Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

9F34

Cryo-EM structure of Dopamine 3 receptor:Go complex bound to bitopic FOB02-04A - Conformation B

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0006904biological_processvesicle docking involved in exocytosis
A0006936biological_processmuscle contraction
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007198biological_processadenylate cyclase-inhibiting serotonin receptor signaling pathway
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0007626biological_processlocomotory behavior
A0008016biological_processregulation of heart contraction
A0010854molecular_functionadenylate cyclase regulator activity
A0016787molecular_functionhydrolase activity
A0030425cellular_componentdendrite
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031821molecular_functionG protein-coupled serotonin receptor binding
A0031852molecular_functionmu-type opioid receptor binding
A0042734cellular_componentpresynaptic membrane
A0044297cellular_componentcell body
A0045211cellular_componentpostsynaptic membrane
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0051430molecular_functioncorticotropin-releasing hormone receptor 1 binding
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0045202cellular_componentsynapse
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0001591molecular_functiondopamine neurotransmitter receptor activity, coupled via Gi/Go
R0001963biological_processsynaptic transmission, dopaminergic
R0002031biological_processG protein-coupled receptor internalization
R0004930molecular_functionG protein-coupled receptor activity
R0004952molecular_functiondopamine neurotransmitter receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006091biological_processgeneration of precursor metabolites and energy
R0006874biological_processintracellular calcium ion homeostasis
R0007186biological_processG protein-coupled receptor signaling pathway
R0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
R0007195biological_processadenylate cyclase-inhibiting dopamine receptor signaling pathway
R0007611biological_processlearning or memory
R0007612biological_processlearning
R0007626biological_processlocomotory behavior
R0008218biological_processbioluminescence
R0008542biological_processvisual learning
R0009410biological_processresponse to xenobiotic stimulus
R0014059biological_processregulation of dopamine secretion
R0032467biological_processpositive regulation of cytokinesis
R0032922biological_processcircadian regulation of gene expression
R0034776biological_processresponse to histamine
R0035176biological_processsocial behavior
R0042220biological_processresponse to cocaine
R0042417biological_processdopamine metabolic process
R0043266biological_processregulation of potassium ion transport
R0043278biological_processresponse to morphine
R0043410biological_processpositive regulation of MAPK cascade
R0045202cellular_componentsynapse
R0045471biological_processresponse to ethanol
R0045776biological_processnegative regulation of blood pressure
R0045840biological_processpositive regulation of mitotic nuclear division
R0046717biological_processacid secretion
R0048148biological_processbehavioral response to cocaine
R0048715biological_processnegative regulation of oligodendrocyte differentiation
R0050482biological_processarachidonate secretion
R0050709biological_processnegative regulation of protein secretion
R0050883biological_processmusculoskeletal movement, spinal reflex action
R0051481biological_processnegative regulation of cytosolic calcium ion concentration
R0051584biological_processregulation of dopamine uptake involved in synaptic transmission
R0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0051967biological_processnegative regulation of synaptic transmission, glutamatergic
R0060134biological_processprepulse inhibition
R0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
R0060161biological_processpositive regulation of dopamine receptor signaling pathway
R0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwNLCAISIDRYTaV
ChainResidueDetails
RALA116-VAL132

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: (Z)-2,3-didehydrotyrosine => ECO:0000269|PubMed:8448132
ChainResidueDetails
RTYR-179
ATHR182
AASN270
AASP273
ACYS325
ALYS46
AASN47
ATHR48
ASER152
ALEU176
AARG177
ATHR178
AARG179

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: 5-imidazolinone (Ser-Gly) => ECO:0000269|PubMed:8448132
ChainResidueDetails
RTHR-180
RGLY-178

site_idSWS_FT_FI3
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RALA33-LEU55

site_idSWS_FT_FI4
Number of Residues163
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:21097933
ChainResidueDetails
RLYS56-ASN65
RASP127-ARG149
RARG210-GLN329
RASN387-CYS400

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RTYR66-TYR88

site_idSWS_FT_FI6
Number of Residues45
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:21097933
ChainResidueDetails
RLEU89-ASP104
RGLY171-ASP187
RASN352-SER366

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RVAL105-ILE126

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RVAL150-PHE170

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RPHE188-ALA209

site_idSWS_FT_FI10
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RMET330-LEU351

site_idSWS_FT_FI11
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:21097933
ChainResidueDetails
RALA367-PHE386

site_idSWS_FT_FI12
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:21097933, ECO:0007744|PDB:3PBL
ChainResidueDetails
RASP110
RPHE345
RHIS349

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN12
RASN19
RASN97
RASN173

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon