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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9AX5

Cryo-EM structure of Phospholipase C epsilon PH-C terminus in complex with RhoA-GTP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004435molecular_functionphosphatidylinositol-4,5-bisphosphate phospholipase C activity
A0006629biological_processlipid metabolic process
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
A0035556biological_processintracellular signal transduction
C0000166molecular_functionnucleotide binding
C0000281biological_processmitotic cytokinesis
C0002363biological_processalpha-beta T cell lineage commitment
C0003189biological_processaortic valve formation
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0007264biological_processsmall GTPase-mediated signal transduction
C0007266biological_processRho protein signal transduction
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010812biological_processnegative regulation of cell-substrate adhesion
C0016477biological_processcell migration
C0016787molecular_functionhydrolase activity
C0017022molecular_functionmyosin binding
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030027cellular_componentlamellipodium
C0030036biological_processactin cytoskeleton organization
C0030054cellular_componentcell junction
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030667cellular_componentsecretory granule membrane
C0031122biological_processcytoplasmic microtubule organization
C0031982cellular_componentvesicle
C0032154cellular_componentcleavage furrow
C0032467biological_processpositive regulation of cytokinesis
C0032587cellular_componentruffle membrane
C0032956biological_processregulation of actin cytoskeleton organization
C0033688biological_processregulation of osteoblast proliferation
C0034329biological_processcell junction assembly
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035385biological_processRoundabout signaling pathway
C0036089biological_processcleavage furrow formation
C0038027biological_processapolipoprotein A-I-mediated signaling pathway
C0042476biological_processodontogenesis
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043149biological_processstress fiber assembly
C0043197cellular_componentdendritic spine
C0043296cellular_componentapical junction complex
C0043297biological_processapical junction assembly
C0043366biological_processbeta selection
C0043542biological_processendothelial cell migration
C0043931biological_processossification involved in bone maturation
C0044319biological_processwound healing, spreading of cells
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045666biological_processpositive regulation of neuron differentiation
C0045792biological_processnegative regulation of cell size
C0046638biological_processpositive regulation of alpha-beta T cell differentiation
C0050919biological_processnegative chemotaxis
C0051301biological_processcell division
C0051496biological_processpositive regulation of stress fiber assembly
C0051893biological_processregulation of focal adhesion assembly
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060193biological_processpositive regulation of lipase activity
C0061430biological_processbone trabecula morphogenesis
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0071222biological_processcellular response to lipopolysaccharide
C0071345biological_processcellular response to cytokine stimulus
C0071526biological_processsemaphorin-plexin signaling pathway
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0071944cellular_componentcell periphery
C0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
C0090307biological_processmitotic spindle assembly
C0090324biological_processnegative regulation of oxidative phosphorylation
C0097498biological_processendothelial tube lumen extension
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0101003cellular_componentficolin-1-rich granule membrane
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1902766biological_processskeletal muscle satellite cell migration
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C1903673biological_processmitotic cleavage furrow formation
C1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
C1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
C1990869biological_processcellular response to chemokine
C2000406biological_processpositive regulation of T cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues148
DetailsDomain: {"description":"PI-PLC X-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues125
DetailsDomain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues17
DetailsRegion: {"description":"Switch II region; involved in RAP1GDS1 isoform 2 binding","evidences":[{"source":"PubMed","id":"30190425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZHX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10748207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777804","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"PubMed","id":"1328215","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23871831","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-03-11

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