8ZRT

Cryo-EM structure focused on the receptor of the ET-1 bound ETBR-DNGI complex

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0005576	cellular_component	extracellular region
L	0019229	biological_process	regulation of vasoconstriction
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004962	molecular_function	endothelin receptor activity
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0008217	biological_process	regulation of blood pressure
R	0016020	cellular_component	membrane
R	0042310	biological_process	vasoconstriction
R	0048484	biological_process	enteric nervous system development

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV

Chain	Residue	Details
R	ILE187-VAL203

---

site_id	PS00270
Number of Residues	15
Details	ENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC

Chain	Residue	Details
L	CYS1-CYS15

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	49
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Peptide: {"description":"Endothelin-1","featureId":"PRO_0000008060","evidences":[{"source":"PubMed","id":"10438732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---