8YAT

SOD1, Nanobody1, Nanobody2 and Nanobody3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000303	biological_process	response to superoxide
A	0001541	biological_process	ovarian follicle development
A	0001819	biological_process	positive regulation of cytokine production
A	0001890	biological_process	placenta development
A	0001895	biological_process	retina homeostasis
A	0001975	biological_process	response to amphetamine
A	0002262	biological_process	myeloid cell homeostasis
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005764	cellular_component	lysosome
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006749	biological_process	glutathione metabolic process
A	0006801	biological_process	superoxide metabolic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0007566	biological_process	embryo implantation
A	0007605	biological_process	sensory perception of sound
A	0007626	biological_process	locomotory behavior
A	0008089	biological_process	anterograde axonal transport
A	0008090	biological_process	retrograde axonal transport
A	0008217	biological_process	regulation of blood pressure
A	0008270	molecular_function	zinc ion binding
A	0009408	biological_process	response to heat
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019226	biological_process	transmission of nerve impulse
A	0019430	biological_process	removal of superoxide radicals
A	0019899	molecular_function	enzyme binding
A	0030141	cellular_component	secretory granule
A	0030346	molecular_function	protein phosphatase 2B binding
A	0031045	cellular_component	dense core granule
A	0031267	molecular_function	small GTPase binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031667	biological_process	response to nutrient levels
A	0032287	biological_process	peripheral nervous system myelin maintenance
A	0032839	cellular_component	dendrite cytoplasm
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032991	cellular_component	protein-containing complex
A	0033081	biological_process	regulation of T cell differentiation in thymus
A	0034465	biological_process	response to carbon monoxide
A	0034599	biological_process	cellular response to oxidative stress
A	0035865	biological_process	cellular response to potassium ion
A	0040014	biological_process	regulation of multicellular organism growth
A	0042542	biological_process	response to hydrogen peroxide
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043087	biological_process	regulation of GTPase activity
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045471	biological_process	response to ethanol
A	0046620	biological_process	regulation of organ growth
A	0046688	biological_process	response to copper ion
A	0046716	biological_process	muscle cell cellular homeostasis
A	0046872	molecular_function	metal ion binding
A	0048538	biological_process	thymus development
A	0048678	biological_process	response to axon injury
A	0050665	biological_process	hydrogen peroxide biosynthetic process
A	0050728	biological_process	negative regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0051087	molecular_function	protein-folding chaperone binding
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0060047	biological_process	heart contraction
A	0060052	biological_process	neurofilament cytoskeleton organization
A	0060087	biological_process	relaxation of vascular associated smooth muscle
A	0060088	biological_process	auditory receptor cell stereocilium organization
A	0070062	cellular_component	extracellular exosome
A	0071276	biological_process	cellular response to cadmium ion
A	0071318	biological_process	cellular response to ATP
A	0072593	biological_process	reactive oxygen species metabolic process
A	0097332	biological_process	response to antipsychotic drug
A	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1904115	cellular_component	axon cytoplasm
E	0000303	biological_process	response to superoxide
E	0001541	biological_process	ovarian follicle development
E	0001819	biological_process	positive regulation of cytokine production
E	0001890	biological_process	placenta development
E	0001895	biological_process	retina homeostasis
E	0001975	biological_process	response to amphetamine
E	0002262	biological_process	myeloid cell homeostasis
E	0004784	molecular_function	superoxide dismutase activity
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0005764	cellular_component	lysosome
E	0005777	cellular_component	peroxisome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006749	biological_process	glutathione metabolic process
E	0006801	biological_process	superoxide metabolic process
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0007566	biological_process	embryo implantation
E	0007605	biological_process	sensory perception of sound
E	0007626	biological_process	locomotory behavior
E	0008089	biological_process	anterograde axonal transport
E	0008090	biological_process	retrograde axonal transport
E	0008217	biological_process	regulation of blood pressure
E	0008270	molecular_function	zinc ion binding
E	0009408	biological_process	response to heat
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019226	biological_process	transmission of nerve impulse
E	0019430	biological_process	removal of superoxide radicals
E	0019899	molecular_function	enzyme binding
E	0030141	cellular_component	secretory granule
E	0030346	molecular_function	protein phosphatase 2B binding
E	0031045	cellular_component	dense core granule
E	0031267	molecular_function	small GTPase binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031667	biological_process	response to nutrient levels
E	0032287	biological_process	peripheral nervous system myelin maintenance
E	0032839	cellular_component	dendrite cytoplasm
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032991	cellular_component	protein-containing complex
E	0033081	biological_process	regulation of T cell differentiation in thymus
E	0034465	biological_process	response to carbon monoxide
E	0034599	biological_process	cellular response to oxidative stress
E	0035865	biological_process	cellular response to potassium ion
E	0040014	biological_process	regulation of multicellular organism growth
E	0042542	biological_process	response to hydrogen peroxide
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043025	cellular_component	neuronal cell body
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043087	biological_process	regulation of GTPase activity
E	0043410	biological_process	positive regulation of MAPK cascade
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0045471	biological_process	response to ethanol
E	0046620	biological_process	regulation of organ growth
E	0046688	biological_process	response to copper ion
E	0046716	biological_process	muscle cell cellular homeostasis
E	0046872	molecular_function	metal ion binding
E	0048538	biological_process	thymus development
E	0048678	biological_process	response to axon injury
E	0050665	biological_process	hydrogen peroxide biosynthetic process
E	0050728	biological_process	negative regulation of inflammatory response
E	0050766	biological_process	positive regulation of phagocytosis
E	0051087	molecular_function	protein-folding chaperone binding
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0060047	biological_process	heart contraction
E	0060052	biological_process	neurofilament cytoskeleton organization
E	0060087	biological_process	relaxation of vascular associated smooth muscle
E	0060088	biological_process	auditory receptor cell stereocilium organization
E	0070062	cellular_component	extracellular exosome
E	0071276	biological_process	cellular response to cadmium ion
E	0071318	biological_process	cellular response to ATP
E	0072593	biological_process	reactive oxygen species metabolic process
E	0097332	biological_process	response to antipsychotic drug
E	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1904115	cellular_component	axon cytoplasm
I	0000303	biological_process	response to superoxide
I	0001541	biological_process	ovarian follicle development
I	0001819	biological_process	positive regulation of cytokine production
I	0001890	biological_process	placenta development
I	0001895	biological_process	retina homeostasis
I	0001975	biological_process	response to amphetamine
I	0002262	biological_process	myeloid cell homeostasis
I	0004784	molecular_function	superoxide dismutase activity
I	0005507	molecular_function	copper ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005759	cellular_component	mitochondrial matrix
I	0005764	cellular_component	lysosome
I	0005777	cellular_component	peroxisome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006749	biological_process	glutathione metabolic process
I	0006801	biological_process	superoxide metabolic process
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0007566	biological_process	embryo implantation
I	0007605	biological_process	sensory perception of sound
I	0007626	biological_process	locomotory behavior
I	0008089	biological_process	anterograde axonal transport
I	0008090	biological_process	retrograde axonal transport
I	0008217	biological_process	regulation of blood pressure
I	0008270	molecular_function	zinc ion binding
I	0009408	biological_process	response to heat
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019226	biological_process	transmission of nerve impulse
I	0019430	biological_process	removal of superoxide radicals
I	0019899	molecular_function	enzyme binding
I	0030141	cellular_component	secretory granule
I	0030346	molecular_function	protein phosphatase 2B binding
I	0031045	cellular_component	dense core granule
I	0031267	molecular_function	small GTPase binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0031667	biological_process	response to nutrient levels
I	0032287	biological_process	peripheral nervous system myelin maintenance
I	0032839	cellular_component	dendrite cytoplasm
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0032991	cellular_component	protein-containing complex
I	0033081	biological_process	regulation of T cell differentiation in thymus
I	0034465	biological_process	response to carbon monoxide
I	0034599	biological_process	cellular response to oxidative stress
I	0035865	biological_process	cellular response to potassium ion
I	0040014	biological_process	regulation of multicellular organism growth
I	0042542	biological_process	response to hydrogen peroxide
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043025	cellular_component	neuronal cell body
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043087	biological_process	regulation of GTPase activity
I	0043410	biological_process	positive regulation of MAPK cascade
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0045471	biological_process	response to ethanol
I	0046620	biological_process	regulation of organ growth
I	0046688	biological_process	response to copper ion
I	0046716	biological_process	muscle cell cellular homeostasis
I	0046872	molecular_function	metal ion binding
I	0048538	biological_process	thymus development
I	0048678	biological_process	response to axon injury
I	0050665	biological_process	hydrogen peroxide biosynthetic process
I	0050728	biological_process	negative regulation of inflammatory response
I	0050766	biological_process	positive regulation of phagocytosis
I	0051087	molecular_function	protein-folding chaperone binding
I	0051881	biological_process	regulation of mitochondrial membrane potential
I	0060047	biological_process	heart contraction
I	0060052	biological_process	neurofilament cytoskeleton organization
I	0060087	biological_process	relaxation of vascular associated smooth muscle
I	0060088	biological_process	auditory receptor cell stereocilium organization
I	0070062	cellular_component	extracellular exosome
I	0071276	biological_process	cellular response to cadmium ion
I	0071318	biological_process	cellular response to ATP
I	0072593	biological_process	reactive oxygen species metabolic process
I	0097332	biological_process	response to antipsychotic drug
I	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I	1904115	cellular_component	axon cytoplasm
M	0000303	biological_process	response to superoxide
M	0001541	biological_process	ovarian follicle development
M	0001819	biological_process	positive regulation of cytokine production
M	0001890	biological_process	placenta development
M	0001895	biological_process	retina homeostasis
M	0001975	biological_process	response to amphetamine
M	0002262	biological_process	myeloid cell homeostasis
M	0004784	molecular_function	superoxide dismutase activity
M	0005507	molecular_function	copper ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0005764	cellular_component	lysosome
M	0005777	cellular_component	peroxisome
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0006749	biological_process	glutathione metabolic process
M	0006801	biological_process	superoxide metabolic process
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006979	biological_process	response to oxidative stress
M	0007283	biological_process	spermatogenesis
M	0007566	biological_process	embryo implantation
M	0007605	biological_process	sensory perception of sound
M	0007626	biological_process	locomotory behavior
M	0008089	biological_process	anterograde axonal transport
M	0008090	biological_process	retrograde axonal transport
M	0008217	biological_process	regulation of blood pressure
M	0008270	molecular_function	zinc ion binding
M	0009408	biological_process	response to heat
M	0016209	molecular_function	antioxidant activity
M	0016491	molecular_function	oxidoreductase activity
M	0019226	biological_process	transmission of nerve impulse
M	0019430	biological_process	removal of superoxide radicals
M	0019899	molecular_function	enzyme binding
M	0030141	cellular_component	secretory granule
M	0030346	molecular_function	protein phosphatase 2B binding
M	0031045	cellular_component	dense core granule
M	0031267	molecular_function	small GTPase binding
M	0031410	cellular_component	cytoplasmic vesicle
M	0031667	biological_process	response to nutrient levels
M	0032287	biological_process	peripheral nervous system myelin maintenance
M	0032839	cellular_component	dendrite cytoplasm
M	0032930	biological_process	positive regulation of superoxide anion generation
M	0032991	cellular_component	protein-containing complex
M	0033081	biological_process	regulation of T cell differentiation in thymus
M	0034465	biological_process	response to carbon monoxide
M	0034599	biological_process	cellular response to oxidative stress
M	0035865	biological_process	cellular response to potassium ion
M	0040014	biological_process	regulation of multicellular organism growth
M	0042542	biological_process	response to hydrogen peroxide
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0043025	cellular_component	neuronal cell body
M	0043065	biological_process	positive regulation of apoptotic process
M	0043066	biological_process	negative regulation of apoptotic process
M	0043087	biological_process	regulation of GTPase activity
M	0043410	biological_process	positive regulation of MAPK cascade
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0045471	biological_process	response to ethanol
M	0046620	biological_process	regulation of organ growth
M	0046688	biological_process	response to copper ion
M	0046716	biological_process	muscle cell cellular homeostasis
M	0046872	molecular_function	metal ion binding
M	0048538	biological_process	thymus development
M	0048678	biological_process	response to axon injury
M	0050665	biological_process	hydrogen peroxide biosynthetic process
M	0050728	biological_process	negative regulation of inflammatory response
M	0050766	biological_process	positive regulation of phagocytosis
M	0051087	molecular_function	protein-folding chaperone binding
M	0051881	biological_process	regulation of mitochondrial membrane potential
M	0060047	biological_process	heart contraction
M	0060052	biological_process	neurofilament cytoskeleton organization
M	0060087	biological_process	relaxation of vascular associated smooth muscle
M	0060088	biological_process	auditory receptor cell stereocilium organization
M	0070062	cellular_component	extracellular exosome
M	0071276	biological_process	cellular response to cadmium ion
M	0071318	biological_process	cellular response to ATP
M	0072593	biological_process	reactive oxygen species metabolic process
M	0097332	biological_process	response to antipsychotic drug
M	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
M	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
A	GLY44-THR54

---

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
A	GLY138-ILE149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Cross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---