8YPY
Crystal strcuture of human phosphoribosyl pyrophosphate synthetase2 (PRPS2) in complex with ligands
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| A | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| B | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| C | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| C | 0009165 | biological_process | nucleotide biosynthetic process |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| D | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| D | 0009165 | biological_process | nucleotide biosynthetic process |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| E | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| E | 0009165 | biological_process | nucleotide biosynthetic process |
| F | 0000287 | molecular_function | magnesium ion binding |
| F | 0004749 | molecular_function | ribose phosphate diphosphokinase activity |
| F | 0009156 | biological_process | ribonucleoside monophosphate biosynthetic process |
| F | 0009165 | biological_process | nucleotide biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00114 |
| Number of Residues | 16 |
| Details | PRPP_SYNTHASE Phosphoribosyl pyrophosphate synthase signature. DLHAsQIQGFFdiPVD |
| Chain | Residue | Details |
| A | ASP131-ASP146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 75 |
| Details | Region: {"description":"Binding of phosphoribosylpyrophosphate","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 47 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40295500","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8YPY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 69 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37248548","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7YK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2024","submissionDatabase":"PDB data bank","title":"Structure of human PRPS2 long isoform at 3.4 Angstroms resolution.","authors":["Liu J.L.","Lu G.M."]}},{"source":"PDB","id":"8YI9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40295500","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2024","submissionDatabase":"PDB data bank","title":"Structure of human PRPS2 long isoform at 3.4 Angstroms resolution.","authors":["Liu J.L.","Lu G.M."]}},{"source":"PDB","id":"8YI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YPY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
