9EMZ
13C/15N-labelled Integral Membrane Enzyme LspA in the Lipid Cubic Phase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006465 | biological_process | signal peptide processing |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004175 | molecular_function | endopeptidase activity |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006465 | biological_process | signal peptide processing |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004175 | molecular_function | endopeptidase activity |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006465 | biological_process | signal peptide processing |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0004175 | molecular_function | endopeptidase activity |
| D | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006465 | biological_process | signal peptide processing |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0016020 | cellular_component | membrane |
| D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00855 |
| Number of Residues | 13 |
| Details | SPASE_II Signal peptidases II signature. VlGGALGNLYDRM |
| Chain | Residue | Details |
| A | VAL105-MET117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS |
| Chain | Residue | Details |
| A | MET1-ARG9 | |
| A | ARG90-THR96 | |
| B | MET1-ARG9 | |
| B | ARG90-THR96 | |
| C | MET1-ARG9 | |
| C | ARG90-THR96 | |
| D | MET1-ARG9 | |
| D | ARG90-THR96 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_00161, ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS |
| Chain | Residue | Details |
| A | LEU10-PHE30 | |
| B | LEU10-PHE30 | |
| C | LEU10-PHE30 | |
| D | LEU10-PHE30 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 228 |
| Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS |
| Chain | Residue | Details |
| A | GLN31-GLY67 | |
| A | LEU119-ASN140 | |
| B | GLN31-GLY67 | |
| B | LEU119-ASN140 | |
| C | GLN31-GLY67 | |
| C | LEU119-ASN140 | |
| D | GLN31-GLY67 | |
| D | LEU119-ASN140 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 168 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:26912896, ECO:0000269|PubMed:30272004, ECO:0007744|PDB:5DIR, ECO:0007744|PDB:6FMS |
| Chain | Residue | Details |
| A | TRP68-LYS89 | |
| A | TRP97-VAL118 | |
| B | TRP68-LYS89 | |
| B | TRP97-VAL118 | |
| C | TRP68-LYS89 | |
| C | TRP97-VAL118 | |
| D | TRP68-LYS89 | |
| D | TRP97-VAL118 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:26912896, ECO:0007744|PDB:5DIR |
| Chain | Residue | Details |
| A | LEU141-ALA154 | |
| B | LEU141-ALA154 | |
| C | LEU141-ALA154 | |
| D | LEU141-ALA154 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26912896, ECO:0007744|PDB:5DIR |
| Chain | Residue | Details |
| A | LEU155-GLY169 | |
| B | LEU155-GLY169 | |
| C | LEU155-GLY169 | |
| D | LEU155-GLY169 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00161, ECO:0000305|PubMed:26912896 |
| Chain | Residue | Details |
| A | ASP124 | |
| A | ASP143 | |
| B | ASP124 | |
| B | ASP143 | |
| C | ASP124 | |
| C | ASP143 | |
| D | ASP124 | |
| D | ASP143 |
