Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9TI8

Staphylococcus aureus 50S ribosome in complex with RRF, EF-G and fusidic acid (50S-RRF-EF-G-FA)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0006412	biological_process	translation
1	0019843	molecular_function	rRNA binding
2	0003735	molecular_function	structural constituent of ribosome
2	0006412	biological_process	translation
2	0022625	cellular_component	cytosolic large ribosomal subunit
3	0003735	molecular_function	structural constituent of ribosome
3	0005737	cellular_component	cytoplasm
3	0006412	biological_process	translation
3	0022625	cellular_component	cytosolic large ribosomal subunit
4	0003735	molecular_function	structural constituent of ribosome
4	0006412	biological_process	translation
5	0003735	molecular_function	structural constituent of ribosome
5	0006412	biological_process	translation
6	0005737	cellular_component	cytoplasm
6	0006412	biological_process	translation
6	0019843	molecular_function	rRNA binding
7	0006412	biological_process	translation
8	0003735	molecular_function	structural constituent of ribosome
8	0006412	biological_process	translation
8	0022625	cellular_component	cytosolic large ribosomal subunit
9	0005737	cellular_component	cytoplasm
9	0006412	biological_process	translation
9	0008270	molecular_function	zinc ion binding
9	0019843	molecular_function	rRNA binding
9	0022625	cellular_component	cytosolic large ribosomal subunit
C	0005737	cellular_component	cytoplasm
C	0006415	biological_process	translational termination
C	0032790	biological_process	ribosome disassembly
C	0043023	molecular_function	ribosomal large subunit binding
E	0003746	molecular_function	translation elongation factor activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0006414	biological_process	translational elongation
E	0032790	biological_process	ribosome disassembly
G	0002181	biological_process	cytoplasmic translation
G	0003735	molecular_function	structural constituent of ribosome
G	0006412	biological_process	translation
G	0015934	cellular_component	large ribosomal subunit
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
H	0003735	molecular_function	structural constituent of ribosome
H	0006412	biological_process	translation
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0006417	biological_process	regulation of translation
I	0019843	molecular_function	rRNA binding
I	0022625	cellular_component	cytosolic large ribosomal subunit
J	0000049	molecular_function	tRNA binding
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
K	0002181	biological_process	cytoplasmic translation
K	0003723	molecular_function	RNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0006412	biological_process	translation
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
M	0003729	molecular_function	mRNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0017148	biological_process	negative regulation of translation
M	0022625	cellular_component	cytosolic large ribosomal subunit
N	0003735	molecular_function	structural constituent of ribosome
N	0006412	biological_process	translation
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	0070180	molecular_function	large ribosomal subunit rRNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0006412	biological_process	translation
O	0019843	molecular_function	rRNA binding
O	0022625	cellular_component	cytosolic large ribosomal subunit
P	0003735	molecular_function	structural constituent of ribosome
P	0006412	biological_process	translation
P	0019843	molecular_function	rRNA binding
P	0022625	cellular_component	cytosolic large ribosomal subunit
Q	0003735	molecular_function	structural constituent of ribosome
Q	0006412	biological_process	translation
Q	0022625	cellular_component	cytosolic large ribosomal subunit
R	0005737	cellular_component	cytoplasm
R	0006412	biological_process	translation
R	0008097	molecular_function	5S rRNA binding
R	0019843	molecular_function	rRNA binding
R	0022625	cellular_component	cytosolic large ribosomal subunit
S	0003735	molecular_function	structural constituent of ribosome
S	0006412	biological_process	translation
S	0022625	cellular_component	cytosolic large ribosomal subunit
T	0000027	biological_process	ribosomal large subunit assembly
T	0003735	molecular_function	structural constituent of ribosome
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
U	0003735	molecular_function	structural constituent of ribosome
U	0005737	cellular_component	cytoplasm
U	0006412	biological_process	translation
U	0019843	molecular_function	rRNA binding
U	0022625	cellular_component	cytosolic large ribosomal subunit
V	0003735	molecular_function	structural constituent of ribosome
V	0006412	biological_process	translation
V	0019843	molecular_function	rRNA binding
V	0022625	cellular_component	cytosolic large ribosomal subunit
W	0003735	molecular_function	structural constituent of ribosome
W	0006412	biological_process	translation
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
X	0003735	molecular_function	structural constituent of ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
X	0022625	cellular_component	cytosolic large ribosomal subunit
Y	0003723	molecular_function	RNA binding
Y	0006412	biological_process	translation
Y	0008097	molecular_function	5S rRNA binding
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Z	0003735	molecular_function	structural constituent of ribosome
Z	0006412	biological_process	translation
Z	0022625	cellular_component	cytosolic large ribosomal subunit

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVIVrtksgvrrn.DGsyikFdeNacVI

Chain	Residue	Details
N	ALA60-ILE86

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DWmeqEQdRGITItsA

Chain	Residue	Details
E	ASP51-ALA66

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LelITGQkpLvTkAKkS

Chain	Residue	Details
J	LEU57-SER73

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KrfRpRAqGRasainkrtSHITIvV

Chain	Residue	Details
V	LYS83-VAL107

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGSVmNPnD

Chain	Residue	Details
G	PRO218-ASP229

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FvagdviDvtGvSkGKGfqGaikR

Chain	Residue	Details
H	PHE110-ARG133

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KILGnGsLdkk..LtVkahkFSasAaeaIdakG

Chain	Residue	Details
O	LYS110-GLY140

site_id	PS00525
Number of Residues	9
Details	RIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGI

Chain	Residue	Details
K	PRO154-ILE162

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YiTtKNkrnnPerIEmkKYC

Chain	Residue	Details
6	TYR17-CYS36

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRgGKVWIKIFP

Chain	Residue	Details
P	LYS59-PRO70

site_id	PS00591
Number of Residues	11
Details	GH10_1 Glycosyl hydrolases family 10 (GH10) active site. AIEVdITELNI

Chain	Residue	Details
Y	ALA140-ILE150

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGaGKGavegW

Chain	Residue	Details
P	ARG82-TRP93

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. IKGMLPstrl.GEkqgkkLfVYgG

Chain	Residue	Details
M	ILE106-GLY128

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTYQpnkrkHskvh.GFrkR

Chain	Residue	Details
7	LYS3-ARG22

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CekCkvIkRkgkVmViCenp.KHkQrQ

Chain	Residue	Details
9	CYS11-GLN36

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GsILyRQRGtkiypG

Chain	Residue	Details
Z	GLY42-GLY56

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTHrGAaKRVkrtasgqlkrsraft.SH

Chain	Residue	Details
8	LYS5-HIS31

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KrdfRkLWITRINaaaR

Chain	Residue	Details
T	LYS54-ARG70

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGKVR.RAKLYYLR

Chain	Residue	Details
S	VAL88-ARG103

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDnVkVIaGkdKGke.GkV

Chain	Residue	Details
X	GLY6-VAL23

site_id	PS01143
Number of Residues	22
Details	RIBOSOMAL_L31 Ribosomal protein L31 signature. DIssdsHPFYTgrqkfaaad....GR

Chain	Residue	Details
4	ASP49-ARG70

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IeTTeaRaKevrsvvEkLITlGK

Chain	Residue	Details
Q	ILE30-LYS52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	201
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00054","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	17
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)