9O04

CryoEM structure of the FBXO42-CCDC6-PP2Ac degradasome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0007010	biological_process	cytoskeleton organization
A	0042802	molecular_function	identical protein binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0007010	biological_process	cytoskeleton organization
B	0042802	molecular_function	identical protein binding
C	0005515	molecular_function	protein binding
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	0000159	cellular_component	protein phosphatase type 2A complex
D	0000278	biological_process	mitotic cell cycle
D	0000775	cellular_component	chromosome, centromeric region
D	0000785	cellular_component	chromatin
D	0000922	cellular_component	spindle pole
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0004725	molecular_function	protein tyrosine phosphatase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006470	biological_process	protein dephosphorylation
D	0008287	cellular_component	protein serine/threonine phosphatase complex
D	0010288	biological_process	response to lead ion
D	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
D	0015630	cellular_component	microtubule cytoskeleton
D	0016020	cellular_component	membrane
D	0016180	biological_process	snRNA processing
D	0031113	biological_process	regulation of microtubule polymerization
D	0032039	cellular_component	integrator complex
D	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
D	0035330	biological_process	regulation of hippo signaling
D	0035331	biological_process	negative regulation of hippo signaling
D	0035556	biological_process	intracellular signal transduction
D	0040008	biological_process	regulation of growth
D	0043029	biological_process	T cell homeostasis
D	0045121	cellular_component	membrane raft
D	0045202	cellular_component	synapse
D	0045595	biological_process	regulation of cell differentiation
D	0046982	molecular_function	protein heterodimerization activity
D	0048156	molecular_function	tau protein binding
D	0050811	molecular_function	GABA receptor binding
D	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D	0070062	cellular_component	extracellular exosome
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090443	cellular_component	FAR/SIN/STRIPAK complex
D	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
D	0160232	cellular_component	INTAC complex
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
D	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
D	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
D	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	0000159	cellular_component	protein phosphatase type 2A complex
E	0000278	biological_process	mitotic cell cycle
E	0000775	cellular_component	chromosome, centromeric region
E	0000785	cellular_component	chromatin
E	0000922	cellular_component	spindle pole
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0004722	molecular_function	protein serine/threonine phosphatase activity
E	0004725	molecular_function	protein tyrosine phosphatase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006470	biological_process	protein dephosphorylation
E	0008287	cellular_component	protein serine/threonine phosphatase complex
E	0010288	biological_process	response to lead ion
E	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
E	0015630	cellular_component	microtubule cytoskeleton
E	0016020	cellular_component	membrane
E	0016180	biological_process	snRNA processing
E	0031113	biological_process	regulation of microtubule polymerization
E	0032039	cellular_component	integrator complex
E	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
E	0035330	biological_process	regulation of hippo signaling
E	0035331	biological_process	negative regulation of hippo signaling
E	0035556	biological_process	intracellular signal transduction
E	0040008	biological_process	regulation of growth
E	0043029	biological_process	T cell homeostasis
E	0045121	cellular_component	membrane raft
E	0045202	cellular_component	synapse
E	0045595	biological_process	regulation of cell differentiation
E	0046982	molecular_function	protein heterodimerization activity
E	0048156	molecular_function	tau protein binding
E	0050811	molecular_function	GABA receptor binding
E	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0070062	cellular_component	extracellular exosome
E	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
E	0090443	cellular_component	FAR/SIN/STRIPAK complex
E	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
E	0160232	cellular_component	INTAC complex
E	0160240	biological_process	RNA polymerase II transcription initiation surveillance
E	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
E	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
E	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
E	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	0005515	molecular_function	protein binding
G	0019005	cellular_component	SCF ubiquitin ligase complex
G	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
G	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
I	0000159	cellular_component	protein phosphatase type 2A complex
I	0000278	biological_process	mitotic cell cycle
I	0000775	cellular_component	chromosome, centromeric region
I	0000785	cellular_component	chromatin
I	0000922	cellular_component	spindle pole
I	0004721	molecular_function	phosphoprotein phosphatase activity
I	0004722	molecular_function	protein serine/threonine phosphatase activity
I	0004725	molecular_function	protein tyrosine phosphatase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0006470	biological_process	protein dephosphorylation
I	0008287	cellular_component	protein serine/threonine phosphatase complex
I	0010288	biological_process	response to lead ion
I	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0016180	biological_process	snRNA processing
I	0031113	biological_process	regulation of microtubule polymerization
I	0032039	cellular_component	integrator complex
I	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
I	0035330	biological_process	regulation of hippo signaling
I	0035331	biological_process	negative regulation of hippo signaling
I	0035556	biological_process	intracellular signal transduction
I	0040008	biological_process	regulation of growth
I	0043029	biological_process	T cell homeostasis
I	0045121	cellular_component	membrane raft
I	0045202	cellular_component	synapse
I	0045595	biological_process	regulation of cell differentiation
I	0046982	molecular_function	protein heterodimerization activity
I	0048156	molecular_function	tau protein binding
I	0050811	molecular_function	GABA receptor binding
I	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
I	0070062	cellular_component	extracellular exosome
I	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
I	0090443	cellular_component	FAR/SIN/STRIPAK complex
I	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
I	0160232	cellular_component	INTAC complex
I	0160240	biological_process	RNA polymerase II transcription initiation surveillance
I	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
I	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
I	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
I	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
I	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
I	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
J	0000159	cellular_component	protein phosphatase type 2A complex
J	0000278	biological_process	mitotic cell cycle
J	0000775	cellular_component	chromosome, centromeric region
J	0000785	cellular_component	chromatin
J	0000922	cellular_component	spindle pole
J	0004721	molecular_function	phosphoprotein phosphatase activity
J	0004722	molecular_function	protein serine/threonine phosphatase activity
J	0004725	molecular_function	protein tyrosine phosphatase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0006470	biological_process	protein dephosphorylation
J	0008287	cellular_component	protein serine/threonine phosphatase complex
J	0010288	biological_process	response to lead ion
J	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0016180	biological_process	snRNA processing
J	0031113	biological_process	regulation of microtubule polymerization
J	0032039	cellular_component	integrator complex
J	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
J	0035330	biological_process	regulation of hippo signaling
J	0035331	biological_process	negative regulation of hippo signaling
J	0035556	biological_process	intracellular signal transduction
J	0040008	biological_process	regulation of growth
J	0043029	biological_process	T cell homeostasis
J	0045121	cellular_component	membrane raft
J	0045202	cellular_component	synapse
J	0045595	biological_process	regulation of cell differentiation
J	0046982	molecular_function	protein heterodimerization activity
J	0048156	molecular_function	tau protein binding
J	0050811	molecular_function	GABA receptor binding
J	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0070062	cellular_component	extracellular exosome
J	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
J	0090443	cellular_component	FAR/SIN/STRIPAK complex
J	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
J	0160232	cellular_component	INTAC complex
J	0160240	biological_process	RNA polymerase II transcription initiation surveillance
J	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
J	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
J	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
J	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
J	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
J	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
K	0000159	cellular_component	protein phosphatase type 2A complex
K	0000278	biological_process	mitotic cell cycle
K	0000775	cellular_component	chromosome, centromeric region
K	0000785	cellular_component	chromatin
K	0000922	cellular_component	spindle pole
K	0004721	molecular_function	phosphoprotein phosphatase activity
K	0004722	molecular_function	protein serine/threonine phosphatase activity
K	0004725	molecular_function	protein tyrosine phosphatase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0006470	biological_process	protein dephosphorylation
K	0008287	cellular_component	protein serine/threonine phosphatase complex
K	0010288	biological_process	response to lead ion
K	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0016180	biological_process	snRNA processing
K	0031113	biological_process	regulation of microtubule polymerization
K	0032039	cellular_component	integrator complex
K	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
K	0035330	biological_process	regulation of hippo signaling
K	0035331	biological_process	negative regulation of hippo signaling
K	0035556	biological_process	intracellular signal transduction
K	0040008	biological_process	regulation of growth
K	0043029	biological_process	T cell homeostasis
K	0045121	cellular_component	membrane raft
K	0045202	cellular_component	synapse
K	0045595	biological_process	regulation of cell differentiation
K	0046982	molecular_function	protein heterodimerization activity
K	0048156	molecular_function	tau protein binding
K	0050811	molecular_function	GABA receptor binding
K	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
K	0070062	cellular_component	extracellular exosome
K	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
K	0090443	cellular_component	FAR/SIN/STRIPAK complex
K	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
K	0160232	cellular_component	INTAC complex
K	0160240	biological_process	RNA polymerase II transcription initiation surveillance
K	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
K	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
K	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
K	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
K	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
K	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
L	0000159	cellular_component	protein phosphatase type 2A complex
L	0000278	biological_process	mitotic cell cycle
L	0000775	cellular_component	chromosome, centromeric region
L	0000785	cellular_component	chromatin
L	0000922	cellular_component	spindle pole
L	0004721	molecular_function	phosphoprotein phosphatase activity
L	0004722	molecular_function	protein serine/threonine phosphatase activity
L	0004725	molecular_function	protein tyrosine phosphatase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006470	biological_process	protein dephosphorylation
L	0008287	cellular_component	protein serine/threonine phosphatase complex
L	0010288	biological_process	response to lead ion
L	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
L	0015630	cellular_component	microtubule cytoskeleton
L	0016020	cellular_component	membrane
L	0016180	biological_process	snRNA processing
L	0031113	biological_process	regulation of microtubule polymerization
L	0032039	cellular_component	integrator complex
L	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
L	0035330	biological_process	regulation of hippo signaling
L	0035331	biological_process	negative regulation of hippo signaling
L	0035556	biological_process	intracellular signal transduction
L	0040008	biological_process	regulation of growth
L	0043029	biological_process	T cell homeostasis
L	0045121	cellular_component	membrane raft
L	0045202	cellular_component	synapse
L	0045595	biological_process	regulation of cell differentiation
L	0046982	molecular_function	protein heterodimerization activity
L	0048156	molecular_function	tau protein binding
L	0050811	molecular_function	GABA receptor binding
L	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
L	0070062	cellular_component	extracellular exosome
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090443	cellular_component	FAR/SIN/STRIPAK complex
L	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
L	0160232	cellular_component	INTAC complex
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
L	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
L	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
L	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
L	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
L	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
M	0000159	cellular_component	protein phosphatase type 2A complex
M	0000278	biological_process	mitotic cell cycle
M	0000775	cellular_component	chromosome, centromeric region
M	0000785	cellular_component	chromatin
M	0000922	cellular_component	spindle pole
M	0004721	molecular_function	phosphoprotein phosphatase activity
M	0004722	molecular_function	protein serine/threonine phosphatase activity
M	0004725	molecular_function	protein tyrosine phosphatase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0006470	biological_process	protein dephosphorylation
M	0008287	cellular_component	protein serine/threonine phosphatase complex
M	0010288	biological_process	response to lead ion
M	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
M	0015630	cellular_component	microtubule cytoskeleton
M	0016020	cellular_component	membrane
M	0016180	biological_process	snRNA processing
M	0031113	biological_process	regulation of microtubule polymerization
M	0032039	cellular_component	integrator complex
M	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
M	0035330	biological_process	regulation of hippo signaling
M	0035331	biological_process	negative regulation of hippo signaling
M	0035556	biological_process	intracellular signal transduction
M	0040008	biological_process	regulation of growth
M	0043029	biological_process	T cell homeostasis
M	0045121	cellular_component	membrane raft
M	0045202	cellular_component	synapse
M	0045595	biological_process	regulation of cell differentiation
M	0046982	molecular_function	protein heterodimerization activity
M	0048156	molecular_function	tau protein binding
M	0050811	molecular_function	GABA receptor binding
M	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
M	0070062	cellular_component	extracellular exosome
M	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
M	0090443	cellular_component	FAR/SIN/STRIPAK complex
M	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
M	0160232	cellular_component	INTAC complex
M	0160240	biological_process	RNA polymerase II transcription initiation surveillance
M	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
M	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
M	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
M	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
M	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
M	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
N	0000159	cellular_component	protein phosphatase type 2A complex
N	0000278	biological_process	mitotic cell cycle
N	0000775	cellular_component	chromosome, centromeric region
N	0000785	cellular_component	chromatin
N	0000922	cellular_component	spindle pole
N	0004721	molecular_function	phosphoprotein phosphatase activity
N	0004722	molecular_function	protein serine/threonine phosphatase activity
N	0004725	molecular_function	protein tyrosine phosphatase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0006470	biological_process	protein dephosphorylation
N	0008287	cellular_component	protein serine/threonine phosphatase complex
N	0010288	biological_process	response to lead ion
N	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
N	0015630	cellular_component	microtubule cytoskeleton
N	0016020	cellular_component	membrane
N	0016180	biological_process	snRNA processing
N	0031113	biological_process	regulation of microtubule polymerization
N	0032039	cellular_component	integrator complex
N	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
N	0035330	biological_process	regulation of hippo signaling
N	0035331	biological_process	negative regulation of hippo signaling
N	0035556	biological_process	intracellular signal transduction
N	0040008	biological_process	regulation of growth
N	0043029	biological_process	T cell homeostasis
N	0045121	cellular_component	membrane raft
N	0045202	cellular_component	synapse
N	0045595	biological_process	regulation of cell differentiation
N	0046982	molecular_function	protein heterodimerization activity
N	0048156	molecular_function	tau protein binding
N	0050811	molecular_function	GABA receptor binding
N	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0070062	cellular_component	extracellular exosome
N	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
N	0090443	cellular_component	FAR/SIN/STRIPAK complex
N	0097706	biological_process	vascular endothelial cell response to oscillatory fluid shear stress
N	0160232	cellular_component	INTAC complex
N	0160240	biological_process	RNA polymerase II transcription initiation surveillance
N	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
N	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
N	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
N	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
N	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
N	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle

Functional Information from PROSITE/UniProt

site_id	PS00125
Number of Residues	6
Details	SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE

Chain	Residue	Details
D	LEU114-GLU119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Repeat: {"description":"1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Repeat: {"description":"2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Repeat: {"description":"3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	26
Details	Repeat: {"description":"4; approximate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Breakpoint for translocation to form RET-CCDC6 oncogene"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	104
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	112
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	98
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	94
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P67774","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---