8YQ0

Crystal structure of human phosphoribosyl pyrophosphate synthetase 1(PRPS1) chimera swapped with three residues from PRPS2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004749	molecular_function	ribose phosphate diphosphokinase activity
A	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004749	molecular_function	ribose phosphate diphosphokinase activity
B	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004749	molecular_function	ribose phosphate diphosphokinase activity
C	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004749	molecular_function	ribose phosphate diphosphokinase activity
D	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004749	molecular_function	ribose phosphate diphosphokinase activity
E	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
E	0009165	biological_process	nucleotide biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004749	molecular_function	ribose phosphate diphosphokinase activity
F	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
F	0009165	biological_process	nucleotide biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0004749	molecular_function	ribose phosphate diphosphokinase activity
G	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
G	0009165	biological_process	nucleotide biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0004749	molecular_function	ribose phosphate diphosphokinase activity
H	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
H	0009165	biological_process	nucleotide biosynthetic process
I	0000287	molecular_function	magnesium ion binding
I	0004749	molecular_function	ribose phosphate diphosphokinase activity
I	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
I	0009165	biological_process	nucleotide biosynthetic process
J	0000287	molecular_function	magnesium ion binding
J	0004749	molecular_function	ribose phosphate diphosphokinase activity
J	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
J	0009165	biological_process	nucleotide biosynthetic process
K	0000287	molecular_function	magnesium ion binding
K	0004749	molecular_function	ribose phosphate diphosphokinase activity
K	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
K	0009165	biological_process	nucleotide biosynthetic process
L	0000287	molecular_function	magnesium ion binding
L	0004749	molecular_function	ribose phosphate diphosphokinase activity
L	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
L	0009165	biological_process	nucleotide biosynthetic process
M	0000287	molecular_function	magnesium ion binding
M	0004749	molecular_function	ribose phosphate diphosphokinase activity
M	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
M	0009165	biological_process	nucleotide biosynthetic process
N	0000287	molecular_function	magnesium ion binding
N	0004749	molecular_function	ribose phosphate diphosphokinase activity
N	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
N	0009165	biological_process	nucleotide biosynthetic process
O	0000287	molecular_function	magnesium ion binding
O	0004749	molecular_function	ribose phosphate diphosphokinase activity
O	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
O	0009165	biological_process	nucleotide biosynthetic process
P	0000287	molecular_function	magnesium ion binding
P	0004749	molecular_function	ribose phosphate diphosphokinase activity
P	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
P	0009165	biological_process	nucleotide biosynthetic process
Q	0000287	molecular_function	magnesium ion binding
Q	0004749	molecular_function	ribose phosphate diphosphokinase activity
Q	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
Q	0009165	biological_process	nucleotide biosynthetic process
R	0000287	molecular_function	magnesium ion binding
R	0004749	molecular_function	ribose phosphate diphosphokinase activity
R	0009156	biological_process	ribonucleoside monophosphate biosynthetic process
R	0009165	biological_process	nucleotide biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00114
Number of Residues	16
Details	PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD

Chain	Residue	Details
A	ASP131-ASP146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	270
Details	Region: {"description":"Binding of phosphoribosylpyrophosphate","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	90
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---