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3X29
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BU of 3x29 by Molmil
CRYSTAL STRUCTURE of MOUSE CLAUDIN-19 IN COMPLEX with C-TERMINAL FRAGMENT OF CLOSTRIDIUM PERFRINGENS ENTEROTOXIN
Descriptor: Claudin-19, Heat-labile enterotoxin B chain
Authors:Saitoh, Y, Suzuki, H, Tani, K, Nishikawa, K, Irie, K, Ogura, Y, Tamura, A, Tsukita, S, Fujiyoshi, Y.
Deposit date:2014-12-13
Release date:2015-01-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
Science, 347, 2015
4P79
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BU of 4p79 by Molmil
Crystal structure of mouse claudin-15
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Claudin-15
Authors:Suzuki, H, Nishizawa, T, Tani, K, Yamazaki, Y, Tamura, A, Ishitani, R, Dohmae, N, Tsukita, S, Nureki, O, Fujiyoshi, Y.
Deposit date:2014-03-26
Release date:2014-04-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a claudin provides insight into the architecture of tight junctions.
Science, 344, 2014
8U5B
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BU of 8u5b by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1
Descriptor: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2023-09-12
Release date:2023-09-27
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
8U4V
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BU of 8u4v by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody
Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
Authors:Vecchio, A.J.
Deposit date:2023-09-11
Release date:2023-10-25
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment.
Commun Biol, 7, 2024
6AKG
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BU of 6akg by Molmil
Crystal structure of mouse claudin-3 P134G mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin
Descriptor: Claudin-3, Heat-labile enterotoxin B chain
Authors:Nakamura, S, Irie, K, Fujiyoshi, Y.
Deposit date:2018-08-31
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Morphologic determinant of tight junctions revealed by claudin-3 structures.
Nat Commun, 10, 2019
6AKE
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BU of 6ake by Molmil
Crystal structure of mouse claudin-3 in complex with C-terminal fragment of Clostridium perfringens enterotoxin
Descriptor: Claudin-3, Heat-labile enterotoxin B chain
Authors:Nakamura, S, Irie, K, Fujiyoshi, Y.
Deposit date:2018-08-31
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Morphologic determinant of tight junctions revealed by claudin-3 structures.
Nat Commun, 10, 2019
6AKF
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BU of 6akf by Molmil
Crystal structure of mouse claudin-3 P134A mutant in complex with C-terminal fragment of Clostridium perfringens enterotoxin
Descriptor: Claudin-3, Heat-labile enterotoxin B chain
Authors:Nakamura, S, Irie, K, Fujiyoshi, Y.
Deposit date:2018-08-31
Release date:2019-02-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Morphologic determinant of tight junctions revealed by claudin-3 structures.
Nat Commun, 10, 2019
7KP4
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BU of 7kp4 by Molmil
Crystal structure of human claudin-4 in complex with Clostridium perfringens enterotoxin C-terminal domain
Descriptor: Claudin-4, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2020-11-10
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
Proc.Natl.Acad.Sci.USA, 118, 2021
6OV3
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BU of 6ov3 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in open form
Descriptor: Claudin-9, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OV2
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BU of 6ov2 by Molmil
Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin C-terminal domain in closed form
Descriptor: Claudin-9, GLYCEROL, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J, Stroud, R.M.
Deposit date:2019-05-06
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown.
Proc.Natl.Acad.Sci.USA, 116, 2019
7TDM
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BU of 7tdm by Molmil
CryoEM Structure of sFab COP-2 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
Descriptor: COP-2 Fab Heavy chain, COP-2 Fab Light chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2022-01-01
Release date:2022-02-09
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
7TDN
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BU of 7tdn by Molmil
CryoEM Structure of sFab COP-3 Complex with human claudin-4 and Clostridium perfringens enterotoxin C-terminal domain
Descriptor: COP-3 Fab Heavy chain, COP-3 Fab Light chain, Claudin-4, ...
Authors:Vecchio, A.J.
Deposit date:2022-01-01
Release date:2022-02-09
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes.
J.Biol.Chem., 298, 2022
5B2G
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BU of 5b2g by Molmil
Crystal structure of human claudin-4 in complex with C-terminal fragment of Clostridium perfringens enterotoxin
Descriptor: Endolysin,Claudin-4, Heat-labile enterotoxin B chain
Authors:Shinoda, T, Kimura-Someya, T, Shirouzu, M, Yokoyama, S.
Deposit date:2016-01-15
Release date:2016-10-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
Sci Rep, 6, 2016
9CMH
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BU of 9cmh by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin
Descriptor: Claudin-4, Heat-labile enterotoxin B chain
Authors:Vecchio, A.J.
Deposit date:2024-07-15
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4
To Be Published
9CMI
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BU of 9cmi by Molmil
Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody
Descriptor: Anti-Fab Nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ...
Authors:Vecchio, A.J.
Deposit date:2024-07-15
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4
To Be Published
6QKZ
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BU of 6qkz by Molmil
Full length GluA1/2-gamma8 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, ...
Authors:Herguedas, B, Garcia-Nafria, J, Greger, I.G.
Deposit date:2019-01-30
Release date:2019-03-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.
Science, 364, 2019
7QHH
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BU of 7qhh by Molmil
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ...
Authors:Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H.
Deposit date:2021-12-12
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
7QHB
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BU of 7qhb by Molmil
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ...
Authors:Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H.
Deposit date:2021-12-11
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
6QKC
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BU of 6qkc by Molmil
GluA1/2 In complex with auxiliary subunit gamma-8
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 1, ...
Authors:Herguedas, B, Garcia-Nafria, J, Greger, I.G.
Deposit date:2019-01-28
Release date:2019-03-27
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP gamma 8.
Science, 364, 2019
6DM0
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BU of 6dm0 by Molmil
Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DLZ
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BU of 6dlz by Molmil
Open state GluA2 in complex with STZ after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DM1
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BU of 6dm1 by Molmil
Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
7OCA
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BU of 7oca by Molmil
Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCD
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BU of 7ocd by Molmil
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021
7OCE
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BU of 7oce by Molmil
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ...
Authors:Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H.
Deposit date:2021-04-26
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Gating and modulation of a hetero-octameric AMPA glutamate receptor.
Nature, 594, 2021

 

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