9NAB
Cryo-EM structure of the alpha5beta1 integrin headpiece with OS2966 Fab
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| D | TYR221-HIS227 | |
| C | TYR220-HIS226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 238 |
| Details | Domain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"23125415","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"24789099","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22451694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33962943","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3VI3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NWL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7NXD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
