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8YY8

Fzd7 -Gs complex

Replaces:  7EVW
Functional Information from GO Data
ChainGOidnamespacecontents
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0005109molecular_functionfrizzled binding
R0005515molecular_functionprotein binding
R0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
R0005768cellular_componentendosome
R0005886cellular_componentplasma membrane
R0006355biological_processregulation of DNA-templated transcription
R0007186biological_processG protein-coupled receptor signaling pathway
R0010008cellular_componentendosome membrane
R0010812biological_processnegative regulation of cell-substrate adhesion
R0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
R0016020cellular_componentmembrane
R0016055biological_processWnt signaling pathway
R0017147molecular_functionWnt-protein binding
R0019827biological_processstem cell population maintenance
R0030165molecular_functionPDZ domain binding
R0030182biological_processneuron differentiation
R0033077biological_processT cell differentiation in thymus
R0034446biological_processsubstrate adhesion-dependent cell spreading
R0035567biological_processnon-canonical Wnt signaling pathway
R0042327biological_processpositive regulation of phosphorylation
R0042666biological_processnegative regulation of ectodermal cell fate specification
R0042813molecular_functionWnt receptor activity
R0043231cellular_componentintracellular membrane-bounded organelle
R0043410biological_processpositive regulation of MAPK cascade
R0045893biological_processpositive regulation of DNA-templated transcription
R0046330biological_processpositive regulation of JNK cascade
R0048103biological_processsomatic stem cell division
R0055038cellular_componentrecycling endosome membrane
R0060054biological_processpositive regulation of epithelial cell proliferation involved in wound healing
R0060070biological_processcanonical Wnt signaling pathway
R0060071biological_processWnt signaling pathway, planar cell polarity pathway
R0060231biological_processmesenchymal to epithelial transition
R0060828biological_processregulation of canonical Wnt signaling pathway
R0071300biological_processcellular response to retinoic acid
R2000726biological_processnegative regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04896
ChainResidueDetails
AGLY47
ASER54
ALYS338
APHE345
ATHR364

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250
ChainResidueDetails
AARG342
RSER358-GLN379
RVAL445-ARG470
RSER550-VAL574

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231
ChainResidueDetails
RILE289-LEU309

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
ChainResidueDetails
RGLU310-CYS336
RGLN401-GLY423
RGLU492-THR528

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RTHR337-LEU357

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RTYR380-GLY400

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RPHE424-PHE444

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RILE471-TYR491

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RVAL529-TRP549

site_idSWS_FT_FI10
Number of Residues1
DetailsSITE: Essential for SDCBP-mediated plasma membrane phosphatidylinositol-4,5-bisphosphate recognition => ECO:0000269|PubMed:27386966
ChainResidueDetails
RLYS569

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN63
RASN164

222926

PDB entries from 2024-07-24

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