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9JKR

human GM-CSF with Fabs from autoantibodies, F1 and C.

Functional Information from GO Data
ChainGOidnamespacecontents
I0001821biological_processhistamine secretion
I0005125molecular_functioncytokine activity
I0005129molecular_functiongranulocyte macrophage colony-stimulating factor receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005886cellular_componentplasma membrane
I0007165biological_processsignal transduction
I0007259biological_processcell surface receptor signaling pathway via JAK-STAT
I0008284biological_processpositive regulation of cell population proliferation
I0009966biological_processregulation of signal transduction
I0010628biological_processpositive regulation of gene expression
I0010744biological_processpositive regulation of macrophage derived foam cell differentiation
I0030099biological_processmyeloid cell differentiation
I0030225biological_processmacrophage differentiation
I0030335biological_processpositive regulation of cell migration
I0030526cellular_componentgranulocyte macrophage colony-stimulating factor receptor complex
I0032747biological_processpositive regulation of interleukin-23 production
I0034021biological_processresponse to silicon dioxide
I0034405biological_processresponse to fluid shear stress
I0038157biological_processgranulocyte-macrophage colony-stimulating factor signaling pathway
I0042045biological_processepithelial fluid transport
I0043011biological_processmyeloid dendritic cell differentiation
I0045187biological_processregulation of circadian sleep/wake cycle, sleep
I0045892biological_processnegative regulation of DNA-templated transcription
I0050793biological_processregulation of developmental process
I0070665biological_processpositive regulation of leukocyte proliferation
I0071222biological_processcellular response to lipopolysaccharide
I0071803biological_processpositive regulation of podosome assembly
I0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
I0097028biological_processdendritic cell differentiation
I0097696biological_processcell surface receptor signaling pathway via STAT
I2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
DTYR198-HIS204
ATYR193-HIS199
BTYR193-HIS199
CTYR202-HIS208

site_idPS00702
Number of Residues9
DetailsGM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC
ChainResidueDetails
ICYS106-CYS114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine"}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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