9OU8
Crystal structure of hUGDH Dimer-A104L/A136M complexed with UDP-Xyl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001702 | biological_process | gastrulation with mouth forming second |
| A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0048666 | biological_process | neuron development |
| A | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001702 | biological_process | gastrulation with mouth forming second |
| B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0048666 | biological_process | neuron development |
| B | 0050650 | biological_process | chondroitin sulfate proteoglycan biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Region: {"description":"Allosteric switch region","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21961565","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25478983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30457329","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27966912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TJH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21984906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3TDK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22123821","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23106432","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21502315","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21595445","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2QG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KHU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PRJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EDF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
