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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9DAF

L-asparaginase II (EcA2-K12)

Functional Information from PROSITE/UniProt
site_idPS00144
Number of Residues9
DetailsASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. IlATGGTIA
ChainResidueDetails
AILE6-ALA14
site_idPS00917
Number of Residues11
DetailsASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GfVitHGTDTM
ChainResidueDetails
AGLY82-MET92
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: O-isoaspartyl threonine intermediate => ECO:0000255|PROSITE-ProRule:PRU10099, ECO:0000255|PROSITE-ProRule:PRU10100, ECO:0000269|PubMed:12595697, ECO:0000269|PubMed:1906013, ECO:0000269|PubMed:8434007, ECO:0000269|PubMed:8706862
ChainResidueDetails
ATHR12
BTHR12
CTHR12
DTHR12
site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:12595697, ECO:0000269|PubMed:8434007, ECO:0007744|PDB:1NNS, ECO:0007744|PDB:3ECA
ChainResidueDetails
ASER58
ATHR89
BSER58
BTHR89
CSER58
CTHR89
DSER58
DTHR89
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 455
ChainResidueDetails
ATHR12covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
ATYR25electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor, proton relay
ATHR89electrostatic stabiliser, increase basicity, proton acceptor, proton donor, proton relay
AASP90electrostatic stabiliser, increase acidity, increase basicity, increase nucleophilicity, proton acceptor, proton donor
ALYS162proton acceptor, proton donor
AGLU283electrostatic stabiliser
site_idMCSA2
Number of Residues6
DetailsM-CSA 455
ChainResidueDetails
BTHR12covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
BTYR25electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor, proton relay
BTHR89electrostatic stabiliser, increase basicity, proton acceptor, proton donor, proton relay
BASP90electrostatic stabiliser, increase acidity, increase basicity, increase nucleophilicity, proton acceptor, proton donor
BLYS162proton acceptor, proton donor
BGLU283electrostatic stabiliser
site_idMCSA3
Number of Residues6
DetailsM-CSA 455
ChainResidueDetails
CTHR12covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
CTYR25electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor, proton relay
CTHR89electrostatic stabiliser, increase basicity, proton acceptor, proton donor, proton relay
CASP90electrostatic stabiliser, increase acidity, increase basicity, increase nucleophilicity, proton acceptor, proton donor
CLYS162proton acceptor, proton donor
CGLU283electrostatic stabiliser
site_idMCSA4
Number of Residues6
DetailsM-CSA 455
ChainResidueDetails
DTHR12covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor
DTYR25electrostatic stabiliser, increase nucleophilicity, proton acceptor, proton donor, proton relay
DTHR89electrostatic stabiliser, increase basicity, proton acceptor, proton donor, proton relay
DASP90electrostatic stabiliser, increase acidity, increase basicity, increase nucleophilicity, proton acceptor, proton donor
DLYS162proton acceptor, proton donor
DGLU283electrostatic stabiliser

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PDB entries from 2025-06-25

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