9MJ5

Catalytic domain of human DNA polymerase alpha in complex with DNA and RPA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005662	cellular_component	DNA replication factor A complex
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006298	biological_process	mismatch repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0007346	biological_process	regulation of mitotic cell cycle
A	0035861	cellular_component	site of double-strand break
A	0042127	biological_process	regulation of cell population proliferation

Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSIMI

Chain	Residue	Details
S	TYR1000-ILE1008

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
S	THR406

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P33609

Chain	Residue	Details
S	LYS970
C	LYS577
A	LYS88

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068

Chain	Residue	Details
C	LYS458
C	LYS553

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