9C1W

Structure of AKT2 with compound 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005938	cellular_component	cell cortex
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0006006	biological_process	glucose metabolic process
A	0006417	biological_process	regulation of translation
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007165	biological_process	signal transduction
A	0008286	biological_process	insulin receptor signaling pathway
A	0010748	biological_process	negative regulation of long-chain fatty acid import across plasma membrane
A	0010907	biological_process	positive regulation of glucose metabolic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030334	biological_process	regulation of cell migration
A	0030335	biological_process	positive regulation of cell migration
A	0032000	biological_process	positive regulation of fatty acid beta-oxidation
A	0032287	biological_process	peripheral nervous system myelin maintenance
A	0032587	cellular_component	ruffle membrane
A	0032869	biological_process	cellular response to insulin stimulus
A	0035556	biological_process	intracellular signal transduction
A	0036211	biological_process	protein modification process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
A	0045444	biological_process	fat cell differentiation
A	0045725	biological_process	positive regulation of glycogen biosynthetic process
A	0046326	biological_process	positive regulation of D-glucose import
A	0046872	molecular_function	metal ion binding
A	0050821	biological_process	protein stabilization
A	0051726	biological_process	regulation of cell cycle
A	0060644	biological_process	mammary gland epithelial cell differentiation
A	0071486	biological_process	cellular response to high light intensity
A	0072659	biological_process	protein localization to plasma membrane
A	0090314	biological_process	positive regulation of protein targeting to membrane
A	0097473	biological_process	retinal rod cell apoptotic process
A	0106310	molecular_function	protein serine kinase activity
A	0140677	molecular_function	molecular function activator activity
A	1903676	biological_process	positive regulation of cap-dependent translational initiation
A	1903898	biological_process	negative regulation of PERK-mediated unfolded protein response
A	2000147	biological_process	positive regulation of cell motility

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	34
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVrekatgryyamkilrkevIIAK

Chain	Residue	Details
A	LEU158-LYS191

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDIKleNLML

Chain	Residue	Details
A	VAL271-LEU283

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12434148","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"source":"UniProtKB","id":"P31749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---