9FG9
Cryo-EM structure of the full-length alpha1beta3gamma2 GABA(A) receptor in complex with GABA and Etomidate in the long-lived symmetric desensitised state
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC |
| Chain | Residue | Details |
| B | CYS136-CYS150 | |
| C | CYS151-CYS165 | |
| A | CYS139-CYS153 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 248 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| C | GLN1-PHE236 | |
| C | ARG284-ALA295 | |
| C | LEU434-LEU436 | |
| E | LEU268-LYS279 | |
| D | ASN275-THR284 | |
| D | TYR415-GLN429 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 83 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53 |
| Chain | Residue | Details |
| C | THR237-ILE257 | |
| C | ALA264-ALA283 | |
| C | MET296-PHE320 | |
| C | TYR413-TYR433 | |
| E | ILE222-ILE242 | |
| E | SER247-HIS267 | |
| E | ALA280-ASN303 | |
| E | ILE423-TYR445 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 96 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | ASN258-PRO263 | |
| C | VAL321-SER412 | |
| E | ASN243-ALA246 | |
| E | TYR304-ALA422 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN13 | |
| C | ASN90 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53 |
| Chain | Residue | Details |
| C | ASN208 | |
| B | PHE200 | |
| E | ASP95 | |
| E | PHE200 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | TYR97 | |
| B | SER156 | |
| B | THR202 | |
| E | TYR97 | |
| E | SER156 | |
| E | THR202 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | GLU155 | |
| E | GLU155 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:30140029, ECO:0007744|PDB:6A96 |
| Chain | Residue | Details |
| B | TYR157 | |
| E | TYR157 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN8 | |
| E | ASN8 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN80 | |
| E | ASN80 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24909990, ECO:0000269|PubMed:30140029, ECO:0000269|PubMed:30602789, ECO:0000269|PubMed:35355020, ECO:0007744|PDB:6A96, ECO:0007744|PDB:6I53, ECO:0007744|PDB:7QN7 |
| Chain | Residue | Details |
| B | ASN149 | |
| E | ASN149 |
