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2QK9
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BU of 2qk9 by Molmil
Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid
Descriptor: 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', CITRATE ANION, ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKB
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BU of 2qkb by Molmil
Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid
Descriptor: 1,2-ETHANEDIOL, 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKK
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BU of 2qkk by Molmil
Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-11
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2RPI
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BU of 2rpi by Molmil
The NMR structure of the submillisecond folding intermediate of the Thermus thermophilus ribonuclease H
Descriptor: Ribonuclease H
Authors:Zhou, Z, Feng, H, Bai, Y.
Deposit date:2008-05-16
Release date:2009-03-31
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The high-resolution NMR structure of the early folding intermediate of the Thermus thermophilus ribonuclease H
J.Mol.Biol., 384, 2008
2RN2
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BU of 2rn2 by Molmil
STRUCTURAL DETAILS OF RIBONUCLEASE H FROM ESCHERICHIA COLI AS REFINED TO AN ATOMIC RESOLUTION
Descriptor: RIBONUCLEASE H
Authors:Katayanagi, K, Miyagawa, M, Matsushima, M, Ishikawa, M, Kanaya, S, Nakamura, H, Ikehara, M, Matsuzaki, T, Morikawa, K.
Deposit date:1992-04-15
Release date:1993-10-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution.
J.Mol.Biol., 223, 1992
3H08
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BU of 3h08 by Molmil
Crystal structure of the Ribonuclease H1 from Chlorobium tepidum
Descriptor: MAGNESIUM ION, Rnh (Ribonuclease H)
Authors:Ratcliff, K, Corn, J, Marqusee, S.
Deposit date:2009-04-08
Release date:2009-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure, stability, and folding of ribonuclease H1 from the moderately thermophilic chlorobium tepidum: comparison with thermophilic and mesophilic homologues.
Biochemistry, 48, 2009
3HYF
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BU of 3hyf by Molmil
Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor
Descriptor: 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ...
Authors:Lansdon, E.B, Kirschberg, T.A.
Deposit date:2009-06-22
Release date:2009-10-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J.Med.Chem., 52, 2009
1G15
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BU of 1g15 by Molmil
CO-CRYSTAL OF E. COLI RNASE HI WITH TWO MN2+ IONS BOUND IN THE THE ACTIVE SITE
Descriptor: MANGANESE (II) ION, RIBONUCLEASE HI
Authors:Goedken, E.R, Marqusee, S.
Deposit date:2000-10-10
Release date:2001-03-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Co-crystal of Escherichia coli RNase HI with Mn2+ ions reveals two divalent metals bound in the active site.
J.Biol.Chem., 276, 2001
3K2P
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BU of 3k2p by Molmil
HIV-1 Reverse Transcriptase Isolated RnaseH Domain with the Inhibitor beta-thujaplicinol Bound at the Active Site
Descriptor: 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, MANGANESE (II) ION, Reverse Transcriptase
Authors:Pauly, T.A, Himmel, D.M, Maegley, K, Arnold, E.
Deposit date:2009-09-30
Release date:2010-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
Structure, 17, 2009
1GOB
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BU of 1gob by Molmil
COOPERATIVE STABILIZATION OF ESCHERICHIA COLI RIBONUCLEASE HI BY INSERTION OF GLY-80B AND GLY-77-> ALA SUBSTITUTION
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Nakamura, H, Morikawa, K, Kanaya, S.
Deposit date:1993-05-10
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution.
Biochemistry, 32, 1993
1GOC
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BU of 1goc by Molmil
COOPERATIVE STABILIZATION OF ESCHERICHIA COLI RIBONUCLEASE HI BY INSERTION OF GLY-80B AND GLY-77-> ALA SUBSTITUTION
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Nakamura, H, Morikawa, K, Kanaya, S.
Deposit date:1993-05-10
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution.
Biochemistry, 32, 1993
1F21
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BU of 1f21 by Molmil
DIVALENT METAL COFACTOR BINDING IN THE KINETIC FOLDING TRAJECTORY OF E. COLI RIBONUCLEASE HI
Descriptor: RIBONUCLEASE HI
Authors:Goedken, E.R, Keck, J.L, Berger, J.M, Marqusee, S.
Deposit date:2000-05-22
Release date:2000-12-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Divalent metal cofactor binding in the kinetic folding trajectory of Escherichia coli ribonuclease HI.
Protein Sci., 9, 2000
1GOA
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BU of 1goa by Molmil
COOPERATIVE STABILIZATION OF ESCHERICHIA COLI RIBONUCLEASE HI BY INSERTION OF GLY-80B AND GLY-77-> ALA SUBSTITUTION
Descriptor: RIBONUCLEASE H
Authors:Ishikawa, K, Kimura, S, Nakamura, H, Morikawa, K, Kanaya, S.
Deposit date:1993-05-10
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cooperative stabilization of Escherichia coli ribonuclease HI by insertion of Gly-80b and Gly-77-->Ala substitution.
Biochemistry, 32, 1993
7XIU
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BU of 7xiu by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: MANGANESE (II) ION, Reverse Transcriptase RNase H domain, ZINC ION, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-14
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
7XIT
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BU of 7xit by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: MANGANESE (II) ION, Reverse Transcriptase RNase H domain, ZINC ION, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-14
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
7XJ5
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BU of 7xj5 by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: MANGANESE (II) ION, Reverse Transcriptase RNase H domain, ZINC ION, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-15
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
7XJ7
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BU of 7xj7 by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: MANGANESE (II) ION, Reverse Transcriptase RNase H domain, ZINC ION, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-15
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
7XIS
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BU of 7xis by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: (2-methoxy-4-methoxycarbonyl-phenyl) 5-nitrofuran-2-carboxylate, MANGANESE (II) ION, Reverse Transcriptase RNase H domain, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-14
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
7XJ4
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BU of 7xj4 by Molmil
Crystal structure of engineered HIV-1 Reverse Transcriptase RNase H domain complexed with nitrofuran methoxy(methoxycarbonyl)phenyl ester
Descriptor: MANGANESE (II) ION, Reverse Transcriptase RNase H domain, S-[5-[(E)-2-phenylethenyl]-1,3,4-oxadiazol-2-yl] 5-nitrothiophene-2-carbothioate, ...
Authors:Lu, H, Komukai, Y, Usami, K, Guo, Y, Qiao, X, Nukaga, M, Hoshino, T.
Deposit date:2022-04-15
Release date:2022-04-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
J.Chem.Inf.Model., 62, 2022
3LP3
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BU of 3lp3 by Molmil
p15 HIV RNaseH domain with inhibitor MK3
Descriptor: 3-[4-(diethylamino)phenoxy]-6-(ethoxycarbonyl)-5,8-dihydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-1-ium, MANGANESE (II) ION, p15
Authors:Yan, Y, Munshi, S.K, Prasad, G.S, Su, H.P.
Deposit date:2010-02-04
Release date:2010-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors.
J.Virol., 84, 2010
7VSA
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BU of 7vsa by Molmil
E. coli Ribonuclease HI in complex with two Mg2+
Descriptor: GLYCEROL, MAGNESIUM ION, Ribonuclease HI, ...
Authors:Liao, Z, Oyama, T.
Deposit date:2021-10-26
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Acta Crystallogr D Struct Biol, 78, 2022
4IBN
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BU of 4ibn by Molmil
Crystal structure of LC9-RNase H1, a type 1 RNase H with the type 2 active-site motif
Descriptor: Ribonuclease H
Authors:Nguyen, T.-N, You, D.-J, Kanaya, E, Koga, Y, Kanaya, S.
Deposit date:2012-12-09
Release date:2013-03-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of metagenome-derived LC9-RNase H1 with atypical DEDN active site motif
Febs Lett., 587, 2013
7VSB
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BU of 7vsb by Molmil
E. coli Ribonuclease HI in complex with one Zn2+ (His124 N-delta binding)
Descriptor: Ribonuclease HI, ZINC ION
Authors:Liao, Z, Oyama, T.
Deposit date:2021-10-26
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Acta Crystallogr D Struct Biol, 78, 2022
7VSC
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BU of 7vsc by Molmil
E. coli Ribonuclease HI in complex with one Mg2+ (1)
Descriptor: MAGNESIUM ION, Ribonuclease HI, SULFATE ION
Authors:Liao, Z, Oyama, T.
Deposit date:2021-10-26
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Acta Crystallogr D Struct Biol, 78, 2022
7VSD
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BU of 7vsd by Molmil
E. coli Ribonuclease HI in complex with one Mg2+ (2)
Descriptor: MAGNESIUM ION, Ribonuclease HI, SULFATE ION
Authors:Liao, Z, Oyama, T.
Deposit date:2021-10-26
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Acta Crystallogr D Struct Biol, 78, 2022

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