9LWC

Cryo-EM structure of epinephrine bound dopamine receptor 1 D1R-M74-miniGs-Gbeta1gamma2-Nb35 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0001588	molecular_function	dopamine neurotransmitter receptor activity, coupled via Gs
R	0001963	biological_process	synaptic transmission, dopaminergic
R	0001965	molecular_function	G-protein alpha-subunit binding
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004952	molecular_function	dopamine neurotransmitter receptor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005783	cellular_component	endoplasmic reticulum
R	0005789	cellular_component	endoplasmic reticulum membrane
R	0005886	cellular_component	plasma membrane
R	0005929	cellular_component	cilium
R	0007187	biological_process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
R	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007212	biological_process	G protein-coupled dopamine receptor signaling pathway
R	0007416	biological_process	synapse assembly
R	0007612	biological_process	learning
R	0007613	biological_process	memory
R	0007617	biological_process	mating behavior
R	0007626	biological_process	locomotory behavior
R	0007628	biological_process	adult walking behavior
R	0008306	biological_process	associative learning
R	0008542	biological_process	visual learning
R	0009410	biological_process	response to xenobiotic stimulus
R	0012505	cellular_component	endomembrane system
R	0016020	cellular_component	membrane
R	0019226	biological_process	transmission of nerve impulse
R	0021853	biological_process	cerebral cortex GABAergic interneuron migration
R	0030335	biological_process	positive regulation of cell migration
R	0030425	cellular_component	dendrite
R	0032795	molecular_function	heterotrimeric G-protein binding
R	0035240	molecular_function	dopamine binding
R	0042417	biological_process	dopamine metabolic process
R	0042734	cellular_component	presynaptic membrane
R	0043197	cellular_component	dendritic spine
R	0043268	biological_process	positive regulation of potassium ion transport
R	0043410	biological_process	positive regulation of MAPK cascade
R	0045211	cellular_component	postsynaptic membrane
R	0048167	biological_process	regulation of synaptic plasticity
R	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
R	0051584	biological_process	regulation of dopamine uptake involved in synaptic transmission
R	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
R	0060158	biological_process	phospholipase C-activating dopamine receptor signaling pathway
R	0060170	cellular_component	ciliary membrane
R	0071870	biological_process	cellular response to catecholamine stimulus
R	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
R	0097648	cellular_component	G protein-coupled receptor complex
R	0097730	cellular_component	non-motile cilium
R	0097731	cellular_component	9+0 non-motile cilium
R	0098978	cellular_component	glutamatergic synapse
R	0098982	cellular_component	GABA-ergic synapse
R	0099010	biological_process	modification of postsynaptic structure
R	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
R	1990763	molecular_function	arrestin family protein binding
R	2000986	biological_process	negative regulation of behavioral fear response

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIlNLCVISVDRYWaI

Chain	Residue	Details
R	ALA109-ILE125

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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