9HVY

Cryo-EM structure of human separase-SCC1 (1-631) fusion protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000280	biological_process	nuclear division
A	0000281	biological_process	mitotic cytokinesis
A	0000775	cellular_component	chromosome, centromeric region
A	0000785	cellular_component	chromatin
A	0000794	cellular_component	condensed nuclear chromosome
A	0000922	cellular_component	spindle pole
A	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
A	0001666	biological_process	response to hypoxia
A	0003682	molecular_function	chromatin binding
A	0003824	molecular_function	catalytic activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006302	biological_process	double-strand break repair
A	0006310	biological_process	DNA recombination
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006915	biological_process	apoptotic process
A	0007131	biological_process	reciprocal meiotic recombination
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008278	cellular_component	cohesin complex
A	0010628	biological_process	positive regulation of gene expression
A	0010629	biological_process	negative regulation of gene expression
A	0010972	biological_process	negative regulation of G2/M transition of mitotic cell cycle
A	0016020	cellular_component	membrane
A	0016363	cellular_component	nuclear matrix
A	0030892	cellular_component	mitotic cohesin complex
A	0030893	cellular_component	meiotic cohesin complex
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0032720	biological_process	negative regulation of tumor necrosis factor production
A	0032733	biological_process	positive regulation of interleukin-10 production
A	0034087	biological_process	establishment of mitotic sister chromatid cohesion
A	0034088	biological_process	maintenance of mitotic sister chromatid cohesion
A	0034089	biological_process	establishment of meiotic sister chromatid cohesion
A	0034090	biological_process	maintenance of meiotic sister chromatid cohesion
A	0034351	biological_process	negative regulation of glial cell apoptotic process
A	0040001	biological_process	establishment of mitotic spindle localization
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045841	biological_process	negative regulation of mitotic metaphase/anaphase transition
A	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
A	0045875	biological_process	negative regulation of sister chromatid cohesion
A	0045876	biological_process	positive regulation of sister chromatid cohesion
A	0051306	biological_process	mitotic sister chromatid separation
A	0071168	biological_process	protein localization to chromatin
A	0072686	cellular_component	mitotic spindle
A	0098813	biological_process	nuclear chromosome segregation
A	0106222	molecular_function	lncRNA binding
A	0140297	molecular_function	DNA-binding transcription factor binding
A	1990414	biological_process	replication-born double-strand break repair via sister chromatid exchange
A	1990520	cellular_component	separase-securin complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Domain: {"description":"Peptidase C50"}

Chain

Residue

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {}

Chain

Residue

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