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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9C5A

AP-3 Arf1 dimeric interface, focused refinement

Functional Information from GO Data
ChainGOidnamespacecontents
B0006886biological_processintracellular protein transport
B0015031biological_processprotein transport
B0016192biological_processvesicle-mediated transport
B0030117cellular_componentmembrane coat
B0030276molecular_functionclathrin binding
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0002090biological_processregulation of receptor internalization
C0003723molecular_functionRNA binding
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006878biological_processintracellular copper ion homeostasis
C0006886biological_processintracellular protein transport
C0012505cellular_componentendomembrane system
C0014069cellular_componentpostsynaptic density
C0015031biological_processprotein transport
C0016192biological_processvesicle-mediated transport
C0016787molecular_functionhydrolase activity
C0019904molecular_functionprotein domain specific binding
C0030017cellular_componentsarcomere
C0031252cellular_componentcell leading edge
C0032991cellular_componentprotein-containing complex
C0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
C0043005cellular_componentneuron projection
C0045202cellular_componentsynapse
C0060292biological_processlong-term synaptic depression
C0070062cellular_componentextracellular exosome
C0097061biological_processdendritic spine organization
C0098586biological_processcellular response to virus
C1990386biological_processmitotic cleavage furrow ingression
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005764cellular_componentlysosome
M0005765cellular_componentlysosomal membrane
M0005769cellular_componentearly endosome
M0005794cellular_componentGolgi apparatus
M0006622biological_processprotein targeting to lysosome
M0006886biological_processintracellular protein transport
M0006897biological_processendocytosis
M0008089biological_processanterograde axonal transport
M0015031biological_processprotein transport
M0016192biological_processvesicle-mediated transport
M0030123cellular_componentAP-3 adaptor complex
M0030131cellular_componentclathrin adaptor complex
M0030659cellular_componentcytoplasmic vesicle membrane
M0031267molecular_functionsmall GTPase binding
M0031410cellular_componentcytoplasmic vesicle
M0035654biological_processclathrin-coated vesicle cargo loading, AP-3-mediated
M0048490biological_processanterograde synaptic vesicle transport
M0060155biological_processplatelet dense granule organization
M0098837cellular_componentpostsynaptic recycling endosome
M0098884biological_processpostsynaptic neurotransmitter receptor internalization
M1903232biological_processmelanosome assembly
M1904115cellular_componentaxon cytoplasm
b0006886biological_processintracellular protein transport
b0015031biological_processprotein transport
b0016192biological_processvesicle-mediated transport
b0030117cellular_componentmembrane coat
b0030276molecular_functionclathrin binding
c0000139cellular_componentGolgi membrane
c0000166molecular_functionnucleotide binding
c0000287molecular_functionmagnesium ion binding
c0002090biological_processregulation of receptor internalization
c0003723molecular_functionRNA binding
c0003924molecular_functionGTPase activity
c0003925molecular_functionG protein activity
c0005515molecular_functionprotein binding
c0005525molecular_functionGTP binding
c0005737cellular_componentcytoplasm
c0005794cellular_componentGolgi apparatus
c0005829cellular_componentcytosol
c0005886cellular_componentplasma membrane
c0005925cellular_componentfocal adhesion
c0006878biological_processintracellular copper ion homeostasis
c0006886biological_processintracellular protein transport
c0012505cellular_componentendomembrane system
c0014069cellular_componentpostsynaptic density
c0015031biological_processprotein transport
c0016192biological_processvesicle-mediated transport
c0016787molecular_functionhydrolase activity
c0019904molecular_functionprotein domain specific binding
c0030017cellular_componentsarcomere
c0031252cellular_componentcell leading edge
c0032991cellular_componentprotein-containing complex
c0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
c0043005cellular_componentneuron projection
c0045202cellular_componentsynapse
c0060292biological_processlong-term synaptic depression
c0070062cellular_componentextracellular exosome
c0097061biological_processdendritic spine organization
c0098586biological_processcellular response to virus
c1990386biological_processmitotic cleavage furrow ingression
m0005515molecular_functionprotein binding
m0005737cellular_componentcytoplasm
m0005764cellular_componentlysosome
m0005765cellular_componentlysosomal membrane
m0005769cellular_componentearly endosome
m0005794cellular_componentGolgi apparatus
m0006622biological_processprotein targeting to lysosome
m0006886biological_processintracellular protein transport
m0006897biological_processendocytosis
m0008089biological_processanterograde axonal transport
m0015031biological_processprotein transport
m0016192biological_processvesicle-mediated transport
m0030123cellular_componentAP-3 adaptor complex
m0030131cellular_componentclathrin adaptor complex
m0030659cellular_componentcytoplasmic vesicle membrane
m0031267molecular_functionsmall GTPase binding
m0031410cellular_componentcytoplasmic vesicle
m0035654biological_processclathrin-coated vesicle cargo loading, AP-3-mediated
m0048490biological_processanterograde synaptic vesicle transport
m0060155biological_processplatelet dense granule organization
m0098837cellular_componentpostsynaptic recycling endosome
m0098884biological_processpostsynaptic neurotransmitter receptor internalization
m1903232biological_processmelanosome assembly
m1904115cellular_componentaxon cytoplasm
Functional Information from PROSITE/UniProt
site_idPS00990
Number of Residues21
DetailsCLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. IPWRra.GvkYtnNeAYFDVVE
ChainResidueDetails
MILE165-GLU185
site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. LsFIPPdGnFrLisY
ChainResidueDetails
MLEU248-TYR262
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues482
DetailsDomain: {"description":"MHD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00404","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues26
DetailsRegion: {"description":"Important for the stable binding to the membranes","evidences":[{"source":"UniProtKB","id":"P84080","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14690595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N-acetylglycine; alternate","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsLipidation: {"description":"N-myristoyl glycine; alternate","evidences":[{"source":"PubMed","id":"20213681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23535599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25807930","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues12
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00740","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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