8ZJD
Cryo-EM structure of kisspeptin receptor bound to KP-10
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU75-SER89 | |
| B | ILE162-ILE176 | |
| B | LEU290-ALA304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by MMP2 and MMP9 |
| Chain | Residue | Details |
| L | GLY217 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15144186 |
| Chain | Residue | Details |
| L | TYR211 | |
| R | ASP139-ARG157 | |
| R | TYR224-ARG263 | |
| A | ASN276 | |
| A | SER333 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phenylalanine amide => ECO:0000269|PubMed:11385580 |
| Chain | Residue | Details |
| L | PHE220 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 61 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU102-TYR120 | |
| R | ALA179-ARG202 | |
| R | LEU285-LYS305 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE121-VAL138 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU158-LEU178 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | ALA203-CYS223 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU264-VAL284 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | THR306-SER328 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN10 | |
| R | ASN18 | |
| R | ASN28 |
