9AYC
Tetra-phosphorylated, E1435Q Ycf1 mutant in inward-facing wide conformation
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000329 | cellular_component | fungal-type vacuole membrane |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005773 | cellular_component | vacuole |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0008551 | molecular_function | P-type cadmium transporter activity |
| A | 0010038 | biological_process | response to metal ion |
| A | 0015127 | molecular_function | bilirubin transmembrane transporter activity |
| A | 0015431 | molecular_function | ABC-type glutathione S-conjugate transporter activity |
| A | 0015434 | molecular_function | ABC-type cadmium transporter activity |
| A | 0015723 | biological_process | bilirubin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0042144 | biological_process | vacuole fusion, non-autophagic |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0045121 | cellular_component | membrane raft |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0046686 | biological_process | response to cadmium ion |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARLSLARAV |
| Chain | Residue | Details |
| A | LEU753-VAL767 | |
| A | LEU1410-MET1424 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 159 |
| Details | TOPO_DOM: Vacuolar => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-PHE32 | |
| A | LYS95-GLU99 | |
| A | ASN152-GLY169 | |
| A | LEU300-GLY345 | |
| A | LEU444-ASN446 | |
| A | VAL552-ASN572 | |
| A | SER965-GLY1001 | |
| A | THR1088 | |
| A | GLY1202-THR1205 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ILE33-LEU53 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 981 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL54-VAL73 | |
| A | HIS121-VAL130 | |
| A | LYS191-ALA278 | |
| A | PHE367-TRP422 | |
| A | ILE468-ALA530 | |
| A | SER594-ALA943 | |
| A | TYR1024-ARG1066 | |
| A | TYR1110-LEU1180 | |
| A | VAL1227-ASN1515 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER74-SER94 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ASN100-LEU120 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ALA131-ILE151 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | PHE170-PRO190 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ILE279-VAL299 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | PHE346-TYR366 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LEU423-LEU443 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER447-ARG467 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | VAL531-PHE551 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LEU573-VAL593 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | LYS944-LEU964 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=13 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | SER1002-LYS1023 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=14 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | THR1067-ALA1087 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=15 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | THR1089-TYR1109 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=16 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | GLU1181-GLN1201 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=17 => ECO:0000255|PROSITE-ProRule:PRU00441 |
| Chain | Residue | Details |
| A | ALA1206-ILE1226 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY663 | |
| A | GLY1306 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER251 | |
| A | SER873 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SEP903 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SEP908 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950 |
| Chain | Residue | Details |
| A | TPO911 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SEP914 |
