9CQ3

The gap-filling complex with Pol mu engaged in the NHEJ pathway

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000166	molecular_function	nucleotide binding
a	0000723	biological_process	telomere maintenance
a	0000725	biological_process	recombinational repair
a	0000781	cellular_component	chromosome, telomeric region
a	0000783	cellular_component	nuclear telomere cap complex
a	0000976	molecular_function	transcription cis-regulatory region binding
a	0002218	biological_process	activation of innate immune response
a	0002376	biological_process	immune system process
a	0002684	biological_process	positive regulation of immune system process
a	0003677	molecular_function	DNA binding
a	0003678	molecular_function	DNA helicase activity
a	0003684	molecular_function	damaged DNA binding
a	0003690	molecular_function	double-stranded DNA binding
a	0003691	molecular_function	double-stranded telomeric DNA binding
a	0003723	molecular_function	RNA binding
a	0003824	molecular_function	catalytic activity
a	0004386	molecular_function	helicase activity
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005667	cellular_component	transcription regulator complex
a	0005694	cellular_component	chromosome
a	0005730	cellular_component	nucleolus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
a	0006281	biological_process	DNA repair
a	0006303	biological_process	double-strand break repair via nonhomologous end joining
a	0006310	biological_process	DNA recombination
a	0006351	biological_process	DNA-templated transcription
a	0006974	biological_process	DNA damage response
a	0008094	molecular_function	ATP-dependent activity, acting on DNA
a	0010212	biological_process	response to ionizing radiation
a	0016020	cellular_component	membrane
a	0016787	molecular_function	hydrolase activity
a	0016829	molecular_function	lyase activity
a	0016853	molecular_function	isomerase activity
a	0016887	molecular_function	ATP hydrolysis activity
a	0030332	molecular_function	cyclin binding
a	0032991	cellular_component	protein-containing complex
a	0032993	cellular_component	protein-DNA complex
a	0034774	cellular_component	secretory granule lumen
a	0042162	molecular_function	telomeric DNA binding
a	0043138	molecular_function	3'-5' DNA helicase activity
a	0043564	cellular_component	Ku70:Ku80 complex
a	0044877	molecular_function	protein-containing complex binding
a	0045027	molecular_function	DNA end binding
a	0045087	biological_process	innate immune response
a	0045621	biological_process	positive regulation of lymphocyte differentiation
a	0045892	biological_process	negative regulation of DNA-templated transcription
a	0045893	biological_process	positive regulation of DNA-templated transcription
a	0045944	biological_process	positive regulation of transcription by RNA polymerase II
a	0048660	biological_process	regulation of smooth muscle cell proliferation
a	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
a	0070419	cellular_component	nonhomologous end joining complex
a	0071475	biological_process	cellular hyperosmotic salinity response
a	0071480	biological_process	cellular response to gamma radiation
a	0071481	biological_process	cellular response to X-ray
a	0097110	molecular_function	scaffold protein binding
a	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
a	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
a	1904813	cellular_component	ficolin-1-rich granule lumen
A	0000166	molecular_function	nucleotide binding
A	0000723	biological_process	telomere maintenance
A	0000725	biological_process	recombinational repair
A	0000781	cellular_component	chromosome, telomeric region
A	0000783	cellular_component	nuclear telomere cap complex
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0002684	biological_process	positive regulation of immune system process
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003691	molecular_function	double-stranded telomeric DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006351	biological_process	DNA-templated transcription
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0010212	biological_process	response to ionizing radiation
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030332	molecular_function	cyclin binding
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0034774	cellular_component	secretory granule lumen
A	0042162	molecular_function	telomeric DNA binding
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0043564	cellular_component	Ku70:Ku80 complex
A	0044877	molecular_function	protein-containing complex binding
A	0045027	molecular_function	DNA end binding
A	0045087	biological_process	innate immune response
A	0045621	biological_process	positive regulation of lymphocyte differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048660	biological_process	regulation of smooth muscle cell proliferation
A	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
A	0070419	cellular_component	nonhomologous end joining complex
A	0071475	biological_process	cellular hyperosmotic salinity response
A	0071480	biological_process	cellular response to gamma radiation
A	0071481	biological_process	cellular response to X-ray
A	0097110	molecular_function	scaffold protein binding
A	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000166	molecular_function	nucleotide binding
b	0000723	biological_process	telomere maintenance
b	0000725	biological_process	recombinational repair
b	0000781	cellular_component	chromosome, telomeric region
b	0000783	cellular_component	nuclear telomere cap complex
b	0000976	molecular_function	transcription cis-regulatory region binding
b	0002218	biological_process	activation of innate immune response
b	0002376	biological_process	immune system process
b	0003677	molecular_function	DNA binding
b	0003678	molecular_function	DNA helicase activity
b	0003684	molecular_function	damaged DNA binding
b	0003690	molecular_function	double-stranded DNA binding
b	0003691	molecular_function	double-stranded telomeric DNA binding
b	0003723	molecular_function	RNA binding
b	0004386	molecular_function	helicase activity
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
b	0006281	biological_process	DNA repair
b	0006302	biological_process	double-strand break repair
b	0006303	biological_process	double-strand break repair via nonhomologous end joining
b	0006310	biological_process	DNA recombination
b	0006351	biological_process	DNA-templated transcription
b	0006974	biological_process	DNA damage response
b	0007004	biological_process	telomere maintenance via telomerase
b	0008047	molecular_function	enzyme activator activity
b	0008094	molecular_function	ATP-dependent activity, acting on DNA
b	0016020	cellular_component	membrane
b	0016787	molecular_function	hydrolase activity
b	0016829	molecular_function	lyase activity
b	0016853	molecular_function	isomerase activity
b	0016887	molecular_function	ATP hydrolysis activity
b	0031625	molecular_function	ubiquitin protein ligase binding
b	0032040	cellular_component	small-subunit processome
b	0032204	biological_process	regulation of telomere maintenance
b	0032991	cellular_component	protein-containing complex
b	0032993	cellular_component	protein-DNA complex
b	0034462	biological_process	small-subunit processome assembly
b	0034511	molecular_function	U3 snoRNA binding
b	0034774	cellular_component	secretory granule lumen
b	0042162	molecular_function	telomeric DNA binding
b	0042254	biological_process	ribosome biogenesis
b	0043138	molecular_function	3'-5' DNA helicase activity
b	0043564	cellular_component	Ku70:Ku80 complex
b	0044877	molecular_function	protein-containing complex binding
b	0045027	molecular_function	DNA end binding
b	0045087	biological_process	innate immune response
b	0045892	biological_process	negative regulation of DNA-templated transcription
b	0048660	biological_process	regulation of smooth muscle cell proliferation
b	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
b	0070198	biological_process	protein localization to chromosome, telomeric region
b	0070419	cellular_component	nonhomologous end joining complex
b	0071480	biological_process	cellular response to gamma radiation
b	0090734	cellular_component	site of DNA damage
b	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
b	1904430	biological_process	negative regulation of t-circle formation
b	1990904	cellular_component	ribonucleoprotein complex
B	0000166	molecular_function	nucleotide binding
B	0000723	biological_process	telomere maintenance
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0000783	cellular_component	nuclear telomere cap complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0002218	biological_process	activation of innate immune response
B	0002376	biological_process	immune system process
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0003723	molecular_function	RNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
B	0006281	biological_process	DNA repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006351	biological_process	DNA-templated transcription
B	0006974	biological_process	DNA damage response
B	0007004	biological_process	telomere maintenance via telomerase
B	0008047	molecular_function	enzyme activator activity
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032040	cellular_component	small-subunit processome
B	0032204	biological_process	regulation of telomere maintenance
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0034462	biological_process	small-subunit processome assembly
B	0034511	molecular_function	U3 snoRNA binding
B	0034774	cellular_component	secretory granule lumen
B	0042162	molecular_function	telomeric DNA binding
B	0042254	biological_process	ribosome biogenesis
B	0043138	molecular_function	3'-5' DNA helicase activity
B	0043564	cellular_component	Ku70:Ku80 complex
B	0044877	molecular_function	protein-containing complex binding
B	0045027	molecular_function	DNA end binding
B	0045087	biological_process	innate immune response
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048660	biological_process	regulation of smooth muscle cell proliferation
B	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
B	0070198	biological_process	protein localization to chromosome, telomeric region
B	0070419	cellular_component	nonhomologous end joining complex
B	0071480	biological_process	cellular response to gamma radiation
B	0090734	cellular_component	site of DNA damage
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	1904430	biological_process	negative regulation of t-circle formation
B	1990904	cellular_component	ribonucleoprotein complex
c	0000723	biological_process	telomere maintenance
c	0001650	cellular_component	fibrillar center
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005694	cellular_component	chromosome
c	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
c	0006281	biological_process	DNA repair
c	0006302	biological_process	double-strand break repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006974	biological_process	DNA damage response
c	0007417	biological_process	central nervous system development
c	0010212	biological_process	response to ionizing radiation
c	0030183	biological_process	B cell differentiation
c	0030217	biological_process	T cell differentiation
c	0032807	cellular_component	DNA ligase IV complex
c	0033152	biological_process	immunoglobulin V(D)J recombination
c	0035861	cellular_component	site of double-strand break
c	0045027	molecular_function	DNA end binding
c	0051351	biological_process	positive regulation of ligase activity
c	0070182	molecular_function	DNA polymerase binding
c	0070419	cellular_component	nonhomologous end joining complex
C	0000723	biological_process	telomere maintenance
C	0001650	cellular_component	fibrillar center
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006974	biological_process	DNA damage response
C	0007417	biological_process	central nervous system development
C	0010212	biological_process	response to ionizing radiation
C	0030183	biological_process	B cell differentiation
C	0030217	biological_process	T cell differentiation
C	0032807	cellular_component	DNA ligase IV complex
C	0033152	biological_process	immunoglobulin V(D)J recombination
C	0035861	cellular_component	site of double-strand break
C	0045027	molecular_function	DNA end binding
C	0051351	biological_process	positive regulation of ligase activity
C	0070182	molecular_function	DNA polymerase binding
C	0070419	cellular_component	nonhomologous end joining complex
d	0000793	cellular_component	condensed chromosome
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
d	0006281	biological_process	DNA repair
d	0006284	biological_process	base-excision repair
d	0006302	biological_process	double-strand break repair
d	0006303	biological_process	double-strand break repair via nonhomologous end joining
d	0006310	biological_process	DNA recombination
d	0006974	biological_process	DNA damage response
d	0010165	biological_process	response to X-ray
d	0016874	molecular_function	ligase activity
d	0019899	molecular_function	enzyme binding
d	0030674	molecular_function	protein-macromolecule adaptor activity
d	0032807	cellular_component	DNA ligase IV complex
d	0033152	biological_process	immunoglobulin V(D)J recombination
d	0035861	cellular_component	site of double-strand break
d	0042802	molecular_function	identical protein binding
d	0051351	biological_process	positive regulation of ligase activity
d	0070419	cellular_component	nonhomologous end joining complex
d	0070975	molecular_function	FHA domain binding
d	1990166	biological_process	protein localization to site of double-strand break
d	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
D	0000793	cellular_component	condensed chromosome
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006302	biological_process	double-strand break repair
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006310	biological_process	DNA recombination
D	0006974	biological_process	DNA damage response
D	0010165	biological_process	response to X-ray
D	0016874	molecular_function	ligase activity
D	0019899	molecular_function	enzyme binding
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0032807	cellular_component	DNA ligase IV complex
D	0033152	biological_process	immunoglobulin V(D)J recombination
D	0035861	cellular_component	site of double-strand break
D	0042802	molecular_function	identical protein binding
D	0051351	biological_process	positive regulation of ligase activity
D	0070419	cellular_component	nonhomologous end joining complex
D	0070975	molecular_function	FHA domain binding
D	1990166	biological_process	protein localization to site of double-strand break
D	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
e	0000793	cellular_component	condensed chromosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
e	0006281	biological_process	DNA repair
e	0006284	biological_process	base-excision repair
e	0006302	biological_process	double-strand break repair
e	0006303	biological_process	double-strand break repair via nonhomologous end joining
e	0006310	biological_process	DNA recombination
e	0006974	biological_process	DNA damage response
e	0010165	biological_process	response to X-ray
e	0016874	molecular_function	ligase activity
e	0019899	molecular_function	enzyme binding
e	0030674	molecular_function	protein-macromolecule adaptor activity
e	0032807	cellular_component	DNA ligase IV complex
e	0033152	biological_process	immunoglobulin V(D)J recombination
e	0035861	cellular_component	site of double-strand break
e	0042802	molecular_function	identical protein binding
e	0051351	biological_process	positive regulation of ligase activity
e	0070419	cellular_component	nonhomologous end joining complex
e	0070975	molecular_function	FHA domain binding
e	1990166	biological_process	protein localization to site of double-strand break
e	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
E	0000793	cellular_component	condensed chromosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
E	0006281	biological_process	DNA repair
E	0006284	biological_process	base-excision repair
E	0006302	biological_process	double-strand break repair
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0006310	biological_process	DNA recombination
E	0006974	biological_process	DNA damage response
E	0010165	biological_process	response to X-ray
E	0016874	molecular_function	ligase activity
E	0019899	molecular_function	enzyme binding
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0032807	cellular_component	DNA ligase IV complex
E	0033152	biological_process	immunoglobulin V(D)J recombination
E	0035861	cellular_component	site of double-strand break
E	0042802	molecular_function	identical protein binding
E	0051351	biological_process	positive regulation of ligase activity
E	0070419	cellular_component	nonhomologous end joining complex
E	0070975	molecular_function	FHA domain binding
E	1990166	biological_process	protein localization to site of double-strand break
E	1990683	biological_process	DNA double-strand break attachment to nuclear envelope
f	0000012	biological_process	single strand break repair
f	0000166	molecular_function	nucleotide binding
f	0000287	molecular_function	magnesium ion binding
f	0000781	cellular_component	chromosome, telomeric region
f	0000793	cellular_component	condensed chromosome
f	0001701	biological_process	in utero embryonic development
f	0002328	biological_process	pro-B cell differentiation
f	0003677	molecular_function	DNA binding
f	0003909	molecular_function	DNA ligase activity
f	0003910	molecular_function	DNA ligase (ATP) activity
f	0005515	molecular_function	protein binding
f	0005524	molecular_function	ATP binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
f	0006281	biological_process	DNA repair
f	0006284	biological_process	base-excision repair
f	0006297	biological_process	nucleotide-excision repair, DNA gap filling
f	0006302	biological_process	double-strand break repair
f	0006303	biological_process	double-strand break repair via nonhomologous end joining
f	0006310	biological_process	DNA recombination
f	0006974	biological_process	DNA damage response
f	0007417	biological_process	central nervous system development
f	0008283	biological_process	cell population proliferation
f	0010165	biological_process	response to X-ray
f	0010212	biological_process	response to ionizing radiation
f	0010332	biological_process	response to gamma radiation
f	0016874	molecular_function	ligase activity
f	0032807	cellular_component	DNA ligase IV complex
f	0033077	biological_process	T cell differentiation in thymus
f	0033151	biological_process	V(D)J recombination
f	0033152	biological_process	immunoglobulin V(D)J recombination
f	0033153	biological_process	T cell receptor V(D)J recombination
f	0035019	biological_process	somatic stem cell population maintenance
f	0043524	biological_process	negative regulation of neuron apoptotic process
f	0045190	biological_process	isotype switching
f	0046872	molecular_function	metal ion binding
f	0048146	biological_process	positive regulation of fibroblast proliferation
f	0050769	biological_process	positive regulation of neurogenesis
f	0051276	biological_process	chromosome organization
f	0051301	biological_process	cell division
f	0051402	biological_process	neuron apoptotic process
f	0070419	cellular_component	nonhomologous end joining complex
f	0071479	biological_process	cellular response to ionizing radiation
f	0071897	biological_process	DNA biosynthetic process
f	0075713	biological_process	establishment of integrated proviral latency
f	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
f	2001252	biological_process	positive regulation of chromosome organization
F	0000012	biological_process	single strand break repair
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0000781	cellular_component	chromosome, telomeric region
F	0000793	cellular_component	condensed chromosome
F	0001701	biological_process	in utero embryonic development
F	0002328	biological_process	pro-B cell differentiation
F	0003677	molecular_function	DNA binding
F	0003909	molecular_function	DNA ligase activity
F	0003910	molecular_function	DNA ligase (ATP) activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
F	0006281	biological_process	DNA repair
F	0006284	biological_process	base-excision repair
F	0006297	biological_process	nucleotide-excision repair, DNA gap filling
F	0006302	biological_process	double-strand break repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006974	biological_process	DNA damage response
F	0007417	biological_process	central nervous system development
F	0008283	biological_process	cell population proliferation
F	0010165	biological_process	response to X-ray
F	0010212	biological_process	response to ionizing radiation
F	0010332	biological_process	response to gamma radiation
F	0016874	molecular_function	ligase activity
F	0032807	cellular_component	DNA ligase IV complex
F	0033077	biological_process	T cell differentiation in thymus
F	0033151	biological_process	V(D)J recombination
F	0033152	biological_process	immunoglobulin V(D)J recombination
F	0033153	biological_process	T cell receptor V(D)J recombination
F	0035019	biological_process	somatic stem cell population maintenance
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0045190	biological_process	isotype switching
F	0046872	molecular_function	metal ion binding
F	0048146	biological_process	positive regulation of fibroblast proliferation
F	0050769	biological_process	positive regulation of neurogenesis
F	0051276	biological_process	chromosome organization
F	0051301	biological_process	cell division
F	0051402	biological_process	neuron apoptotic process
F	0070419	cellular_component	nonhomologous end joining complex
F	0071479	biological_process	cellular response to ionizing radiation
F	0071897	biological_process	DNA biosynthetic process
F	0075713	biological_process	establishment of integrated proviral latency
F	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
F	2001252	biological_process	positive regulation of chromosome organization
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006974	biological_process	DNA damage response
G	0035861	cellular_component	site of double-strand break
G	0042803	molecular_function	protein homodimerization activity
G	0043564	cellular_component	Ku70:Ku80 complex
G	0060090	molecular_function	molecular adaptor activity
G	0070182	molecular_function	DNA polymerase binding
G	0070419	cellular_component	nonhomologous end joining complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0006281	biological_process	DNA repair
H	0006303	biological_process	double-strand break repair via nonhomologous end joining
H	0006974	biological_process	DNA damage response
H	0035861	cellular_component	site of double-strand break
H	0042803	molecular_function	protein homodimerization activity
H	0043564	cellular_component	Ku70:Ku80 complex
H	0060090	molecular_function	molecular adaptor activity
H	0070182	molecular_function	DNA polymerase binding
H	0070419	cellular_component	nonhomologous end joining complex
m	0003677	molecular_function	DNA binding
m	0003887	molecular_function	DNA-directed DNA polymerase activity
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0006281	biological_process	DNA repair
m	0006303	biological_process	double-strand break repair via nonhomologous end joining
m	0006310	biological_process	DNA recombination
m	0006974	biological_process	DNA damage response
m	0016740	molecular_function	transferase activity
m	0016779	molecular_function	nucleotidyltransferase activity
m	0034061	molecular_function	DNA polymerase activity
m	0046872	molecular_function	metal ion binding
m	0071897	biological_process	DNA biosynthetic process
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006281	biological_process	DNA repair
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0006310	biological_process	DNA recombination
M	0006974	biological_process	DNA damage response
M	0016740	molecular_function	transferase activity
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity
M	0046872	molecular_function	metal ion binding
M	0071897	biological_process	DNA biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00333
Number of Residues	25
Details	DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGIMVKqplsi...YKpdk...RgegwlKIK

Chain	Residue	Details
F	GLU427-LYS451

---

site_id	PS00697
Number of Residues	9
Details	DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. ETKLDGERM

Chain	Residue	Details
F	GLU271-MET279

---

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP

Chain	Residue	Details
M	GLY319-PRO338

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	414
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	218
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"10026262","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	14
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	398
Details	Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	54
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	268
Details	Region: {"description":"Globular head","evidences":[{"source":"PubMed","id":"16571728","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	84
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"18046455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Site: {"description":"Leu-lock","evidences":[{"source":"PubMed","id":"21775435","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"18644470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	136
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"14599745","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22228831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28500754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	89
Details	Domain: {"description":"BRCT 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29980672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1B","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P18858","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W1G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23523427","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3W5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	42
Details	Domain: {"description":"PISA","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"27705800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"27705800","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	9
Details	Region: {"description":"Involved in ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Site: {"description":"Responsible for the low discrimination between dNTP and rNTP"}

Chain

Residue

Details

---