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9C8V
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BU of 9c8v by Molmil
Human DNA polymerase alpha/primase - CHAPSO (4 mM)
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
Authors:Abe, K.M, Li, G, He, Q, Grant, T, Lim, C.
Deposit date:2024-06-13
Release date:2024-09-04
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Human DNA polymerase alpha/primase - CHAPSO (4 mM)
To Be Published
4QCL
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BU of 4qcl by Molmil
Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA TEMPLATE, ...
Authors:Baranovskiy, A.G, Suwa, Y, Babayeva, N.D, Gu, J, Tahirov, T.H.
Deposit date:2014-05-12
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activity and fidelity of human DNA polymerase alpha depend on primer structure
J.Biol.Chem., 2018
6P1H
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BU of 6p1h by Molmil
Cryo-EM Structure of DNA Polymerase Delta Holoenzyme
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
Authors:Jain, R, Rice, W, Aggarwal, A.K.
Deposit date:2019-05-19
Release date:2019-10-02
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure and dynamics of eukaryotic DNA polymerase delta holoenzyme.
Nat.Struct.Mol.Biol., 26, 2019
5EXR
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BU of 5exr by Molmil
Crystal structure of human primosome
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
Authors:Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
Deposit date:2015-11-24
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J.Biol.Chem., 291, 2016
6AS7
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BU of 6as7 by Molmil
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, COBALT (II) ION, DNA (5'-D(*AP*GP*GP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ...
Authors:Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
Deposit date:2017-08-23
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Activity and fidelity of human DNA polymerase alpha depend on primer structure.
J. Biol. Chem., 293, 2018
1CLQ
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BU of 1clq by Molmil
CRYSTAL STRUCTURE OF A REPLICATION FORK DNA POLYMERASE EDITING COMPLEX AT 2.7 A RESOLUTION
Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*AP*GP*TP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*AP*CP*TP*AP*CP*T)-3'), ...
Authors:Shamoo, Y, Steitz, T.A.
Deposit date:1999-04-30
Release date:1999-10-28
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Building a replisome from interacting pieces: sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex.
Cell(Cambridge,Mass.), 99, 1999
3KD5
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BU of 3kd5 by Molmil
Closed ternary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair and phosphonoformic acid.
Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2009-10-22
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
J.Biol.Chem., 286, 2011
7F4Y
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BU of 7f4y by Molmil
Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ...
Authors:Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J.
Deposit date:2021-06-21
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69.
Front Mol Biosci, 8, 2021
3KD1
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BU of 3kd1 by Molmil
Closed binary complex of an RB69 gp43 fingers domain mutant complexed with an acyclic GMP terminated primer template pair.
Descriptor: DNA (5'-D(*CP*GP*TP*CP*TP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*AP*(4DG))-3'), DNA polymerase, ...
Authors:Zahn, K.E, Doublie, S.
Deposit date:2009-10-22
Release date:2011-04-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase.
J.Biol.Chem., 286, 2011
1Q9Y
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BU of 1q9y by Molmil
CRYSTAL STRUCTURE OF ENTEROBACTERIA PHAGE RB69 GP43 DNA POLYMERASE COMPLEXED WITH 8-OXOGUANOSINE CONTAINING DNA
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-AC(8-OXOGUANOSINE)GGTAAGCAGTCCGCG-3', 5'-GCGGACTGCTTAC(DIDEOXYCYTIDINE)-3', ...
Authors:Freisinger, E, Grollman, A.P, Miller, H, Kisker, C.
Deposit date:2003-08-26
Release date:2004-04-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Lesion (in)tolerance reveals insights into DNA replication fidelity.
Embo J., 23, 2004
1QQC
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BU of 1qqc by Molmil
CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK
Descriptor: DNA POLYMERASE II, MAGNESIUM ION, SULFATE ION
Authors:Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J.
Deposit date:1999-06-02
Release date:1999-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of an archaebacterial DNA polymerase
Structure Fold.Des., 7, 1999
1IH7
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BU of 1ih7 by Molmil
High-Resolution Structure of Apo RB69 DNA Polymerase
Descriptor: DNA POLYMERASE, GUANOSINE, POTASSIUM ION
Authors:Franklin, M.C, Wang, J, Steitz, T.A.
Deposit date:2001-04-18
Release date:2001-06-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of the Replicating Complex of a Pol alpha Family DNA Polymerase
Cell(Cambridge,Mass.), 105, 2001
5H12
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BU of 5h12 by Molmil
Crystal structure of Deep Vent DNA Polymerase
Descriptor: Deep Vent DNA Polymerase
Authors:Hikida, Y, Kimoto, M, Hirao, I, Yokoyama, S.
Deposit date:2016-10-07
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Crystal structure of Deep Vent DNA polymerase.
Biochem. Biophys. Res. Commun., 483, 2017
6WYA
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BU of 6wya by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
1IG9
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BU of 1ig9 by Molmil
Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
Descriptor: 5'-D(*AP*CP*AP*GP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*CP*(DOC))-3', CALCIUM ION, ...
Authors:Franklin, M.C, Wang, J, Steitz, T.A.
Deposit date:2001-04-17
Release date:2001-06-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase
Cell(Cambridge,Mass.), 105, 2001
6WYB
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BU of 6wyb by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with an RNA/DNA hybrid
Descriptor: 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA polymerase, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
1D5A
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BU of 1d5a by Molmil
CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM
Descriptor: MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION
Authors:Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J.
Deposit date:1999-10-06
Release date:2000-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an archaebacterial DNA polymerase.
Structure Fold.Des., 7, 1999
3A2F
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BU of 3a2f by Molmil
Crystal Structure of Pyrococcus furiosus DNA polymerase/PCNA monomer mutant complex
Descriptor: DNA polymerase, DNA polymerase sliding clamp
Authors:Nishida, H, Ishino, Y, Morikawa, K.
Deposit date:2009-05-15
Release date:2009-11-03
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex
To be Published
2XHB
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BU of 2xhb by Molmil
Crystal structure of DNA polymerase from Thermococcus gorgonarius in complex with hypoxanthine-containing DNA
Descriptor: 5'-D(*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', DNA POLYMERASE, HYPOXANTHINE-CONTAINING DNA, ...
Authors:Killelea, T, Ghosh, S, Tan, S.S, Heslop, P, Firbank, S.J, Kool, E.T, Connolly, B.A.
Deposit date:2010-06-14
Release date:2010-07-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Probing the Interaction of Archaeal DNA Polymerases with Deaminated Bases Using X-Ray Crystallography and Non-Hydrogen Bonding Isosteric Base Analogues.
Biochemistry, 49, 2010
2VWK
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BU of 2vwk by Molmil
Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography. V93Q polymerase variant
Descriptor: DNA POLYMERASE, SODIUM ION, SULFATE ION
Authors:Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A.
Deposit date:2008-06-26
Release date:2008-07-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography.
J.Mol.Biol., 381, 2008
1S5J
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BU of 1s5j by Molmil
Insight in DNA Replication: The crystal structure of DNA Polymerase B1 from the archaeon Sulfolobus solfataricus
Descriptor: DNA polymerase I, MAGNESIUM ION, SULFATE ION
Authors:Savino, C, Federici, L, Nastopoulos, V, Johnson, K.A, Pisani, F.M, Rossi, M, Tsernoglou, D.
Deposit date:2004-01-21
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus
Structure, 12, 2004
2VWJ
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BU of 2vwj by Molmil
Uracil Recognition in Archaeal DNA Polymerases Captured by X-ray Crystallography.
Descriptor: 5'-D(*AP*AP*UP*GP*GP*AP*GP*AP*CP*GP *GP*CP*TP*TP*TP*TP*GP*CP*CP*GP*TP*GP*TP*C)-3', DNA POLYMERASE, POTASSIUM ION
Authors:Firbank, S.J, Wardle, J, Heslop, P, Lewis, R.J, Connolly, B.A.
Deposit date:2008-06-25
Release date:2008-07-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Uracil Recognition in Archaeal DNA Polymerases Captured by X-Ray Crystallography.
J.Mol.Biol., 381, 2008
7KC0
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BU of 7kc0 by Molmil
Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ...
Authors:Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E.
Deposit date:2020-10-04
Release date:2020-12-02
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
5IUD
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BU of 5iud by Molmil
Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer
Descriptor: DNA polymerase alpha catalytic subunit, DNA primer, DNA template
Authors:Coloma, J, Aggarwal, A.K.
Deposit date:2016-03-17
Release date:2016-04-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Sci Rep, 6, 2016
1TGO
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BU of 1tgo by Molmil
THERMOSTABLE B TYPE DNA POLYMERASE FROM THERMOCOCCUS GORGONARIUS
Descriptor: PROTEIN (THERMOSTABLE B DNA POLYMERASE)
Authors:Hopfner, K.-P, Eichinger, A, Engh, R.A, Laue, F, Ankenbauer, W, Huber, R, Angerer, B.
Deposit date:1999-02-23
Release date:1999-03-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius.
Proc.Natl.Acad.Sci.USA, 96, 1999

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數據於2024-09-18公開中

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