8YX1

CD40 in complex with Bleselumab Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0009897	cellular_component	external side of plasma membrane
C	0038023	molecular_function	signaling receptor activity
C	0042113	biological_process	B cell activation
C	0050776	biological_process	regulation of immune response
R	0009897	cellular_component	external side of plasma membrane
R	0038023	molecular_function	signaling receptor activity
R	0042113	biological_process	B cell activation
R	0050776	biological_process	regulation of immune response

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR200-HIS206

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site_id	PS00652
Number of Residues	34
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Crekq..Ylinsq.....C..Csl.Cqpgqklvsd..Cteft..ETEC

Chain	Residue	Details
R	CYS6-CYS39

---

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtCeeGWhctsea..C

Chain	Residue	Details
R	CYS83-CYS96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	84
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	80
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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