9O04
CryoEM structure of the FBXO42-CCDC6-PP2Ac degradasome
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| D | LEU114-GLU119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | Repeat: {"description":"3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Repeat: {"description":"4; approximate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Breakpoint for translocation to form RET-CCDC6 oncogene"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 104 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 112 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 98 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 94 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P36873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38123684","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TTB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17055435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33243860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33633399","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34762484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7K36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7PKS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P67774","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
