Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5WEN
DownloadVisualize
BU of 5wen by Molmil
GluA2 bound to GSG1L in digitonin, state 2
Descriptor: Digitonin, Glutamate receptor 2,Germ cell-specific gene 1-like protein
Authors:Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I.
Deposit date:2017-07-10
Release date:2017-08-02
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
Nature, 549, 2017
6PEQ
DownloadVisualize
BU of 6peq by Molmil
GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Glutamate receptor 2, ...
Authors:Nakagawa, T.
Deposit date:2019-06-20
Release date:2019-12-04
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Science, 366, 2019
5MFW
DownloadVisualize
BU of 5mfw by Molmil
Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-121 at 2.10 A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ...
Authors:Larsen, A.P, Frydenvang, K, Kastrup, J.S.
Deposit date:2016-11-18
Release date:2017-04-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.
Mol. Pharmacol., 91, 2017
6FAZ
DownloadVisualize
BU of 6faz by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.
Descriptor: 1,2-ETHANEDIOL, 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, ...
Authors:Nielsen, L, Laulumaa, S, Kastrup, J.S.
Deposit date:2017-12-18
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.
J. Med. Chem., 61, 2018
6F29
DownloadVisualize
BU of 6f29 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
Descriptor: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2017-11-23
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018
7QHH
DownloadVisualize
BU of 7qhh by Molmil
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, GLUTAMIC ACID, ...
Authors:Herguedas, B, Kohegyi, B, Dohrke, J.N, Watson, J.F, Zhang, D, Ho, H, Shaikh, S, Lape, R, Krieger, J.M, Greger, I.H.
Deposit date:2021-12-12
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
7QHB
DownloadVisualize
BU of 7qhb by Molmil
Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, CYCLOTHIAZIDE, ...
Authors:Herguedas, B, Kohegyi, B, Zhang, D, Greger, I.H.
Deposit date:2021-12-11
Release date:2022-02-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanisms underlying TARP modulation of the GluA1/2-gamma 8 AMPA receptor.
Nat Commun, 13, 2022
4X48
DownloadVisualize
BU of 4x48 by Molmil
Crystal structure of GluR2 ligand-binding core
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ...
Authors:Pandit, J.
Deposit date:2014-12-02
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
J.Med.Chem., 58, 2015
4WXJ
DownloadVisualize
BU of 4wxj by Molmil
Drosophila muscle GluRIIB complex with glutamate
Descriptor: GLUTAMIC ACID, Glutamate receptor IIB,Glutamate receptor IIB
Authors:Dharkar, P, Mayer, M.L.
Deposit date:2014-11-13
Release date:2015-04-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.
Proc.Natl.Acad.Sci.USA, 112, 2015
4UQQ
DownloadVisualize
BU of 4uqq by Molmil
Electron density map of GluK2 desensitized state in complex with 2S,4R-4-methylglutamate
Descriptor: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2, GLUTAMIC ACID
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
4UQJ
DownloadVisualize
BU of 4uqj by Molmil
Cryo-EM density map of GluA2em in complex with ZK200775
Descriptor: GLUTAMATE RECEPTOR 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10.4 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
6IRG
DownloadVisualize
BU of 6irg by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J, Chang, S, Zhang, X, Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
3KEI
DownloadVisualize
BU of 3kei by Molmil
Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with glutamate
Descriptor: GLUTAMIC ACID, Glutamate receptor 4
Authors:Gill, A, Madden, D.R.
Deposit date:2009-10-26
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
J.Neurosci., 30, 2010
3KG2
DownloadVisualize
BU of 3kg2 by Molmil
AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775
Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
Deposit date:2009-10-28
Release date:2009-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Nature, 462, 2009
3KGC
DownloadVisualize
BU of 3kgc by Molmil
Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ...
Authors:Sobolevsky, A.I, Rosconi, M.P, Gouaux, E.
Deposit date:2009-10-28
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Nature, 462, 2009
3RT6
DownloadVisualize
BU of 3rt6 by Molmil
Fluorowillardiine bound to the ligand binding domain of GluA3
Descriptor: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION
Authors:Ahmed, A.H, Oswald, R.E.
Deposit date:2011-05-03
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.836 Å)
Cite:Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
4UQK
DownloadVisualize
BU of 4uqk by Molmil
Electron density map of GluA2em in complex with quisqualate and LY451646
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2
Authors:Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S.
Deposit date:2014-06-24
Release date:2014-08-13
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (16.4 Å)
Cite:Structural Mechanism of Glutamate Receptor Activation and Desensitization
Nature, 514, 2014
6IRA
DownloadVisualize
BU of 6ira by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J, Chang, S, Zhang, X, Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
3RT8
DownloadVisualize
BU of 3rt8 by Molmil
Chlorowillardiine bound to the ligand binding domain of GluA3
Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION
Authors:Ahmed, A.H, Oswald, R.E.
Deposit date:2011-05-03
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.426 Å)
Cite:Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
3RTW
DownloadVisualize
BU of 3rtw by Molmil
Nitrowillardiine bound to the ligand binding domain of GluA2
Descriptor: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION
Authors:Ahmed, A.H, Oswald, R.E.
Deposit date:2011-05-04
Release date:2011-05-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
6IRF
DownloadVisualize
BU of 6irf by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I
Descriptor: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J, Chang, S, Zhang, X, Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
2OJT
DownloadVisualize
BU of 2ojt by Molmil
Structure and mechanism of kainate receptor modulation by anions
Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ...
Authors:Mayer, M.L.
Deposit date:2007-01-14
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and mechanism of kainate receptor modulation by anions.
Neuron, 53, 2007
2PBW
DownloadVisualize
BU of 2pbw by Molmil
Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution
Descriptor: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1
Authors:Hald, H, Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2007-03-29
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
J.Biol.Chem., 282, 2007
2P2A
DownloadVisualize
BU of 2p2a by Molmil
X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution
Descriptor: 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID, GLUTAMIC ACID, Glutamate receptor 2, ...
Authors:Frydenvang, K, Kastrup, J.S, Gajhede, M.
Deposit date:2007-03-07
Release date:2007-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
J.Med.Chem., 50, 2007
5FTH
DownloadVisualize
BU of 5fth by Molmil
Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form)
Descriptor: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ZINC ION
Authors:Nayeem, N, Green, T.
Deposit date:2016-01-13
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distinct Structural Pathways Coordinate the Activation of Ampa Receptor-Auxiliary Subunit Complexes.
Neuron, 89, 2016

225158

건을2024-09-18부터공개중

PDB statisticsPDBj update infoContact PDBjnumon