Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9VEF

The cryo-EM structure of human Piezo2-MDFIC complex (composite map)

Functional Information from GO Data
ChainGOidnamespacecontents
A0002000biological_processdetection of renal blood flow
A0005886cellular_componentplasma membrane
A0006091biological_processgeneration of precursor metabolites and energy
A0006812biological_processmonoatomic cation transport
A0008218biological_processbioluminescence
A0009612biological_processresponse to mechanical stimulus
A0032420cellular_componentstereocilium
A0032437cellular_componentcuticular plate
A0032809cellular_componentneuronal cell body membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0050974biological_processdetection of mechanical stimulus involved in sensory perception
A0050982biological_processdetection of mechanical stimulus
A0071260biological_processcellular response to mechanical stimulus
A0098655biological_processmonoatomic cation transmembrane transport
A0140135molecular_functionmechanosensitive monoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0010468biological_processregulation of gene expression
B0030111biological_processregulation of Wnt signaling pathway
B0030332molecular_functioncyclin binding
B0030957molecular_functionTat protein binding
B0042308biological_processnegative regulation of protein import into nucleus
B0045892biological_processnegative regulation of DNA-templated transcription
B0045893biological_processpositive regulation of DNA-templated transcription
B0046328biological_processregulation of JNK cascade
B0050434biological_processpositive regulation of viral transcription
B0140297molecular_functionDNA-binding transcription factor binding
C0002000biological_processdetection of renal blood flow
C0005886cellular_componentplasma membrane
C0006091biological_processgeneration of precursor metabolites and energy
C0006812biological_processmonoatomic cation transport
C0008218biological_processbioluminescence
C0009612biological_processresponse to mechanical stimulus
C0032420cellular_componentstereocilium
C0032437cellular_componentcuticular plate
C0032809cellular_componentneuronal cell body membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0050974biological_processdetection of mechanical stimulus involved in sensory perception
C0050982biological_processdetection of mechanical stimulus
C0071260biological_processcellular response to mechanical stimulus
C0098655biological_processmonoatomic cation transmembrane transport
C0140135molecular_functionmechanosensitive monoatomic cation channel activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0010468biological_processregulation of gene expression
D0030111biological_processregulation of Wnt signaling pathway
D0030332molecular_functioncyclin binding
D0030957molecular_functionTat protein binding
D0042308biological_processnegative regulation of protein import into nucleus
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0046328biological_processregulation of JNK cascade
D0050434biological_processpositive regulation of viral transcription
D0140297molecular_functionDNA-binding transcription factor binding
E0002000biological_processdetection of renal blood flow
E0005886cellular_componentplasma membrane
E0006091biological_processgeneration of precursor metabolites and energy
E0006812biological_processmonoatomic cation transport
E0008218biological_processbioluminescence
E0009612biological_processresponse to mechanical stimulus
E0032420cellular_componentstereocilium
E0032437cellular_componentcuticular plate
E0032809cellular_componentneuronal cell body membrane
E0034220biological_processmonoatomic ion transmembrane transport
E0042391biological_processregulation of membrane potential
E0050974biological_processdetection of mechanical stimulus involved in sensory perception
E0050982biological_processdetection of mechanical stimulus
E0071260biological_processcellular response to mechanical stimulus
E0098655biological_processmonoatomic cation transmembrane transport
E0140135molecular_functionmechanosensitive monoatomic cation channel activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0010468biological_processregulation of gene expression
F0030111biological_processregulation of Wnt signaling pathway
F0030332molecular_functioncyclin binding
F0030957molecular_functionTat protein binding
F0042308biological_processnegative regulation of protein import into nucleus
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0046328biological_processregulation of JNK cascade
F0050434biological_processpositive regulation of viral transcription
F0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CcCcgDemGDdC
ChainResidueDetails
BCYS201-CYS212
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=17","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues492
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues27
DetailsTransmembrane: {"description":"Helical; Name=18","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues813
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=19","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=20","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=21","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsTransmembrane: {"description":"Helical; Name=22","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=23","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=24","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=25","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=26","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues75
DetailsTransmembrane: {"description":"Helical; Name=27","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=28","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=29","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues33
DetailsTransmembrane: {"description":"Helical; Name=30","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=31","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=32","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=33","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=34","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues69
DetailsTransmembrane: {"description":"Helical; Name=35","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues66
DetailsTransmembrane: {"description":"Helical; Name=36","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues69
DetailsTransmembrane: {"description":"Helical; Name=37","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=38","evidences":[{"source":"UniProtKB","id":"Q8CD54","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

256448

PDB entries from 2026-07-15

PDB statisticsPDBj update infoContact PDBjnumon