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9BP6

Structure of alpha1B and betaI/IVb microtubule bound to GMPCPP

Replaces:  8V2I
Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003725molecular_functiondouble-stranded RNA binding
A0003924molecular_functionGTPase activity
A0005198molecular_functionstructural molecule activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005881cellular_componentcytoplasmic microtubule
A0007017biological_processmicrotubule-based process
A0015630cellular_componentmicrotubule cytoskeleton
A0016787molecular_functionhydrolase activity
A0030705biological_processcytoskeleton-dependent intracellular transport
A0031625molecular_functionubiquitin protein ligase binding
A0051301biological_processcell division
A0071353biological_processcellular response to interleukin-4
B0000226biological_processmicrotubule cytoskeleton organization
B0000278biological_processmitotic cell cycle
B0005198molecular_functionstructural molecule activity
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005641cellular_componentnuclear envelope lumen
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0007017biological_processmicrotubule-based process
B0015630cellular_componentmicrotubule cytoskeleton
B0019904molecular_functionprotein domain specific binding
B0030705biological_processcytoskeleton-dependent intracellular transport
B0031625molecular_functionubiquitin protein ligase binding
B0032794molecular_functionGTPase activating protein binding
B0032991cellular_componentprotein-containing complex
B0035578cellular_componentazurophil granule lumen
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042288molecular_functionMHC class I protein binding
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045171cellular_componentintercellular bridge
B0046872molecular_functionmetal ion binding
B0050807biological_processregulation of synapse organization
B0051225biological_processspindle assembly
B0051301biological_processcell division
B0070062cellular_componentextracellular exosome
B0071895biological_processodontoblast differentiation
B0072686cellular_componentmitotic spindle
I0000226biological_processmicrotubule cytoskeleton organization
I0000278biological_processmitotic cell cycle
I0003725molecular_functiondouble-stranded RNA binding
I0003924molecular_functionGTPase activity
I0005198molecular_functionstructural molecule activity
I0005200molecular_functionstructural constituent of cytoskeleton
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005737cellular_componentcytoplasm
I0005856cellular_componentcytoskeleton
I0005874cellular_componentmicrotubule
I0005881cellular_componentcytoplasmic microtubule
I0007017biological_processmicrotubule-based process
I0015630cellular_componentmicrotubule cytoskeleton
I0016787molecular_functionhydrolase activity
I0030705biological_processcytoskeleton-dependent intracellular transport
I0031625molecular_functionubiquitin protein ligase binding
I0051301biological_processcell division
I0071353biological_processcellular response to interleukin-4
Q0000226biological_processmicrotubule cytoskeleton organization
Q0000278biological_processmitotic cell cycle
Q0005198molecular_functionstructural molecule activity
Q0005200molecular_functionstructural constituent of cytoskeleton
Q0005515molecular_functionprotein binding
Q0005525molecular_functionGTP binding
Q0005576cellular_componentextracellular region
Q0005634cellular_componentnucleus
Q0005641cellular_componentnuclear envelope lumen
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0005856cellular_componentcytoskeleton
Q0005874cellular_componentmicrotubule
Q0007017biological_processmicrotubule-based process
Q0015630cellular_componentmicrotubule cytoskeleton
Q0019904molecular_functionprotein domain specific binding
Q0030705biological_processcytoskeleton-dependent intracellular transport
Q0031625molecular_functionubiquitin protein ligase binding
Q0032794molecular_functionGTPase activating protein binding
Q0032991cellular_componentprotein-containing complex
Q0035578cellular_componentazurophil granule lumen
Q0036464cellular_componentcytoplasmic ribonucleoprotein granule
Q0042267biological_processnatural killer cell mediated cytotoxicity
Q0042288molecular_functionMHC class I protein binding
Q0044297cellular_componentcell body
Q0044877molecular_functionprotein-containing complex binding
Q0045121cellular_componentmembrane raft
Q0045171cellular_componentintercellular bridge
Q0046872molecular_functionmetal ion binding
Q0050807biological_processregulation of synapse organization
Q0051225biological_processspindle assembly
Q0051301biological_processcell division
Q0070062cellular_componentextracellular exosome
Q0071895biological_processodontoblast differentiation
Q0072686cellular_componentmitotic spindle
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY140-GLY146
AGLY142-GLY148

site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q13509
ChainResidueDetails
BGLN11
QGLY142
QTHR143
QGLY144
QASN204
QASN226
BSER138
BGLY142
BTHR143
BGLY144
BASN204
BASN226
QGLN11
QSER138

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P68363
ChainResidueDetails
BGLU69
IGLU71
ISER140
IGLY144
ITHR145
ITHR179
IASN206
IASN228
QGLU69
ASER140
AGLY144
ATHR145
ATHR179
AASN206
AASN228
IGLN11

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P99024
ChainResidueDetails
BSER40
QSER40

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR55
BTHR285
BTHR290
QTHR55
QTHR285
QTHR290

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024
ChainResidueDetails
BLYS58
QLYS58
ISER48
ISER232

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:16371510
ChainResidueDetails
BSER172
QSER172

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.9
ChainResidueDetails
BARG318
QARG318

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:28576883
ChainResidueDetails
BGLU434
BGLU441
QGLU434
QGLU441

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:32747782
ChainResidueDetails
BGLU438
BGLU439
QGLU438
QGLU439

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: 5-glutamyl glycine => ECO:0000269|PubMed:28576883
ChainResidueDetails
BGLU442
BGLU443
QGLU442
QGLU443

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
BLYS58
QLYS58

site_idSWS_FT_FI12
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
ALYS326
BLYS324
ALYS370
QLYS324
ILYS370

223790

PDB entries from 2024-08-14

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