6Z30
 
 | | Human cation-independent mannose 6-phosphate/ IGF2 receptor domains 9-10 | | 分子名称: | Cation-independent mannose-6-phosphate receptor, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Bochel, A.J, Williams, C, Crump, M.P. | | 登録日 | 2020-05-19 | | 公開日 | 2020-08-19 | | 最終更新日 | 2020-12-09 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Structure, 28, 2020
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6Z31
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6Z32
 | | Human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, SULFATE ION, ... | | 著者 | Bochel, A.J, Williams, C, McCoy, A.J, Hoppe, H, Winter, A.J, Nicholls, R.D, Harlos, K, Jones, Y.E, Berger, I, Hassan, B, Crump, M.P. | | 登録日 | 2020-05-19 | | 公開日 | 2020-08-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | | 主引用文献 | Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Structure, 28, 2020
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6V02
 | | N-terminal 5 domains of CI-MPR | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor | | 著者 | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | 登録日 | 2019-11-18 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Commun Biol, 3, 2020
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6UM1
 | | Structure of M-6-P/IGFII Receptor at pH 4.5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, ... | | 著者 | Wang, R, Qi, X, Li, X. | | 登録日 | 2019-10-08 | | 公開日 | 2020-02-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | | 主引用文献 | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
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6UM2
 | | Structure of M-6-P/IGFII Receptor and IGFII complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II | | 著者 | Wang, R, Qi, X, Li, X. | | 登録日 | 2019-10-08 | | 公開日 | 2020-02-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.32 Å) | | 主引用文献 | Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments
Sci Adv, 6, 2020
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6P8I
 | | N-terminal 5 domains of IGFIIR | | 分子名称: | Cation-independent mannose-6-phosphate receptor, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | 登録日 | 2019-06-07 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Commun Biol, 3, 2020
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5IEI
 | | X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11 | | 分子名称: | 1,2-ETHANEDIOL, Cation-independent mannose-6-phosphate receptor, GLYCEROL, ... | | 著者 | Nicholls, R.D, Williams, C, Strickland, M, Frago, S, Hassan, A.B, Crump, M.P. | | 登録日 | 2016-02-25 | | 公開日 | 2016-05-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2M6T
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-04-09 | | 公開日 | 2014-10-15 | | 最終更新日 | 2016-06-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2M68
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-03-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
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2LLA
 | | NMR solution structure ensemble of domain 11 of the echidna M6P/IGF2R receptor | | 分子名称: | Mannose-6-phosphate/insulin-like growth factor II receptor | | 著者 | Strickland, M, Crump, M.P, Williams, C, Rezgui, D, Ellis, R.Z, Hoppe, H, Frago, S, Prince, S.N, Zaccheo, O.J, Forbes, B.E, Jones, E, Hassan, A.Z, Wattana-Amorn, P. | | 登録日 | 2011-11-05 | | 公開日 | 2012-11-07 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L2G
 | | Solution structure of Opossum Domain 11 | | 分子名称: | IGF2R DOMAIN 11 | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Rezgui, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Bassim, A.H. | | 登録日 | 2010-08-18 | | 公開日 | 2012-02-15 | | 最終更新日 | 2015-02-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L29
 | | Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II | | 分子名称: | Insulin-like growth factor 2 receptor variant, Insulin-like growth factor II | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L2A
 | | Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Williams, C, Hoppe, H, Rezgui, D, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2012-12-12 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.
Science, 338, 2012
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2L21
 | | chicken IGF2R domain 11 | | 分子名称: | Cation-independent mannose-6-phosphate receptor | | 著者 | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | | 登録日 | 2010-08-10 | | 公開日 | 2012-02-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting
To be Published
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2KVB
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2KVA
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2V5N
 | | STRUCTURE OF HUMAN IGF2R DOMAINS 11-12 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | 著者 | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | 登録日 | 2007-07-06 | | 公開日 | 2007-12-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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2V5O
 | | STRUCTURE OF HUMAN IGF2R DOMAINS 11-14 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, CHLORIDE ION | | 著者 | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | 登録日 | 2007-07-06 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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2V5P
 | | COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ... | | 著者 | Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. | | 登録日 | 2007-07-06 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Structure and Functional Analysis of the Igf-II/Igf2R Interaction
Embo J., 27, 2008
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2CNJ
 | | NMR studies on the interaction of Insulin-Growth Factor II (IGF-II) with IGF2R domain 11 | | 分子名称: | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | 著者 | Williams, C, Prince, S, Zaccheo, O, Hassan, A.B, Crosby, J, Crump, M. | | 登録日 | 2006-05-22 | | 公開日 | 2007-05-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Insights Into the Interaction of Insulin-Like Growth Factor 2 with Igf2R Domain 11.
Structure, 15, 2007
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1SZ0
 | | N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | 登録日 | 2004-04-01 | | 公開日 | 2004-06-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
J.Biol.Chem., 279, 2004
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1SYO
 | | N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-alpha-D-mannopyranose, GLYCEROL, ... | | 著者 | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | 登録日 | 2004-04-01 | | 公開日 | 2004-06-29 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
J.Biol.Chem., 279, 2004
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1Q25
 | | Crystal structure of N-terminal 3 domains of CI-MPR | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Olson, L.J, Dahms, N.M, Kim, J.-J.P. | | 登録日 | 2003-07-23 | | 公開日 | 2004-06-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor
Embo J., 23, 2004
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1GQB
 | | HUMAN MIR-RECEPTOR, REPEAT 11 | | 分子名称: | BROMIDE ION, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR | | 著者 | Von Buelow, R, Dauter, M, Dauter, Z, Rajashankar, K.R, Grimme, S, Schmidt, B, Von Figura, K, Uson, I. | | 登録日 | 2001-11-22 | | 公開日 | 2002-12-05 | | 最終更新日 | 2019-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Locating the Anomalous Scatterer Substructures in Halide and Sulfur Phasing
Acta Crystallogr.,Sect.D, 59, 2003
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