9F42
cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1, focused on RAPTOR
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:31530866 |
| Chain | Residue | Details |
| E | SER44 | |
| E | SER122 | |
| E | SER836 | |
| E | SER982 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER696 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:31530866 |
| Chain | Residue | Details |
| E | THR706 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER719 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by RPS6KA1 => ECO:0000269|PubMed:18722121 |
| Chain | Residue | Details |
| E | SER721 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AMPK and RPS6KA1 => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:37541260, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER722 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER738 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131 |
| Chain | Residue | Details |
| E | SER791 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | SER792 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431 |
| Chain | Residue | Details |
| E | SER855 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER859 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER863 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | THR865 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER877 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715 |
| Chain | Residue | Details |
| E | LYS1097 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | THR700 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303 |
| Chain | Residue | Details |
| E | LYS932 | |
| E | LYS948 |
