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4US3
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Crystal Structure of the bacterial NSS member MhsT in an Occluded Inward-Facing State
分子名称: DODECYL-ALPHA-D-MALTOSIDE, SODIUM ION, TRANSPORTER, ...
著者Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
登録日2014-07-02
公開日2014-09-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.098 Å)
主引用文献A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
4US4
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Crystal Structure of the Bacterial NSS Member MhsT in an Occluded Inward-Facing State (lipidic cubic phase form)
分子名称: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, SODIUM ION, ...
著者Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P.
登録日2014-07-02
公開日2014-09-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters
Nat.Struct.Mol.Biol., 21, 2014
7SK2
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Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation
分子名称: Sodium- and chloride-dependent GABA transporter 1, Tiagabine
著者Gati, C, Motiwala, Z, Aduri, N.G, Shaye, H, Han, G.W, Cherezov, V.
登録日2021-10-19
公開日2022-06-08
最終更新日2022-07-06
実験手法ELECTRON MICROSCOPY (3.82 Å)
主引用文献Structural basis of GABA reuptake inhibition.
Nature, 606, 2022
6NLE
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BU of 6nle by Molmil
X-ray structure of LeuT with V269 deletion
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Navratna, V, Yang, D, Gouaux, E.
登録日2019-01-08
公開日2020-01-15
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.615 Å)
主引用文献Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion inSLC6A3.
Proc.Natl.Acad.Sci.USA, 116, 2019
7TXT
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Structure of human serotonin transporter bound to small molecule '8090 in lipid nanodisc and NaCl
分子名称: 1-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine, 15B8 Fab heavy chain, 15B8 Fab light chain, ...
著者Singh, I, Seth, A, Billesboelle, C.B, Braz, J, Rodriguiz, R.M, Roy, K, Bekele, B, Craik, V, Huang, X.P, Boytsov, D, Lak, P, O'Donnell, H, Sandtner, W, Roth, B.L, Basbaum, A.I, Wetsel, W.C, Manglik, A, Shoichet, B.K, Rudnick, G.
登録日2022-02-09
公開日2023-03-15
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.
Cell, 186, 2023
2A65
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Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
分子名称: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
著者Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E.
登録日2005-07-01
公開日2005-08-02
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
4HOD
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BU of 4hod by Molmil
Crystal structure of LeuT-E290S with bound Cl
分子名称: CHLORIDE ION, LEUCINE, SODIUM ION, ...
著者Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
登録日2012-10-22
公開日2013-05-08
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
8DE4
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Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
分子名称: (2S)-N-methyl-1-phenylpropan-2-amine, 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, ...
著者Yang, D, Gouaux, E.
登録日2022-06-19
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
To be published
4FXZ
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Crystal structure of LeuT-F253A bound to L-leucine from lipid bicelles
分子名称: ACETATE ION, LEUCINE, SODIUM ION, ...
著者Wang, H, Gouaux, E.
登録日2012-07-03
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.601 Å)
主引用文献Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.
Embo Rep., 13, 2012
8DE3
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BU of 8de3 by Molmil
Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
分子名称: 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, D, Gouaux, E.
登録日2022-06-19
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
To Be Published
4FY0
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Crystal structure of LeuT-F253A bound to L-selenomethionine from lipid bicelles
分子名称: SELENOMETHIONINE, SODIUM ION, Transporter
著者Wang, H, Gouaux, E.
登録日2012-07-03
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue.
Embo Rep., 13, 2012
3MPQ
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BU of 3mpq by Molmil
I204R1 mutant of LeuT
分子名称: CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
著者Kroncke, B.M.
登録日2010-04-27
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
3MPN
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F177R1 mutant of LeuT
分子名称: CHLORIDE ION, LEUCINE, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, ...
著者Kroncke, B.M.
登録日2010-04-27
公開日2010-12-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural origins of nitroxide side chain dynamics on membrane protein alpha-helical sites.
Biochemistry, 49, 2010
4HMK
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BU of 4hmk by Molmil
Crystal structure of LeuT-E290S with bound Br
分子名称: BROMIDE ION, LEUCINE, SODIUM ION, ...
著者Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P.
登録日2012-10-18
公開日2013-05-08
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The chloride binding site of Neurotransmitter Sodium Symporters
Proc.Natl.Acad.Sci.USA, 2013
2Q72
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BU of 2q72 by Molmil
Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine
分子名称: 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-05
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2Q6H
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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine
分子名称: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-05
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
2QB4
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Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, LEUCINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-15
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
6W2B
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BU of 6w2b by Molmil
Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, ...
著者Coleman, J.A, Navratna, V, Yang, D.
登録日2020-03-05
公開日2020-03-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.7 Å)
主引用文献Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
6W2C
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Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site
分子名称: 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, I-paroxetine, ...
著者Coleman, J.A, Navratna, V, Yang, D.
登録日2020-03-05
公開日2020-03-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (6.3 Å)
主引用文献Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Elife, 9, 2020
2QJU
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Crystal Structure of an NSS Homolog with Bound Antidepressant
分子名称: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, LEUCINE, ...
著者Zhou, Z, Karpowich, N.K, Wang, D.N, New York Consortium on Membrane Protein Structure (NYCOMPS)
登録日2007-07-09
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
Science, 317, 2007
2QEI
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BU of 2qei by Molmil
Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine
分子名称: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ALANINE, SODIUM ION, ...
著者Singh, S.K, Yamashita, A, Gouaux, E.
登録日2007-06-25
公開日2007-08-21
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
Nature, 448, 2007
5JAG
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BU of 5jag by Molmil
LeuT T354H mutant in the outward-oriented, Na+-free Return State
分子名称: Transporter, octyl beta-D-glucopyranoside
著者Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P.
登録日2016-04-12
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.
Nat Commun, 7, 2016
8FT5
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Crystal structure of LeuT soaked with Crown-5
分子名称: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
著者Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
登録日2023-01-11
公開日2023-11-22
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
8FT4
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Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV
分子名称: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ...
著者Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q.
登録日2023-01-11
公開日2023-11-22
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter
To be Published
5JAE
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LeuT in the outward-oriented, Na+-free return state, P21 form at pH 6.5
分子名称: Transporter, octyl beta-D-glucopyranoside
著者Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P.
登録日2016-04-12
公開日2016-06-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.
Nat Commun, 7, 2016

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