9IAZ

CryoEM structure of the Themis:Grb2 complex with bound ProMacrobody 256, local refinement

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0003723	molecular_function	RNA binding
A	0005091	molecular_function	guanyl-nucleotide exchange factor adaptor activity
A	0005154	molecular_function	epidermal growth factor receptor binding
A	0005168	molecular_function	neurotrophin TRKA receptor binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0007265	biological_process	Ras protein signal transduction
A	0008180	cellular_component	COP9 signalosome
A	0008286	biological_process	insulin receptor signaling pathway
A	0017124	molecular_function	SH3 domain binding
A	0019901	molecular_function	protein kinase binding
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0030036	biological_process	actin cytoskeleton organization
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031623	biological_process	receptor internalization
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0042110	biological_process	T cell activation
A	0042267	biological_process	natural killer cell mediated cytotoxicity
A	0042770	biological_process	signal transduction in response to DNA damage
A	0042802	molecular_function	identical protein binding
A	0043408	biological_process	regulation of MAPK cascade
A	0043560	molecular_function	insulin receptor substrate binding
A	0045953	biological_process	negative regulation of natural killer cell mediated cytotoxicity
A	0046875	molecular_function	ephrin receptor binding
A	0070062	cellular_component	extracellular exosome
A	0070436	cellular_component	Grb2-EGFR complex
A	0071479	biological_process	cellular response to ionizing radiation
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008180	cellular_component	COP9 signalosome
B	0043368	biological_process	positive T cell selection
B	0043383	biological_process	negative T cell selection
B	0050852	biological_process	T cell receptor signaling pathway
C	0015768	biological_process	maltose transport
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	1901982	molecular_function	maltose binding

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
C	PRO219-ASN236

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"11726515","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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