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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8Z9O

Cryo-EM structure of human GPR4-Gs complex

Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ISIaFLCCISVDRYLaV
ChainResidueDetails
RILE103-VAL119
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues45
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues40
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues41
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues43
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues41
DetailsRepeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues30
DetailsRepeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues9
DetailsRegion: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues7
DetailsRegion: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues5
DetailsRegion: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues36
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues13
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues30
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues28
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues35
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues37
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues35
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues15
DetailsRegion: {"description":"Extracellular loop 2 (ECL2)","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsSite: {"description":"Required for activation","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsSite: {"description":"Proton sensing","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsSite: {"description":"Proton sensing","evidences":[{"source":"UniProtKB","id":"Q8BUD0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-07-23

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