9HJS

Crystal structure of human geranylgeranyl diphosphate synthase mutant R235C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
A	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006720	biological_process	isoprenoid metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0030018	cellular_component	Z disc
A	0033384	biological_process	geranyl diphosphate biosynthetic process
A	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0120531	molecular_function	prenyl diphosphate synthase activity
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
B	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006720	biological_process	isoprenoid metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0030018	cellular_component	Z disc
B	0033384	biological_process	geranyl diphosphate biosynthetic process
B	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0120531	molecular_function	prenyl diphosphate synthase activity
C	0004161	molecular_function	dimethylallyltranstransferase activity
C	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
C	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006720	biological_process	isoprenoid metabolic process
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0030018	cellular_component	Z disc
C	0033384	biological_process	geranyl diphosphate biosynthetic process
C	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0045337	biological_process	farnesyl diphosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0120531	molecular_function	prenyl diphosphate synthase activity
D	0004161	molecular_function	dimethylallyltranstransferase activity
D	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
D	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006720	biological_process	isoprenoid metabolic process
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0030018	cellular_component	Z disc
D	0033384	biological_process	geranyl diphosphate biosynthetic process
D	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0045337	biological_process	farnesyl diphosphate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0120531	molecular_function	prenyl diphosphate synthase activity
E	0004161	molecular_function	dimethylallyltranstransferase activity
E	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
E	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006720	biological_process	isoprenoid metabolic process
E	0008299	biological_process	isoprenoid biosynthetic process
E	0016740	molecular_function	transferase activity
E	0030018	cellular_component	Z disc
E	0033384	biological_process	geranyl diphosphate biosynthetic process
E	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0045337	biological_process	farnesyl diphosphate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0120531	molecular_function	prenyl diphosphate synthase activity
F	0004161	molecular_function	dimethylallyltranstransferase activity
F	0004311	molecular_function	geranylgeranyl diphosphate synthase activity
F	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006720	biological_process	isoprenoid metabolic process
F	0008299	biological_process	isoprenoid biosynthetic process
F	0016740	molecular_function	transferase activity
F	0030018	cellular_component	Z disc
F	0033384	biological_process	geranyl diphosphate biosynthetic process
F	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0045337	biological_process	farnesyl diphosphate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0120531	molecular_function	prenyl diphosphate synthase activity

Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. LGlfFQIrDDYaN

Chain	Residue	Details
A	LEU180-ASN192

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site_id	PS00723
Number of Residues	15
Details	POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LLiDDie..DnsklRRG

Chain	Residue	Details
A	LEU61-GLY75

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14324","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q12051","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698791","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	30
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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