9EZC
Structure of the extracellular subdomain of a homomeric LRRC8C truncation disease mutant
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 168 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | TRP23-VAL47 | |
| B | TRP23-VAL47 | |
| C | TRP23-VAL47 | |
| D | TRP23-VAL47 | |
| E | TRP23-VAL47 | |
| F | TRP23-VAL47 | |
| G | TRP23-VAL47 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 735 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | MET48-ALA124 | |
| E | SER285-HIS314 | |
| F | MET48-ALA124 | |
| F | SER285-HIS314 | |
| G | MET48-ALA124 | |
| G | SER285-HIS314 | |
| A | SER285-HIS314 | |
| B | MET48-ALA124 | |
| B | SER285-HIS314 | |
| C | MET48-ALA124 | |
| C | SER285-HIS314 | |
| D | MET48-ALA124 | |
| D | SER285-HIS314 | |
| E | MET48-ALA124 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 133 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | LYS125-PHE144 | |
| B | LYS125-PHE144 | |
| C | LYS125-PHE144 | |
| D | LYS125-PHE144 | |
| E | LYS125-PHE144 | |
| F | LYS125-PHE144 | |
| G | LYS125-PHE144 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 819 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | TRP145-TYR262 | |
| B | TRP145-TYR262 | |
| C | TRP145-TYR262 | |
| D | TRP145-TYR262 | |
| E | TRP145-TYR262 | |
| F | TRP145-TYR262 | |
| G | TRP145-TYR262 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 147 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | VAL263-VAL284 | |
| B | VAL263-VAL284 | |
| C | VAL263-VAL284 | |
| D | VAL263-VAL284 | |
| E | VAL263-VAL284 | |
| F | VAL263-VAL284 | |
| G | VAL263-VAL284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 168 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36897307, ECO:0007744|PDB:8DXN, ECO:0007744|PDB:8DXO, ECO:0007744|PDB:8DXP, ECO:0007744|PDB:8DXQ, ECO:0007744|PDB:8DXR |
| Chain | Residue | Details |
| A | LEU315-TYR339 | |
| B | LEU315-TYR339 | |
| C | LEU315-TYR339 | |
| D | LEU315-TYR339 | |
| E | LEU315-TYR339 | |
| F | LEU315-TYR339 | |
| G | LEU315-TYR339 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER212 | |
| B | SER212 | |
| C | SER212 | |
| D | SER212 | |
| E | SER212 | |
| F | SER212 | |
| G | SER212 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q498T9 |
| Chain | Residue | Details |
| A | SER215 | |
| B | SER215 | |
| C | SER215 | |
| D | SER215 | |
| E | SER215 | |
| F | SER215 | |
| G | SER215 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN64 | |
| E | ASN70 | |
| F | ASN64 | |
| F | ASN70 | |
| G | ASN64 | |
| G | ASN70 | |
| A | ASN70 | |
| B | ASN64 | |
| B | ASN70 | |
| C | ASN64 | |
| C | ASN70 | |
| D | ASN64 | |
| D | ASN70 | |
| E | ASN64 |
