAL FOR CATALYSIS: A SITE-SPECIFIC MUTAGENESIS, NMR AND X-RAY CRYSTALLOGRAPHY STUDY | | Descriptor: | ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, ASPARTATE CARBAMOYLTRANSFERASE, CATALYTIC CHAIN, ... | | Authors: | Stevens, R.C, Kantrowitz, E.R, Lipscomb, W.N. | | Deposit date: | 1992-07-08 | | Release date: | 1992-07-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Arginine 54 in the active site of Escherichia coli aspartate transcarbamoylase is critical for catalysis: a site-specific mutagenesis, NMR, and X-ray crystallographic study.
Protein Sci., 1, 1992
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5G1O
 | | Aspartate transcarbamoylase domain of human CAD in apo form | | Descriptor: | 1,2-ETHANEDIOL, CAD protein, GLYCEROL | | Authors: | Ruiz-Ramos, A, Grande-Garcia, A, Moreno-Morcillo, M.D, Ramon-Maiques, S. | | Deposit date: | 2016-03-29 | | Release date: | 2016-06-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
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5G1P
 | | Aspartate transcarbamoylase domain of human CAD bound to carbamoyl phosphate | | Descriptor: | CAD PROTEIN, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER | | Authors: | Ruiz-Ramos, A, Grande-Garcia, A, Moreno-Morcillo, M.D, Ramon-Maiques, S. | | Deposit date: | 2016-03-29 | | Release date: | 2016-06-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
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1A1S
 | | ORNITHINE CARBAMOYLTRANSFERASE FROM PYROCOCCUS FURIOSUS | | Descriptor: | ORNITHINE CARBAMOYLTRANSFERASE | | Authors: | Villeret, V, Clantin, B, Tricot, C, Legrain, C, Roovers, M, Stalon, V, Glansdorff, N, Van Beeumen, J. | | Deposit date: | 1997-12-15 | | Release date: | 1998-06-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1AT1
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5ILQ
 | | Crystal structure of truncated unliganded Aspartate Transcarbamoylase from Plasmodium falciparum | | Descriptor: | Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION | | Authors: | Lunev, S, Bosch, S.S, Batista, F.D.A, Wrenger, C, Groves, M.R. | | Deposit date: | 2016-03-04 | | Release date: | 2016-06-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum.
Acta Crystallogr.,Sect.F, 72, 2016
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3AT1
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3D6N
 | | Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase | | Descriptor: | Aspartate carbamoyltransferase, CITRATE ANION, Dihydroorotase, ... | | Authors: | Edwards, B.F.P. | | Deposit date: | 2008-05-20 | | Release date: | 2009-01-20 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis.
Biochemistry, 48, 2009
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3D7S
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3CSU
 | | CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE | | Descriptor: | CALCIUM ION, PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE) | | Authors: | Beernink, P.T, Endrizzi, J.A, Alber, T, Schachman, H.K. | | Deposit date: | 1999-04-22 | | Release date: | 1999-05-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit.
Proc.Natl.Acad.Sci.USA, 96, 1999
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2P2G
 | | Crystal Structure of Ornithine Carbamoyltransferase from Mycobacterium Tuberculosis (Rv1656): Orthorhombic Form | | Descriptor: | Ornithine carbamoyltransferase, SULFATE ION | | Authors: | Sankaranarayanan, R, Cherney, M.M, Cherney, L.T, Garen, C, Moradian, F, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | Deposit date: | 2007-03-07 | | Release date: | 2007-07-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.
J.Mol.Biol., 375, 2008
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2OTC
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3E2P
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2QG9
 | | Structure of a regulatory subunit mutant D19A of ATCase from E. coli | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION | | Authors: | Stec, B, Williams, M.K, Stieglitz, K.A, Kantrowitz, E.R. | | Deposit date: | 2007-06-28 | | Release date: | 2008-02-19 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors.
Acta Crystallogr.,Sect.D, 63, 2007
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2QGF
 | | Structure of regulatory chain mutant H20A of asparate transcarbamoylase from E. coli | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION | | Authors: | Stec, B, Williams, M.K, Stieglitz, K.A, Kantrowitz, E.R. | | Deposit date: | 2007-06-28 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors.
Acta Crystallogr.,Sect.D, 63, 2007
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2RGW
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3R7L
 | | Crystal Structure of PALA-bound Aspartate Transcarbamoylase from Bacillus subtilis | | Descriptor: | Aspartate carbamoyltransferase, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, PHOSPHATE ION | | Authors: | Harris, K.M, Cockrell, G.M, Puleo, D.E, Kantrowitz, E.R. | | Deposit date: | 2011-03-22 | | Release date: | 2011-06-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.585 Å) | | Cite: | Crystallographic Snapshots of the Complete Catalytic Cycle of the Unregulated Aspartate Transcarbamoylase from Bacillus subtilis.
J.Mol.Biol., 411, 2011
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1SKU
 | | E. coli Aspartate Transcarbamylase 240's Loop Mutant (K244N) | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, MALONATE ION, ... | | Authors: | Alam, N, Stieglitz, K.A, Caban, M.D, Gourinath, S, Tsuruta, H, Kantrowitz, E.R. | | Deposit date: | 2004-03-05 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | 240s Loop Interactions Stabilize the T State of Escherichia coli Aspartate Transcarbamoylase.
J.Biol.Chem., 279, 2004
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3R7D
 | | Crystal Structure of Unliganded Aspartate Transcarbamoylase from Bacillus subtilis | | Descriptor: | Aspartate carbamoyltransferase, PHOSPHATE ION | | Authors: | Puleo, D.E, Harris, K.M, Cockrell, G.M, Kantrowitz, E.R. | | Deposit date: | 2011-03-22 | | Release date: | 2011-06-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.196 Å) | | Cite: | Crystallographic Snapshots of the Complete Catalytic Cycle of the Unregulated Aspartate Transcarbamoylase from Bacillus subtilis.
J.Mol.Biol., 411, 2011
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3SDS
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1TU0
 | | Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, PHOSPHONOACETAMIDE, ... | | Authors: | Stieglitz, K, Stec, B, Baker, D.P, Kantrowitz, E.R. | | Deposit date: | 2004-06-23 | | Release date: | 2004-07-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
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1TTH
 | | Aspartate Transcarbamoylase Catalytic Chain Mutant Glu50Ala Complexed with N-(Phosphonacetyl-L-Aspartate) (PALA) | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ... | | Authors: | Stieglitz, K, Stec, B, Baker, D.P, Kantrowitz, E.R. | | Deposit date: | 2004-06-22 | | Release date: | 2004-07-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
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1TUG
 | | Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide, Malonate, and Cytidine-5-Prime-Triphosphate (CTP) | | Descriptor: | Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Stieglitz, K, Stec, B, Baker, D.P, Kantrowitz, E.R. | | Deposit date: | 2004-06-24 | | Release date: | 2004-07-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
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3TPF
 | | Crystal structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni subsp. jejuni NCTC 11168 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Ornithine carbamoyltransferase | | Authors: | Shabalin, I.G, Onopriyenko, O, Grimshaw, S, Porebski, P.J, Grabowski, M, Savchenko, A, Chruszcz, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-09-07 | | Release date: | 2011-09-21 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of anabolic ornithine carbamoyltransferase from Campylobacter jejuni at 2.7 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
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