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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9GTK

KRAS in complex with DARPin 784_F5

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0001889biological_processliver development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007265biological_processRas protein signal transduction
A0007565biological_processfemale pregnancy
A0008283biological_processcell population proliferation
A0008542biological_processvisual learning
A0009629biological_processresponse to gravity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010467biological_processgene expression
A0010628biological_processpositive regulation of gene expression
A0012505cellular_componentendomembrane system
A0014009biological_processglial cell proliferation
A0016020cellular_componentmembrane
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019002molecular_functionGMP binding
A0019003molecular_functionGDP binding
A0019221biological_processcytokine-mediated signaling pathway
A0021897biological_processforebrain astrocyte development
A0030036biological_processactin cytoskeleton organization
A0030275molecular_functionLRR domain binding
A0030857biological_processnegative regulation of epithelial cell differentiation
A0032228biological_processregulation of synaptic transmission, GABAergic
A0035022biological_processpositive regulation of Rac protein signal transduction
A0035900biological_processresponse to isolation stress
A0035914biological_processskeletal muscle cell differentiation
A0043495molecular_functionprotein-membrane adaptor activity
A0043524biological_processnegative regulation of neuron apoptotic process
A0044877molecular_functionprotein-containing complex binding
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048873biological_processhomeostasis of number of cells within a tissue
A0051146biological_processstriated muscle cell differentiation
A0051384biological_processresponse to glucocorticoid
A0051385biological_processresponse to mineralocorticoid
A0051402biological_processneuron apoptotic process
A0051450biological_processmyoblast proliferation
A0060038biological_processcardiac muscle cell proliferation
A0060252biological_processpositive regulation of glial cell proliferation
A0060441biological_processepithelial tube branching involved in lung morphogenesis
A0060509biological_processtype I pneumocyte differentiation
A2000774biological_processpositive regulation of cellular senescence
C0000139cellular_componentGolgi membrane
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0001889biological_processliver development
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005741cellular_componentmitochondrial outer membrane
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0007265biological_processRas protein signal transduction
C0007565biological_processfemale pregnancy
C0008283biological_processcell population proliferation
C0008542biological_processvisual learning
C0009629biological_processresponse to gravity
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010467biological_processgene expression
C0010628biological_processpositive regulation of gene expression
C0012505cellular_componentendomembrane system
C0014009biological_processglial cell proliferation
C0016020cellular_componentmembrane
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019002molecular_functionGMP binding
C0019003molecular_functionGDP binding
C0019221biological_processcytokine-mediated signaling pathway
C0021897biological_processforebrain astrocyte development
C0030036biological_processactin cytoskeleton organization
C0030275molecular_functionLRR domain binding
C0030857biological_processnegative regulation of epithelial cell differentiation
C0032228biological_processregulation of synaptic transmission, GABAergic
C0035022biological_processpositive regulation of Rac protein signal transduction
C0035900biological_processresponse to isolation stress
C0035914biological_processskeletal muscle cell differentiation
C0043495molecular_functionprotein-membrane adaptor activity
C0043524biological_processnegative regulation of neuron apoptotic process
C0044877molecular_functionprotein-containing complex binding
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048873biological_processhomeostasis of number of cells within a tissue
C0051146biological_processstriated muscle cell differentiation
C0051384biological_processresponse to glucocorticoid
C0051385biological_processresponse to mineralocorticoid
C0051402biological_processneuron apoptotic process
C0051450biological_processmyoblast proliferation
C0060038biological_processcardiac muscle cell proliferation
C0060252biological_processpositive regulation of glial cell proliferation
C0060441biological_processepithelial tube branching involved in lung morphogenesis
C0060509biological_processtype I pneumocyte differentiation
C2000774biological_processpositive regulation of cellular senescence
D0000139cellular_componentGolgi membrane
D0000165biological_processMAPK cascade
D0000166molecular_functionnucleotide binding
D0001889biological_processliver development
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005741cellular_componentmitochondrial outer membrane
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0007265biological_processRas protein signal transduction
D0007565biological_processfemale pregnancy
D0008283biological_processcell population proliferation
D0008542biological_processvisual learning
D0009629biological_processresponse to gravity
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010467biological_processgene expression
D0010628biological_processpositive regulation of gene expression
D0012505cellular_componentendomembrane system
D0014009biological_processglial cell proliferation
D0016020cellular_componentmembrane
D0016601biological_processRac protein signal transduction
D0016787molecular_functionhydrolase activity
D0019002molecular_functionGMP binding
D0019003molecular_functionGDP binding
D0019221biological_processcytokine-mediated signaling pathway
D0021897biological_processforebrain astrocyte development
D0030036biological_processactin cytoskeleton organization
D0030275molecular_functionLRR domain binding
D0030857biological_processnegative regulation of epithelial cell differentiation
D0032228biological_processregulation of synaptic transmission, GABAergic
D0035022biological_processpositive regulation of Rac protein signal transduction
D0035900biological_processresponse to isolation stress
D0035914biological_processskeletal muscle cell differentiation
D0043495molecular_functionprotein-membrane adaptor activity
D0043524biological_processnegative regulation of neuron apoptotic process
D0044877molecular_functionprotein-containing complex binding
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048873biological_processhomeostasis of number of cells within a tissue
D0051146biological_processstriated muscle cell differentiation
D0051384biological_processresponse to glucocorticoid
D0051385biological_processresponse to mineralocorticoid
D0051402biological_processneuron apoptotic process
D0051450biological_processmyoblast proliferation
D0060038biological_processcardiac muscle cell proliferation
D0060252biological_processpositive regulation of glial cell proliferation
D0060441biological_processepithelial tube branching involved in lung morphogenesis
D0060509biological_processtype I pneumocyte differentiation
D2000774biological_processpositive regulation of cellular senescence
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsMotif: {"description":"Effector region"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues54
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsModified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsModified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30442762","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

242199

PDB entries from 2025-09-24

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