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8ZJE

Cryo-EM structure of kisspeptin receptor bound to TAK-448

Functional Information from GO Data
ChainGOidnamespacecontents
A0001508biological_processaction potential
A0001664molecular_functionG protein-coupled receptor binding
A0001750cellular_componentphotoreceptor outer segment
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005794cellular_componentGolgi apparatus
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0006469biological_processnegative regulation of protein kinase activity
A0007165biological_processsignal transduction
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007202biological_processobsolete activation of phospholipase C activity
A0007206biological_processphospholipase C-activating G protein-coupled glutamate receptor signaling pathway
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007218biological_processneuropeptide signaling pathway
A0007596biological_processblood coagulation
A0007603biological_processphototransduction, visible light
A0009649biological_processentrainment of circadian clock
A0010543biological_processregulation of platelet activation
A0016787molecular_functionhydrolase activity
A0030234molecular_functionenzyme regulator activity
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031965cellular_componentnuclear membrane
A0034695biological_processresponse to prostaglandin E
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0050821biological_processprotein stabilization
A0060158biological_processphospholipase C-activating dopamine receptor signaling pathway
A0060828biological_processregulation of canonical Wnt signaling pathway
A0070062cellular_componentextracellular exosome
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0045202cellular_componentsynapse
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0005929cellular_componentcilium
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007218biological_processneuropeptide signaling pathway
R0008188molecular_functionneuropeptide receptor activity
R0008528molecular_functionG protein-coupled peptide receptor activity
R0009986cellular_componentcell surface
R0016020cellular_componentmembrane
R0043231cellular_componentintracellular membrane-bounded organelle
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues106
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RMET1-PRO46
RLEU102-TYR120
RALA179-ARG202
RLEU285-LYS305

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RLEU47-ILE67

site_idSWS_FT_FI3
Number of Residues136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RCYS68-ASN78
ATHR188
AASN276
ALYS277
AASP279
ASER333
RASP139-ARG157
RTYR224-ARG263
RHIS329-LEU398
ATHR48
ASER158
ALEU182
AARG183
AARG185

site_idSWS_FT_FI4
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RPHE79-LEU101

site_idSWS_FT_FI5
Number of Residues17
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RILE121-VAL138

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RLEU158-LEU178

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RALA203-CYS223

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RLEU264-VAL284

site_idSWS_FT_FI9
Number of Residues22
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RTHR306-SER328

site_idSWS_FT_FI10
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN10
RASN18
RASN28

225946

PDB entries from 2024-10-09

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